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BioChem, Volume 2, Issue 4

2022 December - 5 articles

Cover Story: Skin has been widely used for toxicity and safety evaluation during the process of drug research and development, formerly performed in vivo using a variety of animal species. Nowadays, with increased ethical issues related to animal experimentation, the development of non-animal models is essential to avoid animal suffering. This work shows the development of a canine skin analog, the cEpiderm, a histotypical cell culture-derived tissue suitable for animal free testing, following the OECD guidelines, imperative to avoid harmful, drawn-out tests to assess chemicals for their capacity to disrupt skin or cause sensitization. This is a promising canine epidermis model for the development and evaluation of new drugs for topical application. View this paper

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Articles (5)

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Article

10 Citations

3,669 Views

11 Pages

Synergistic Antibacterial Activity of Green Gold Nanoparticles and Tannin-Based Derivatives

Elisângela Gomes De Lima Oliveira,
Simone Araújo Vieira,
Fernando Antônio Gomes Da Silva,
Mateus Matiuzzi Da Costa,
Anderson S. L. Gomes and
Helinando P. De Oliveira

BioChem2022, 2(4), 269-279;https://doi.org/10.3390/biochem2040019

15 December 2022

The development of composites with antibacterial activity represents an important strategy to avoid side effects such as increasing bacterial resistance to antibiotics. In particular, the green synthesis of metal nanoparticles avoids the use of hazar...

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Article

5 Citations

6,898 Views

9 Pages

Oil Spill in Brazil—Analysis of Vulnerabilities and Socio-Environmental Conflicts

Mariana Olívia Santana dos Santos,
Mariana Maciel Nepomuceno,
José Erivaldo Gonçalves,
Ana Catarina Leite Véras Medeiros,
Rafaella Miranda Machado,
Caroline Pontes da Silva Santos,
Maria José Cremilda Ferreira Alves,
Aline do Monte Gurgel and
Idê Gomes Dantas Gurgel

BioChem2022, 2(4), 260-268;https://doi.org/10.3390/biochem2040018

9 December 2022

The 2019 oil spill was considered the largest environmental disaster in the Brazilian Northeastern coast. It was associated with mostly ineffective government actions, thus intensifying historical vulnerabilities faced by local populations. We aimed...

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Review

8 Citations

6,374 Views

19 Pages

The Role of Epitranscriptomic Modifications in the Regulation of RNA–Protein Interactions

Elzbieta Wanowska,
Alexis McFeely and
Joanna Sztuba-Solinska

BioChem2022, 2(4), 241-259;https://doi.org/10.3390/biochem2040017

25 November 2022

Epitranscriptome refers to post-transcriptional modifications to RNA and their associated regulatory factors that can govern changes in an organism’s cells in response to various environmental stimuli. Recent studies have recognized over 170 di...

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Communication

2 Citations

2,923 Views

20 Pages

Bilayers as Basic Formation of Epimolecular Structure of Mostly Lyotropic (Hydrotropic) Structuralized Liquid Systems Being Influenced Predominantly by the Temperature

Miloslav Milichovský

BioChem2022, 2(4), 221-240;https://doi.org/10.3390/biochem2040016

10 November 2022

The bilayer’s formations of amphiphilic molecules or polyions of different ionogenity comprise the basic building units of most organic biological and non-biological systems. A theory has evolved to explain their behaviour during the creation o...

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Article

1 Citations

3,968 Views

6 Pages

cEpiderm, a Canine Skin Analog Suitable for In Vivo Testing Replacement

Mariana Marques,
João Nunes,
Bárbara Ustymenko,
Luísa Fialho,
Luís Martins,
Anthony J. Burke,
Cesar Filho,
Alexandre C. Craveiro,
Ana R. Costa and
Célia M. Antunes
+ 1 author

BioChem2022, 2(4), 215-220;https://doi.org/10.3390/biochem2040015

20 October 2022

Skin is one of the organs most tested for toxicity and safety evaluation during the process of drug research and development and in the past has usually been performed in vivo using animals. Over the last few years, non-animal alternatives have been...

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