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Biologics, Volume 5, Issue 3

2025 September - 12 articles

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Articles (12)

  • Review
  • Open Access
3,809 Views
26 Pages

Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review

  • Daniela J. Romero,
  • George Hussey and
  • Héctor Capella-Monsonís

5 September 2025

Extracellular matrix (ECM) bioscaffolds have demonstrated therapeutic potential across a variety of clinical and preclinical applications for tissue repair and regeneration. In parallel, these scaffolds and their components have shown the capacity to...

  • Review
  • Open Access
2 Citations
3,609 Views
34 Pages

Advancing Early Detection of Osteoarthritis Through Biomarker Profiling and Predictive Modelling: A Review

  • Laura Jane Coleman,
  • John L. Byrne,
  • Stuart Edwards and
  • Rosemary O’Hara

4 September 2025

Osteoarthritis (OA) is a multifactorial chronic musculoskeletal disorder characterised by cartilage degradation, synovial inflammation, and subchondral bone remodelling. Conventional diagnostic modalities, including radiographic imaging and symptom-b...

  • Brief Report
  • Open Access
1,222 Views
7 Pages

Cypress Pollen-Peach Cross-Reactivity: The Emerging Role of Pru p 7 as a Marker of Severe Allergic Phenotypes

  • Mara De Amici,
  • Claudio Tirelli,
  • Fiorella Barocci,
  • Alessia Marseglia,
  • Giorgia Testa,
  • Gian L. Marseglia and
  • Amelia Licari

3 September 2025

Background: The peach allergen Pru p 7, a member of the Gibberellin-Regulated Protein (GRP) family, has emerged as a key marker of severe fruit-induced allergies. It is hypothesized to mediate cross-reactivity between fruit allergens and cypress poll...

  • Article
  • Open Access
2,136 Views
10 Pages

Background/Objectives: The relative efficacy of 8 mg aflibercept compared to 2 mg in treating neovascular age-related macular degeneration (nAMD) has not been fully established. This study aims to compare the visual and anatomical outcomes of afliber...

  • Article
  • Open Access
1,335 Views
15 Pages

Background/Objectives: Fasting-induced elevation of blood ketone body levels suppresses allergic reactions; however, the underlying mechanism remains unclear. This study investigated whether elevated ketone body levels affect allergic contact dermati...

  • Case Report
  • Open Access
1,892 Views
10 Pages

Fibrotic Chronic Eosinophilic Pneumonia Treated with an Anti-IL-5 Monoclonal Antibody: A Case Report

  • Umberto Semenzato,
  • Daniele Previtero,
  • Gioele Castelli,
  • Eleonora Ruzzini,
  • Elisabetta Cocconcelli,
  • Mariaenrica Tinè,
  • Roberto Padoan,
  • Elisabetta Balestro,
  • Simonetta Baraldo and
  • Paolo Spagnolo

Background: Chronic eosinophilic pneumonia (CEP) is a rare inflammatory lung disease typically responsive to glucocorticoids, but is prone to relapse and, in some cases, progressive deterioration. A subset of patients develops fibrosing CEP, a distin...

  • Article
  • Open Access
1,253 Views
13 Pages

Background and Objectives: The cytokine IL-6, methyltransferase NSD2, pro-protein convertase Furin, and growth factor receptor IGF-1R are essential factors in the proliferation of cancer cells. These proteins are involved in the tumor process by gene...

  • Review
  • Open Access
2,827 Views
23 Pages

Immunological Strategies for Enhancing Viral Neutralization and Protection in Antibody-Guided Vaccine Design

  • Dimitrina Miteva,
  • Maria Kokudeva,
  • Latchesar Tomov,
  • Hristiana Batselova and
  • Tsvetelina Velikova

Background: Immunological strategies for antibody-guided vaccine design intend to enhance viral neutralization and protection and increase efficacy. Here, we discuss advances in antibody-guided vaccine design and current antibody-guided strategies, i...

  • Article
  • Open Access
1,304 Views
10 Pages

Impact of Antidiabetic Medication on Therapy Outcomes in Metastatic Urothelial Cancer Patients Receiving Enfortumab Vedotin Monotherapy

  • Laila Schneidewind,
  • Bernhard Kiss,
  • Friedemann Zengerling,
  • Annemarie Uhlig,
  • Niklas Klümper,
  • Thomas Büttner,
  • Julia Heinzelbecker,
  • Thomas Elegeert,
  • Cem Aksoy and
  • Jennifer Kranz
  • + 7 authors

Objectives: The aim of this study was to assess the association of diabetes mellitus and its medications with overall response (ORR) and mortality or cancer-specific survival (CSS) in patients with metastatic urothelial cancer receiving enfortumab ve...

  • Article
  • Open Access
1,643 Views
21 Pages

Antiproliferative Potential of Eugenia uniflora L. Leaf Essential Oil in Normal and Tumoral Human Colon Cells

  • Ana G. Sánchez,
  • Macarena Menoni,
  • Pamela Lombardo,
  • Eduardo Dellacassa,
  • María Angélica Severi,
  • Gabriela Ferragut,
  • Beatriz Vignale,
  • Juan Cedano,
  • María José Zuluaga and
  • Deborah J. Keszenman

Background/Objectives: Natural products are important in healthcare due to their accessibility and linkage to a healthy lifestyle. However, their effectiveness is uncertain due to insufficient scientific data. Cancer patients are frequent users of na...

  • Article
  • Open Access
2,002 Views
18 Pages

Unraveling Potential Compounds of Uncaria gambir (W.Hunter) Roxb. as Antikeloid Agent: In Silico, In Vitro and Ex Vivo Experimental Validation

  • Sri Suciati Ningsih,
  • Sri Widia A. Jusman,
  • Rahimi Syaidah,
  • Muhamad Arif Budiman,
  • Alfi Khatib and
  • Fadilah Fadilah

Background/Objectives: Keloid treatment remains challenging due to limited effectiveness and patient dissatisfaction. Herbal-based therapy offers promising alternatives that require further investigation. Uncaria gambir (W.Hunter) Roxb., an original...

  • Article
  • Open Access
3 Citations
1,348 Views
20 Pages

Background/Objectives: Research efforts and substantial funding have been dedicated to finding cost-effective and sustainable alternatives to antibiotics. Probiotics have been proposed as promising substitutes for antibiotics in human nutrition and l...

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Biologics - ISSN 2673-8449