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COVID, Volume 3, Issue 4

2023 April - 16 articles

Cover Story: The use of molecular models has been combined, for the first time, with experimental in vitro studies in order to discover that one of the most prescribed drugs round the Earth, aspirin, might also become a new efficient treatment for bunyavirus infections. As a safe, easily administrable, and inexpensive drug, our discovery illustrates the substantial potential applications of repurposing to fight against viruses beyond SARS-CoV-2. View this paper
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Articles (16)

  • Article
  • Open Access
1 Citations
3,618 Views
12 Pages

A Mediation Model of Self-Efficacy and Depression between Burnout and Alcohol Consumption among Health Workers during the COVID-19 Pandemic

  • Alejandra del Carmen Domínguez-Espinosa,
  • Fátima Laborda Sánchez,
  • Alma Mireya Polo Velázquez and
  • Graciela Polanco Hernández

20 April 2023

To verify the role played by burnout in the prediction of alcohol consumption, considering the integration of the theory of job demands-resources (JD-R) and sociocognitive theory (SCT), we developed an analytical model in which self-efficacy and depr...

  • Brief Report
  • Open Access
1,845 Views
6 Pages

19 April 2023

In developing in vitro diagnostic (IVD) tests, in particular at-home/over-the-counter (OTC) tests, one of the generally accepted exclusion criteria in IVD clinical trial protocols has been that of subjects with prior knowledge of their positive statu...

  • Article
  • Open Access
3 Citations
3,815 Views
15 Pages

17 April 2023

In the course of SARS-CoV-2 infection, the 3CL or nsp5 protease plays a pivotal role as the most important viral protease required for the maturation of viral proteins during host infection. Herein, we simulated for 500 ns 3CLproWT, 3CLproH41A, 3CLpr...

  • Article
  • Open Access
5 Citations
2,553 Views
21 Pages

15 April 2023

Prior to the emergence of the Omicron variant, we found large regional differences (ƞ2 = 0.19) in the frequency of wearing face masks in New Zealand even though the strength of people’s motivation to wear face masks to prevent the spread o...

  • Communication
  • Open Access
2 Citations
5,478 Views
9 Pages

13 April 2023

Monitored infection and vaccination rates during past past waves of the coronavirus are used to infer a posteriori two-key parameter of the SIRV epidemic model, namely, the real-time variation in (i) the ratio of recovery to infection rate and (ii) t...

  • Article
  • Open Access
1 Citations
3,996 Views
25 Pages

Macrophage-Induced Exacerbation of Nasopharyngeal Inflammatory Lymphocytes in COVID-19 Disease

  • Mohamad Ammar Ayass,
  • Trivendra Tripathi,
  • Natalya Griko,
  • Ramya Ramankutty Nair,
  • Jin Zhang,
  • Kevin Zhu,
  • Wanying Cao,
  • Victor Pashkov,
  • Tutku Okyay and
  • Lina Abi-Mosleh
  • + 1 author

13 April 2023

The nasal microenvironment plays a crucial role in the transmission, modulation, and clinical progression of COVID-19; however, the immune responses at the site of viral entry remain poorly understood. We deciphered the link between nasopharyngeal (N...

  • Article
  • Open Access
3 Citations
3,104 Views
12 Pages

10 April 2023

Objective: To compare the performance of established scoring systems (CURB65, NEWS2, qSOFA, SOFA and REDS) to the newly developed scores (ISARIC 4C, PRIEST and novel COVID-19 severity scores) in mortality prediction for patients with confirmed COVID-...

  • Article
  • Open Access
4 Citations
3,737 Views
12 Pages

7 April 2023

Recent global changes, including increased health risks and economic instability associated with the coronavirus (COVID-19) pandemic, highlight the need for mental health researchers to regularly and frequently monitor sociodemographic shifts. To min...

  • Article
  • Open Access
3 Citations
4,538 Views
23 Pages

High-Affinity Neutralizing DNA Aptamers against SARS-CoV-2 Spike Protein Variants

  • Mohamad Ammar Ayass,
  • Natalya Griko,
  • Victor Pashkov,
  • Trivendra Tripathi,
  • Wanying Cao,
  • Nazanin Javan,
  • Jun Dai,
  • Jin Zhang,
  • Kevin Zhu and
  • Lina Abi-Mosleh

7 April 2023

The continuous emergence of new variants of concern for SARS-CoV-2 has created a challenge for existing therapies. To address this, we developed a series of single-stranded DNA aptamers that not only bind specifically to the trimer S protein of SARS-...

