Abstract
Stroke is a serious health problem all over the world and the second most common cause of death and permanent disability in people, after heart attacks. Oxidative stress plays an important role in the pathogenesis of acute ischemic stroke (AIS). The aim of our study was to evaluate the temporal profile of the melatonin metabolite 6-hydroxymelatonin sulphate (6-SM) in the urine and carbonyl groups in the serum of patients with acute ischemic stroke treated with intravenous thrombolysis. There were statistically significant differences between the values of 6-SM and carbonyls compared to the control group. Statistical differences were also found in the concentrations of the examined parameters depending on the type of stroke. The correlations between the concentrations of 6-SM and the carbonyl groups measured in various time intervals and between the concentration of biomarkers and mortality was also evaluated. The results indicate increased oxidative stress and the intense increase in the concentration of carbonyl groups in patients with AIS, which could be potential markers of protein damage in thrombolytic patients. Melatonin supplementation in AIS patients can also be considered, as it can effectively prevent both behavioral and neurophysiological defects caused by cerebral hypoxia and ischemia.
Supplementary Materials
The following are available online at https://www.mdpi.com/article/10.3390/ECMC2022-13156/s1.
Author Contributions
Conceptualization, H.P.; methodology, H.P., M.K., R.K. and M.P.; validation, H.P., R.K.; investigation, H.P., M.K., M.P., M.G.; resources, H.P., E.G. and G.K.; writing—original draft preparation, H.P. and R.K.; writing—review and editing, H.P., R.K., A.K., G.G., A.W. and G.K.; visualization, H.P. and M.P.; supervision, H.P.; project administration, H.P.; funding acquisition, H.P., A.W. and R.K.; All authors have read and agreed to the published version of the manuscript.
Funding
This work has been supported by Nicolaus Copernicus University as part of the Initiative of excellence competition—Research University—“Debuts” (10/2022) and Research Project, Collegium Medicum in 2022.
Institutional Review Board Statement
The study was conducted in accordance with the Declaration of Helsinki, and approved by the local Ethics Committee (No KB 637/2016).
Informed Consent Statement
Informed consent was obtained from all subjects involved in the study.
Data Availability Statement
Data available from the authors.
Conflicts of Interest
The authors declare no conflict of interest.
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