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International Journal of Translational Medicine, Volume 1, Issue 2

2021 September - 4 articles

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Articles (4)

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Article

6 Citations

5,414 Views

18 Pages

Interleukin-6 Trans-Signaling Mediated Regulation of Paracellular Permeability in Human Retinal Endothelial Cells

Joshua Glass,
Rebekah Robinson,
Tae-Jin Lee,
Ashok Sharma and
Shruti Sharma

Int. J. Transl. Med.2021, 1(2), 137-153;https://doi.org/10.3390/ijtm1020010

16 September 2021

Long-term hyperglycemia-mediated oxidative stress and inflammation lead to the blood-retinal barrier (BRB) dysfunction and increased vascular permeability associated with diabetic retinopathy (DR). Interleukin-6 (IL-6) is one of the primary mediators...

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Article

5 Citations

4,614 Views

22 Pages

Crosstalk of Endothelial and Mesenchymal Stromal Cells under Tissue-Related O₂

Olga Zhidkova,
Elena Andreeva,
Mariia Ezdakova and
Ludmila Buravkova

Int. J. Transl. Med.2021, 1(2), 116-136;https://doi.org/10.3390/ijtm1020009

7 September 2021

Mesenchymal stromal cells (MSCs) are considered a valuable tool for cell therapy. After systemic administration, the outcome of MSCs and endothelial cells (ECs) interactions strongly depend on the local microenvironment and tissue O₂ levels in partic...

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Article

4 Citations

4,746 Views

15 Pages

Heparin–Avastin Complexes Show Enhanced VEGF Binding and Inhibition of VEGF-Mediated Cell Migration

Divyabharathy Tsiros,
Casey E. Sheehy and
Matthew A. Nugent

Int. J. Transl. Med.2021, 1(2), 101-115;https://doi.org/10.3390/ijtm1020008

10 August 2021

Bevacizumab (known by the tradename Avastin) is an antibody that binds VEGF and blocks its binding to VEGF receptors on endothelial cells, and is used to treat cancers and other diseases associated with excessive vascular growth. Our previous finding...

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Article

4,386 Views

18 Pages

Regional Differences in Gene Expression of Proliferating Human Choroidal Endothelial Cells

Andrew C. Browning,
Eugene P. Halligan,
Elizabeth A. Stewart,
Daniel C. Swan,
Simon J. Cockell and
Winfried M. Amoaku

Int. J. Transl. Med.2021, 1(2), 83-100;https://doi.org/10.3390/ijtm1020007

1 July 2021

Choroidal diseases including inflammation and neovascularization seem to have predilection for different vascular beds. In order to improve our understanding of human macular choroidal angiogenic diseases, we investigate the differences in gene expre...

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