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Article

Effects of Sodium–Glucose Cotransporter 2 Inhibitors in Diabetic and Non-Diabetic Patients with Advanced Chronic Kidney Disease in Peritoneal Dialysis on Residual Kidney Function: In Real-World Data

by
Esperanza Moral Berrio
1,
José C. De La Flor
2,3,*,
Minerva Arambarri Segura
1,
Pablo Rodríguez-Doyágüez
4,
Alberto Martínez Calero
1,
Rocío Zamora
5,
Michael Cieza-Terrones
6,
Claudia Yuste-Lozano
7,
María Dolores Sánchez de la Nieta García
1,
Javier Nieto Iglesias
1 and
Carmen Vozmediano Poyatos
1
1
Department of Nephrology, Hospital General Universitario de Ciudad Real, 13005 Ciudad Real, Spain
2
Department of Nephrology, Hospital Central de la Defensa Gómez Ulla, 28047 Madrid, Spain
3
Department of Medicine and Medical Specialties, Faculty of Medicine, Alcala University, 28805 Madrid, Spain
4
Department of Nephrology, Guadalajara Center Dialysis, AVERICUM, 19003 Guadalajara, Spain
5
Department of Nephrology, Hospital Universitario General Villalba, 28400 Madrid, Spain
6
Faculty of Medicine, Peruana Cayetano Heredia University, Lima 15002, Peru
7
Department of Nephrology, Hospital 12 de Octubre, 28041 Madrid, Spain
*
Author to whom correspondence should be addressed.
Medicina 2024, 60(8), 1198; https://doi.org/10.3390/medicina60081198
Submission received: 1 July 2024 / Revised: 20 July 2024 / Accepted: 22 July 2024 / Published: 24 July 2024
(This article belongs to the Section Urology & Nephrology)
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Abstract

Background and Objectives: Peritoneal dialysis (PD) is a renal replacement therapy modality in which the dialysis dose can be individually adapted according to the patients’ residual kidney function (RKF). RKF is a crucial factor for technique and patient survival. Pharmacological strategies aimed at slowing the loss of RKF in patients on PD are limited. Therefore, we aimed to assess the potential effects and safety of sodium–glucose cotransporter 2 (SGLT-2) inhibitors on the preservation of RKF in patients with and without type 2 diabetes mellitus (T2DM) on PD during an average follow-up of 6 months. Materials and Methods: In this retrospective observational, single-center study on real-world data, we included patients from the Peritoneal Dialysis Unit of the Hospital General Universitario de Ciudad Real, who started treatment with SGLT-2 inhibitors during the period from December 2022 to December 2023. Data on analytical and clinical parameters, RKF, and peritoneal membrane transport function were retrospectively collected at months 0, 3, and 6. Results: Out of 31 patients in our unit, 16 prevalent patients initiated treatment with SGLT-2 inhibitors (13 empagliflozin and 3 dapagliflozin). A total of 62.5% were male and the mean age was 67.3 years. The baseline peritoneal ultrafiltration was higher in the non-diabetic patient (NDMP) group than in the diabetic patient (DMP) group. However, the residual diuresis volume, 24 h residual renal clearance rate of urea in urine, and 24 h proteinuria were higher in the DMP group than in the NDMP group. At the sixth month, patients in both groups preserved RKF and diuresis, with a trend towards a non-significant reduction in proteinuria and blood pressure. Only two patients of the DMP group presented adverse effects. Conclusions: The use of SGLT-2 inhibitors in our sample of patients with and without T2DM on PD appears to be safe and effective to preserve RKF.
Keywords: sodium–glucose cotransporter 2 inhibitors; peritoneal dialysis; residual kidney function sodium–glucose cotransporter 2 inhibitors; peritoneal dialysis; residual kidney function

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MDPI and ACS Style

Moral Berrio, E.; De La Flor, J.C.; Arambarri Segura, M.; Rodríguez-Doyágüez, P.; Martínez Calero, A.; Zamora, R.; Cieza-Terrones, M.; Yuste-Lozano, C.; Sánchez de la Nieta García, M.D.; Nieto Iglesias, J.; et al. Effects of Sodium–Glucose Cotransporter 2 Inhibitors in Diabetic and Non-Diabetic Patients with Advanced Chronic Kidney Disease in Peritoneal Dialysis on Residual Kidney Function: In Real-World Data. Medicina 2024, 60, 1198. https://doi.org/10.3390/medicina60081198

AMA Style

Moral Berrio E, De La Flor JC, Arambarri Segura M, Rodríguez-Doyágüez P, Martínez Calero A, Zamora R, Cieza-Terrones M, Yuste-Lozano C, Sánchez de la Nieta García MD, Nieto Iglesias J, et al. Effects of Sodium–Glucose Cotransporter 2 Inhibitors in Diabetic and Non-Diabetic Patients with Advanced Chronic Kidney Disease in Peritoneal Dialysis on Residual Kidney Function: In Real-World Data. Medicina. 2024; 60(8):1198. https://doi.org/10.3390/medicina60081198

Chicago/Turabian Style

Moral Berrio, Esperanza, José C. De La Flor, Minerva Arambarri Segura, Pablo Rodríguez-Doyágüez, Alberto Martínez Calero, Rocío Zamora, Michael Cieza-Terrones, Claudia Yuste-Lozano, María Dolores Sánchez de la Nieta García, Javier Nieto Iglesias, and et al. 2024. "Effects of Sodium–Glucose Cotransporter 2 Inhibitors in Diabetic and Non-Diabetic Patients with Advanced Chronic Kidney Disease in Peritoneal Dialysis on Residual Kidney Function: In Real-World Data" Medicina 60, no. 8: 1198. https://doi.org/10.3390/medicina60081198

APA Style

Moral Berrio, E., De La Flor, J. C., Arambarri Segura, M., Rodríguez-Doyágüez, P., Martínez Calero, A., Zamora, R., Cieza-Terrones, M., Yuste-Lozano, C., Sánchez de la Nieta García, M. D., Nieto Iglesias, J., & Vozmediano Poyatos, C. (2024). Effects of Sodium–Glucose Cotransporter 2 Inhibitors in Diabetic and Non-Diabetic Patients with Advanced Chronic Kidney Disease in Peritoneal Dialysis on Residual Kidney Function: In Real-World Data. Medicina, 60(8), 1198. https://doi.org/10.3390/medicina60081198

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