The Progress of Stem Cell Technology for Skeletal Regeneration
Abstract
:1. Introduction
2. Skeletal Development in Embryos
2.1. Paraxial Mesoderm
2.1.1. Development of the Paraxial Mesoderm in Embryo
2.1.2. Recapitulating Development of the Paraxial Mesoderm in a Dish
2.1.3. Chondrocyte Differentiation through the Paraxial Mesoderm in a Dish
2.1.4. Osteoblast Differentiation through the Paraxial Mesoderm in a Dish
2.2. Lateral Plate Mesoderm
2.2.1. Development of the Lateral Plate Mesoderm in Embryo
2.2.2. Recapitulating Development of the Lateral Plate Mesoderm in a Dish
2.2.3. Chondrocyte and Osteoblast Differentiation through the Lateral Plate Mesoderm in a Dish
2.3. Neural Crest
2.3.1. Development of the Neural Crest in Embryo
2.3.2. Recapitulating Development of the Neural Crest and Its Derivatives in a Dish
3. MSCs
4. SSCs
5. CAR Cells
6. Summary and Future Perspectives
Funding
Conflicts of Interest
References
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Cell Type | Condition | Method | Cell Source | Phase |
---|---|---|---|---|
iPS (1) | Knee articular cartilage damage | Implantation of iPSC-derived Cartilage | Alogenic (iPSCs) | N/A |
MSC (2) | Knee articular cartilage damage | Arthroscopy, Microfracture | Autologus (synovium) | N/A |
MSC (3) | Knee osteoarthritis | Intra-articular injection | Autologus (bone marrow) | 1 |
MSC (4) | Knee osteoarthritis | Transplantation with high tibial osteotomy | Alogenic (umbilical cord blood) | 2 |
MSC (5) | Knee osteoarthritis | Intra-articular injection | Autologus (adipose, bone marrow) | 3 |
MSC (6) | Knee osteoarthritis | Intra-articular injection | Autologus (adipose) | 4 |
MSC (7) | Osteoporotic Spinal fracture | Intravenous Infusion | Autologus (bone marrow) | 1 |
MSC (8) | Nonunion of Fracture | Injection at the fracture site | Autologus (adipose) | 1, 2 |
MSC (9) | Nonunion of Fracture | Implantation with biomaterial | Autologus (bone marrow) | 3 |
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Tani, S.; Okada, H.; Chung, U.-i.; Ohba, S.; Hojo, H. The Progress of Stem Cell Technology for Skeletal Regeneration. Int. J. Mol. Sci. 2021, 22, 1404. https://doi.org/10.3390/ijms22031404
Tani S, Okada H, Chung U-i, Ohba S, Hojo H. The Progress of Stem Cell Technology for Skeletal Regeneration. International Journal of Molecular Sciences. 2021; 22(3):1404. https://doi.org/10.3390/ijms22031404
Chicago/Turabian StyleTani, Shoichiro, Hiroyuki Okada, Ung-il Chung, Shinsuke Ohba, and Hironori Hojo. 2021. "The Progress of Stem Cell Technology for Skeletal Regeneration" International Journal of Molecular Sciences 22, no. 3: 1404. https://doi.org/10.3390/ijms22031404