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BioTech, Volume 11, Issue 4

2022 December - 13 articles

Cover Story: The interaction of SARS-CoV-2 with ACE2 receptors on host cells is a biological process, based on a chemical reaction similar to protein–ligand interactions. The thermodynamic driving force for this reaction is Gibbs energy of binding. RNA viruses exhibit a great tendency to mutate. SARS-CoV-2 has mutated several dozen times, as new variants appeared. Mutations lead to changes in genetic material, its information content, empirical formula, as well as enthalpy, entropy and Gibbs energy of binding and biosynthesis. The variant with a more negative Gibbs energy of binding will have a greater entry rate into host cells and thus an advantage, leading to the suppression of earlier variants. Gibbs energy of binding of BA.2.75 is more negative than those of BA.2 and BA.5. Thus, it is expected to dominate in a new pandemic wave. View this paper
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Articles (13)

  • Article
  • Open Access
15 Citations
4,934 Views
15 Pages

Plasma versus Serum Analysis by FTIR Spectroscopy to Capture the Human Physiological State

  • Rúben Araújo,
  • Luís Ramalhete,
  • Edna Ribeiro and
  • Cecília Calado

9 December 2022

Fourier Transform InfraRed spectroscopy of serum and plasma has been highly explored for medical diagnosis, due to its general simplicity, and high sensitivity and specificity. To evaluate the plasma and serum molecular fingerprint, as obtained by FT...

  • Article
  • Open Access
8 Citations
4,146 Views
15 Pages

Enzymatic Oxidation of Ferulic Acid as a Way of Preparing New Derivatives

  • Abdulhadi Aljawish,
  • Isabelle Chevalot,
  • Cédric Paris and
  • Lionel Muniglia

5 December 2022

The ferulic acid (FA)-oxidation by Myceliophthora thermophila laccase was performed in phosphate buffer at 30 °C and pH 7.5 as an eco-friendly procedure. LC-MS analysis showed that oxidation products were four dehydrodimers (P1, P2, P3, P5) at MM...

  • Article
  • Open Access
8 Citations
5,732 Views
16 Pages

Identification of Potential Antimalarial Drug Candidates Targeting Falcipain-2 Protein of Malaria Parasite—A Computational Strategy

  • Shrikant Nema,
  • Kanika Verma,
  • Ashutosh Mani,
  • Neha Shree Maurya,
  • Archana Tiwari and
  • Praveen Kumar Bharti

30 November 2022

Falcipain-2 (FP-2) is one of the main haemoglobinase of P. falciparum which is an important molecular target for the treatment of malaria. In this study, we have screened alkaloids to identify potential inhibitors against FP-2 since alkaloids possess...

  • Review
  • Open Access
6 Citations
4,766 Views
18 Pages

21 November 2022

Members of the phylum Actinomycetota (formerly Actinobacteria) have historically been the most prolific providers of small bioactive molecules. Although the genus Streptomyces is the best-known member for this issue, other genera, such as Gordonia, h...

  • Article
  • Open Access
3,345 Views
10 Pages

10 November 2022

Beet yellows virus, which belongs to the genus Closterovirus, family Closteroviridae and has a significant negative economic impact, has proven to be challenging to detect and diagnose. To obtain antibodies against BYV, we propose an easier bioinform...

  • Communication
  • Open Access
2 Citations
3,996 Views
10 Pages

29 October 2022

Biofilters are biological air-phase packed-bed reactors used for the removal of industrial air pollutants such as volatile organic compounds (VOCs) and odors. Because of the economic and environmental benefits, biofilter technology is preferred in ap...

  • Article
  • Open Access
3 Citations
3,375 Views
14 Pages

Gut Microbiome Remains Static in Functional Abdominal Pain Disorders Patients Compared to Controls: Potential for Diagnostic Tools

  • Bassam Abomoelak,
  • Miguel Saps,
  • Sailendharan Sudakaran,
  • Chirajyoti Deb and
  • Devendra Mehta

27 October 2022

Background: Functional Abdominal Pain disorders (FAPDs) are a group of heterogeneous gastrointestinal disorders with unclear pathophysiology. In children, FAPDs are more common in the winter months than summer months. The possible influence of school...

  • Article
  • Open Access
1 Citations
3,588 Views
18 Pages

Plug-and-Display Photo-Switchable Systems on Plant Virus Nanoparticles

  • Louisa Kauth,
  • Eva Miriam Buhl,
  • Julian Luka,
  • Karolin Richter,
  • Ulrich Commandeur and
  • Christina Dickmeis

21 October 2022

Light can be used to regulate protein interactions with a high degree of spatial and temporal precision. Photo-switchable systems therefore allow the development of controllable protein complexes that can influence various cellular and molecular proc...

  • Review
  • Open Access
35 Citations
11,933 Views
22 Pages

Biotechnological Interventions in Tomato (Solanum lycopersicum) for Drought Stress Tolerance: Achievements and Future Prospects

  • Ram Krishna,
  • Waquar Akhter Ansari,
  • P. S. Soumia,
  • Akhilesh Yadav,
  • Durgesh Kumar Jaiswal,
  • Sudhir Kumar,
  • Achuit Kumar Singh,
  • Major Singh and
  • Jay Prakash Verma

19 October 2022

Tomato production is severely affected by abiotic stresses (drought, flood, heat, and salt) and causes approximately 70% loss in yield depending on severity and duration of the stress. Drought is the most destructive abiotic stress and tomato is very...

  • Editorial
  • Open Access
2 Citations
2,704 Views
3 Pages

15 October 2022

The COVID-19 disease (Coronavirus Disease 19), caused by the SARS-CoV-2 virus (Severe Acute Respiratory Syndrome Coronavirus 2), has posed many challenges worldwide at various levels, with special focus to the biological, medical, and epidemiological...

  • Feature Paper
  • Article
  • Open Access
10 Citations
3,645 Views
13 Pages

12 October 2022

Microflora is actively used to produce value-added materials in industry, and each cell density should be controlled for stable microflora use. In this study, a simple system evaluating the cell density was constructed with artificial intelligence (A...

  • Article
  • Open Access
19 Citations
4,352 Views
11 Pages

11 October 2022

Omicron BA.2.75 may become the next globally dominant strain of COVID-19 in 2022. The BA.2.75 sub-variant has acquired more mutations (9) in spike protein and other genes of SARS-CoV-2 than any other variant. Thus, its chemical composition and thermo...

  • Review
  • Open Access
86 Citations
16,697 Views
21 Pages

30 September 2022

The microbial fuel cell has been considered a promising alternative to traditional fossil energy. It has great potential in energy production, waste management, and biomass valorization. However, it has several technical issues, such as low power gen...

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BioTech - ISSN 2673-6284