  • Review
  • Open Access
3 Citations
7,752 Views
26 Pages

Revisiting the COVID-19 Pandemic: An Insight into Long-Term Post-COVID Complications and Repurposing of Drugs

  • Rajib Majumder,
  • Sanmitra Ghosh,
  • Manoj K. Singh,
  • Arpita Das,
  • Swagata Roy Chowdhury,
  • Abinit Saha and
  • Rudra P. Saha

6 April 2023

SARS-CoV-2 is a highly contagious and dangerous coronavirus that has been spreading around the world since late December 2019. Severe COVID-19 has been observed to induce severe damage to the alveoli, and the slow loss of lung function led to the dea...

  • Article
  • Open Access
4 Citations
3,366 Views
14 Pages

6 April 2023

This study sought to examine the impact of long-COVID symptoms on the occupational status of teachers after recovery. A mixed-methods study was conducted in Israel in June 2022 among teachers who had recovered within the past six months. The quantita...

  • Communication
  • Open Access
2 Citations
3,546 Views
8 Pages

Genetic Diversity and Spatiotemporal Distribution of SARS-CoV-2 Alpha Variant in India

  • Jahnavi Parasar,
  • Rudra Kumar Pandey,
  • Yashvant Patel,
  • Prajjval Pratap Singh,
  • Anshika Srivastava,
  • Rahul Kumar Mishra,
  • Bhupendra Kumar,
  • Niraj Rai,
  • Vijaya Nath Mishra and
  • Gyaneshwer Chaubey
  • + 5 authors

31 March 2023

After the spill to humans, in the evolutionary timeline of SARS-CoV-2, several positively selected variants have emerged. A phylogeographic study on these variants can reveal their spatial and temporal distribution. In December 2020, the alpha varian...

  • Article
  • Open Access
3 Citations
8,714 Views
20 Pages

Comparative Analysis and Classification of SARS-CoV-2 Spike Protein Structures in PDB

  • Memoona Aslam,
  • M. Saqib Nawaz,
  • Philippe Fournier-Viger and
  • Wenjin Li

29 March 2023

The Spike (S) protein of the SARS-CoV-2 virus that causes the COVID-19 disease is considered the most important target for vaccine, drug and therapeutic research as it attaches and binds to the ACE2 receptor of the host cells and allows the entry of...

  • Article
  • Open Access
1 Citations
2,820 Views
12 Pages

Microbial Organisms in the Lower Respiratory Tract Associated with SARS-CoV-2 Infection: A Cross-Sectional Study in Northern Ghana

  • Oliver Nangkuu Deberu,
  • Godfred Acheampong,
  • Bernard Nkrumah,
  • Nana Kwame Ayisi-Boateng,
  • Stephen Opoku Afriyie,
  • Francis Opoku Agyapong,
  • Dorcas Ohui Owusu,
  • Mohamed Mutocheluh,
  • Abass Abdul-Karim and
  • Michael Owusu
  • + 2 authors

29 March 2023

Colonization of SARS-CoV-2 with specific bacteria may either protect or increase the risk of disease severity. This study aimed to identify microbial organisms in the lower respiratory tract and their association with SARS-CoV-2 infection. This was a...

  • Article
  • Open Access
3,014 Views
12 Pages

SARS-CoV-2 Contacts’ Symptom Development and Secondary Attack Rate: A Retrospective Analysis of a Contact-Tracing Cohort in Catalonia

  • Meritxell Mallafré-Larrosa,
  • Mercè Herrero Garcia,
  • Sergi Mendoza-Funes,
  • Èrica Martínez-Solanas,
  • Glòria Patsi-Bosch,
  • Jacobo Mendioroz Peña and
  • Pilar Ciruela Navas

24 March 2023

Contact tracing outcome indicators, such as symptom development (SD) and secondary attack rate (SAR) among close contacts (CCs), are key to understanding SARS-CoV-2 transmission. This study analyses SD and SAR and estimates the incubation period (IP)...

  • Article
  • Open Access
3,225 Views
10 Pages

Low CD4 Counts and History of Sore Throat Predict High SARS-CoV-2 Seropositivity among Human Immunodeficiency Virus-Infected Patients in Mwanza, Tanzania

  • Helmut A. Nyawale,
  • Mariam M. Mirambo,
  • Fabian Chacha,
  • Nyambura Moremi,
  • Mohamed Mohamed,
  • Phares C. Lutema,
  • Betrand Msemwa,
  • James Samwel Mundamshimu,
  • Bartholomeo Nicholaus and
  • Stephen E. Mshana

24 March 2023

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic. Despite the fact that it affects all ages and profiles, some evidence shows that patients with comor...

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COVID - ISSN 2673-8112