Electroacupuncture on the Scalp over the Motor Cortex Ameliorates Behavioral Deficits Following Neonatal Hypoxia-Ischemia in Rats via the Activation of Neural Stem Cells
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Neonatal Hypoxia–Ischemia Model
2.3. Electroacupuncture Treatment
2.4. Brdu Labeling
2.5. Open Field Test
2.6. Cylinder Test
2.7. Rotarod Test
2.8. Passive Avoidance Test
2.9. Immunofluorescence Staining
2.10. Nissl Staining
2.11. Data Analyses
3. Results
3.1. Effects of EA Treatment on Motor and Memory Functions Following Hypoxia-Ischemia
3.2. Effects of EA Treatment on the Corpus Callosum Thickness, Oligodendrocytes, and Astrocytes
3.3. Effects of EA Treatment on Neurogenesis in the Subventricular Zone and Hippocampus
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Jung, D.H.; Pak, M.E.; Lee, H.J.; Ahn, S.M.; Yun, Y.J.; Shin, Y.-I.; Shin, H.K.; Lee, S.-Y.; Choi, B.T. Electroacupuncture on the Scalp over the Motor Cortex Ameliorates Behavioral Deficits Following Neonatal Hypoxia-Ischemia in Rats via the Activation of Neural Stem Cells. Life 2020, 10, 240. https://doi.org/10.3390/life10100240
Jung DH, Pak ME, Lee HJ, Ahn SM, Yun YJ, Shin Y-I, Shin HK, Lee S-Y, Choi BT. Electroacupuncture on the Scalp over the Motor Cortex Ameliorates Behavioral Deficits Following Neonatal Hypoxia-Ischemia in Rats via the Activation of Neural Stem Cells. Life. 2020; 10(10):240. https://doi.org/10.3390/life10100240
Chicago/Turabian StyleJung, Da Hee, Malk Eun Pak, Hong Ju Lee, Sung Min Ahn, Young Ju Yun, Yong-Il Shin, Hwa Kyoung Shin, Seo-Yeon Lee, and Byung Tae Choi. 2020. "Electroacupuncture on the Scalp over the Motor Cortex Ameliorates Behavioral Deficits Following Neonatal Hypoxia-Ischemia in Rats via the Activation of Neural Stem Cells" Life 10, no. 10: 240. https://doi.org/10.3390/life10100240