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SynBio, Volume 2, Issue 4 (December 2024) – 1 article

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15 pages, 8243 KiB  
Review
Solid-Binding Peptide for Enhancing Biocompatibility of Metallic Biomaterials
by Satoshi Migita
SynBio 2024, 2(4), 329-343; https://doi.org/10.3390/synbio2040020 - 25 Sep 2024
Viewed by 213
Abstract
Solid-binding peptides (SBPs) are a powerful tool for surface modification of metallic biomaterials which improve the biocompatibility and functionality of medical devices. This review provides a comprehensive overview of SBP technology for metallic biomaterials. We begin with a focus on phage display technology, [...] Read more.
Solid-binding peptides (SBPs) are a powerful tool for surface modification of metallic biomaterials which improve the biocompatibility and functionality of medical devices. This review provides a comprehensive overview of SBP technology for metallic biomaterials. We begin with a focus on phage display technology, the cornerstone method for selecting and developing SBPs. The application of SBPs to major metallic biomaterials, including titanium, stainless steel, and cobalt–chromium alloys, is then extensively discussed with specific examples and outcomes. We also address the advantages of SBPs compared to traditional surface modification methods, such as their high specificity and biocompatibility. Furthermore, this review explores current challenges in the field, such as the integration of computational approaches for rational SBP design. To create multifunctional surfaces, the combination of SBPs with other advanced technologies is also considered. This review aims to provide a thorough understanding of the current state and future potential of SBP technology in enhancing metallic biomaterials for medical application. Full article
(This article belongs to the Special Issue Feature Paper Collection in Synthetic Biology)
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