Molecular Genetic Regulation and Precision Breeding Strategies for Economically Important Traits in Poultry

A special issue of Agriculture (ISSN 2077-0472). This special issue belongs to the section "Farm Animal Production".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 913

Special Issue Editors

College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Interests: poultry; genetics and breeding; gene function; epigenetics; molecular-marker-assisted breeding; adipogenesis
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Guest Editor
College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450002, China
Interests: chicken; epigenomics; genomic selection; multi-omics; gene regulation; structural variation; genome-wide association study
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Meeting escalating global demands for poultry products with enhanced yield efficiency, disease resilience, and superior meat/egg quality represents a pivotal challenge in modern animal agriculture. In this context, molecular genetic insights into economically critical traits—such as growth efficiency, feed conversion, disease resistance, and product quality—are fundamental to advancing precision breeding frameworks. Harnessing modern omics technologies are imperative to decode the biological mechanisms underpinning these traits and translate discoveries into sustainable breeding solutions.

This Special Issue focuses on integrating molecular genetics with precision breeding strategies to optimize economically vital traits in poultry species (chickens, turkeys, ducks, etc.). We seek interdisciplinary research bridging genetics, genomics, bioinformatics, and biotechnology to (1) elucidate genetic/epigenetic regulation of key traits; (2) develop gene-editing applications; (3) implement genomic selection and marker-assisted breeding; and (4) explore novel biomarkers for trait phenotyping. All types of articles, such as original research, opinions, and reviews, are welcome.

Dr. Tao Zhang
Prof. Dr. Zhuanjian Li
Guest Editors

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Keywords

  • precision poultry breeding
  • quantitative trait loci
  • phenomics
  • epigenomics
  • genomic selection
  • gene editing
  • multi-omics

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Published Papers (1 paper)

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Research

13 pages, 2451 KB  
Article
Breed-Based Genome-Wide CNV Analysis in Dong Tao Chickens Identifies Candidate Regions Potentially Related to Robust Tibia Morphology
by Hao Bai, Dandan Geng, Weicheng Zong, Yi Zhang, Guohong Chen and Guobin Chang
Agriculture 2026, 16(2), 221; https://doi.org/10.3390/agriculture16020221 - 15 Jan 2026
Viewed by 530
Abstract
Tibia morphology is a significant factor in poultry germplasm and market traits. Copy number variation (CNV) has been identified as a structural source of genetic variation for complex traits. We profiled genome-wide CNVs in Dong Tao chickens and nine other local breeds and [...] Read more.
Tibia morphology is a significant factor in poultry germplasm and market traits. Copy number variation (CNV) has been identified as a structural source of genetic variation for complex traits. We profiled genome-wide CNVs in Dong Tao chickens and nine other local breeds and performed a breed-based case–control CNV-GWAS (Dong Tao vs. reference breeds). We sequenced 152 chickens, including 46 Dong Tao, and annotated genes and pathways. A total of 22,972 CNVs were detected, of which 2193 were retained after filtration across 33 chromosomes, with sizes ranging from 2 kilobases to 12.8 megabases. Principal component analysis indicated an overall weakness in the breed structure and a sex-related trend within Dong Tao. A deletion on chromosome 3 at 36,529,501 to 36,539,000 was observed in Dong Tao. The exploratory screen identified 44 CNV regions at nominal significance (p < 0.05), distinguishing Dong Tao from other breeds. Thirty-seven regions contained 99 genes, including CHRM3 within the chromosome 3 deletion and CRADD overlapping two CNVs. Enrichment analysis indicated thiamine metabolism and growth hormone receptor signalling as the primary pathways of interest, with TPK1, SOCS2, and FHIT identified as potential candidates. These results provide a CNV landscape for Dong Tao and prioritize variant regions and pathways potentially relevant to its robust tibia morphology; however, no direct CNV–tibia phenotype regression was performed. Full article
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