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BioChem, Volume 5, Issue 1

2025 March - 4 articles

Cover Story: Cancers are still a leading cause of death worldwide. A newly identified subclass of flavonoids, dimeric flavonoids, have sparked scientific interest due to their anticancer activity. Several studies have characterized the potential anticancer activity of dimeric flavonoids as compounds that disrupt the hallmark features, causing cell cycle arrest, inducing apoptosis, inhibiting angiogenesis, suppressing invasion, leading to anti-inflammatory/immunoregulatory effects, and inhibiting the effects of proinflammatory enzymes. The general findings in this review highlight the great potential of applying dimeric compounds in cancer therapy, due to their availability in nature, possible laboratory restructuring, and interaction with chemotherapeutic drugs either by reducing toxicity levels or amplifying their action and combating their associated resistance. View this paper

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Article

2 Citations

2,033 Views

25 Pages

Overproduction of Phenolic Compounds in Pseudomonas putida KT2440 Through Endogen Deregulation of the Shikimate Pathway

William Merre,
Ricardo Andrade,
Cyril Perot,
Alexia Chandor-Proust and
Caroline Ranquet

BioChem2025, 5(1), 4;https://doi.org/10.3390/biochem5010004

11 March 2025

Metabolic engineering of the shikimate pathway offers a promising strategy for enhancing the production of aromatic compounds in microbial hosts. However, feedback inhibition of key enzymes, such as the 3-deoxy-D-arabino-heptulosonate 7-phosphate syn...

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Review

3,109 Views

21 Pages

Therapeutic Management of Ebola Virus: Targeting Oxidative Stress and Inflammatory Pathways

Martin Ndayambaje,
Hicham Wahnou,
Abdallah Naya and
Mounia Oudghiri

BioChem2025, 5(1), 3;https://doi.org/10.3390/biochem5010003

11 February 2025

The Ebola virus (EBOV), a highly lethal pathogen causing hemorrhagic fever, poses a persistent public health threat, with devastating multi-organ complications and high transmission potential through bodily fluids. EBOV’s pathogenesis is marked...

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Review

2 Citations

1,987 Views

18 Pages

An Overview of the Therapeutic Potential of Dimeric Flavonoids for Targeting Cancer Hallmarks

Inês Lopes,
Isabel Meireles,
Rafaela Rocha,
Rui Medeiros and
Fátima Cerqueira

BioChem2025, 5(1), 2;https://doi.org/10.3390/biochem5010002

14 January 2025

Evidence found in the literature indicates that dimeric flavonoids constitute important therapeutic options against cancer. Using these molecules to prevent cancer progression might be a novel and promising therapeutic approach with advantages like f...

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Article

2 Citations

3,557 Views

17 Pages

Synthesis and Investigation of Tricyclic Isoquinoline Derivatives as Antibacterial Agents

Matthew J. A. Phillips,
Alison T. Ung,
Elizabeth J. Harry,
Jason Ashmore and
Andrew M. McDonagh

BioChem2025, 5(1), 1;https://doi.org/10.3390/biochem5010001

31 December 2024

Isoquinoline derivatives exhibit a range of biological properties, including antibacterial activity, and are thus attractive as a scaffold for developing broad-spectrum antibacterial compounds. A series of six isoquinoline-based compounds were synthe...

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