Kinetic and Equilibrium Studies of Doxorubicin Adsorption onto Carbon Nanotubes
Abstract
:1. Introduction
2. Results and Discussion
2.1. Qualitative and Quantitative Determination of Surface Functional Groups on Modified Multiwall Carbon Nanotubes
2.1.1. Zeta Potential
2.1.2. Energy-Dispersive X-ray Spectroscopy
2.1.3. Thermogravimetric Analysis and Differential Scanning Calorimetry
2.2. Adsorption of DOX on Carbon Nanotubes
2.2.1. Computer Simulation for Adsorption of DOX on CNTs
2.2.2. Adsorption Isotherm of DOX Adsorption on Pristine MWCNTs and Modified MWCNTs
2.2.3. Kinetics of Adsorption
2.2.4. Mechanism of Adsorption
3. Experimental
3.1. Materials
Functionalization of MWCNTs
3.2. Methods
3.2.1. Thermal Analysis
3.2.2. UV–VIS Spectroscopy
3.2.3. Zeta Potential
3.2.4. Adsorption of DOX on Functionalized MWCNTs
3.2.5. Determination of Adsorption Kinetics
3.2.6. Molecular Dynamics Simulations
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Material | Carbon (wt %) | Nitrogen (wt %) | Oxygen (wt %) | Chlorine (wt %) |
---|---|---|---|---|
MWCNTs | 97.84 | 1.22 | 0.94 | 0.00 |
modified MWCNTs | 95.75 | 1.46 | 2.79 | 0.00 |
DOX-MWCNTs | 74.28 | 3.36 | 17.42 | 3.52 |
DOX | 64.10 | 3.85 | 25.84 | 6.21 |
Freundlich | Langmuir | Temkin | |||||||
---|---|---|---|---|---|---|---|---|---|
1/n | kF | R2 | qmax mg g−1 | KL mL g−1 | R2 | b kJ mol−1 | kt mL g−1 | R2 | |
Pristine MWCNTs | 0.1725 ± 0.009 | 64.99 ± 6.10 | 0.9918 | 185.2 ± 20.4 | 0.0492 ± 0.004 | 0.9985 | 0.104 ± 0.009 | 4.70 ± 0.04 | 0.9891 |
Modified MWCNTs | 0.8234 ± 0.063 | 42.61 ± 8.53 | 0.9658 | - | - | - | 0.00165 ± 0.00053 | 0.0464 ± 0.009 | 0.8750 |
Kinetic Model | Parameters | Values |
---|---|---|
Pseudo-first order | qe/mg g−1 | 2290 ± 173 |
k1/min−1 | 0.0110 ± 0.0009 | |
R2 | 0.915 | |
Pseudo-second order | qe/mg g−1 | 4029 ± 241 |
k2/g mg−1 min−1 | 6.92 × 10−5 ± 0.16 × 10−5 | |
R2 | 0.999 | |
Intra-particle diffusion | k1/mg g−1 min −1/2 | 1058.6 ± 62.9 |
C1/mg g−1 | 82.59 ± 2.4 | |
R2 | 0.991 | |
k2/mg g−1 min −1/2 | 77.12 ± 1.7 | |
C2/mg g−1 | 317.0 ± 21.3 | |
R2 | 0.903 | |
Fractional power | v | 0.283 ± 0.09 |
KFP | 1264.4 ± 74.4 | |
R2 | 0.859 | |
Elovich model | α/mg g−1 min −1 | 4136.2 ± 167.7 |
β/g mg−1 | 0.001537 ± 0.00001 | |
R2 | 0.904 |
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Chudoba, D.; Łudzik, K.; Jażdżewska, M.; Wołoszczuk, S. Kinetic and Equilibrium Studies of Doxorubicin Adsorption onto Carbon Nanotubes. Int. J. Mol. Sci. 2020, 21, 8230. https://doi.org/10.3390/ijms21218230
Chudoba D, Łudzik K, Jażdżewska M, Wołoszczuk S. Kinetic and Equilibrium Studies of Doxorubicin Adsorption onto Carbon Nanotubes. International Journal of Molecular Sciences. 2020; 21(21):8230. https://doi.org/10.3390/ijms21218230
Chicago/Turabian StyleChudoba, Dorota, Katarzyna Łudzik, Monika Jażdżewska, and Sebastian Wołoszczuk. 2020. "Kinetic and Equilibrium Studies of Doxorubicin Adsorption onto Carbon Nanotubes" International Journal of Molecular Sciences 21, no. 21: 8230. https://doi.org/10.3390/ijms21218230