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Animals
Special Issues
Developmental and Reproductive Toxicity of Nanoparticles in Animals
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Developmental and Reproductive Toxicity of Nanoparticles in Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Reproduction".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 916

Special Issue Editor

Dr. Fenglei Chen

E-Mail Website
Guest Editor
College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
Interests: nanoparticles; nanotoxicology; cytotoxicity; developmental toxicity; reproductive toxicity; acute toxicity; subchronic toxicity; chronic toxicity; toxic mechanism

Special Issue Information

Dear Colleagues,

Owing to the development of nanotechnology, nano-materials have developed rapidly in the animal husbandry and veterinary industries. Due to their mature synthesis process, good stability, favorable surface modifications, special hollow structures, large specific surface areas, and strong adsorption capacity, nanoparticles (NPs) have been widely used in feed additives, veterinary drugs, and animal vaccines. However, NPs can be toxic, with their toxicity level depending mainly on their physicochemical properties. Owing to their small particle size, NPs are able to penetrate the physiological barrier and enter the blood circulation to reach various organs and accumulate in non-target tissues, leading to acute and chronic toxicity. More and more studies have revealed NP-induced developmental and productive toxicity, including testicular toxicity, ovarian toxicity, and others. In light of concerns about reproductive toxicity, the Editors of Animals are setting up a Special Issue with the title of “Developmental and Reproductive Toxicity of Nanoparticles in Animals”. Dr. Fenglei Chen will serve as Guest Editor for the above-mentioned Special Issue. Submissions can include original research articles and comprehensive reviews related to this title. This Special Issue will be published from the issue date, and the duration is 1 year.

Dr. Fenglei Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • nanotoxicology
  • cytotoxicity
  • developmental toxicity
  • reproductive toxicity
  • acute toxicity
  • subchronic toxicity
  • chronic toxicity
  • toxic mechanism

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Published Papers (1 paper)

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Research

21 pages, 16172 KiB  
Article
Taurine Protects against Silica Nanoparticle-Induced Apoptosis and Inflammatory Response via Inhibition of Oxidative Stress in Porcine Ovarian Granulosa Cells
by Fenglei Chen, Jiarong Sun, Rongrong Ye, Tuba Latif Virk, Qi Liu, Yuguo Yuan and Xianyu Xu
Animals 2024, 14(20), 2959; https://doi.org/10.3390/ani14202959 - 14 Oct 2024
Viewed by 672
Abstract
Silica nanoparticles (SNPs) induce reproductive toxicity through ROS production, which significantly limits their application. The protective effects of taurine (Tau) against SNP-induced reproductive toxicity remain unexplored. So this study aims to investigate the impact of Tau on SNP-induced porcine ovarian granulosa cell toxicity. [...] Read more.
Silica nanoparticles (SNPs) induce reproductive toxicity through ROS production, which significantly limits their application. The protective effects of taurine (Tau) against SNP-induced reproductive toxicity remain unexplored. So this study aims to investigate the impact of Tau on SNP-induced porcine ovarian granulosa cell toxicity. In vitro, granulosa cells were exposed to SNPs combined with Tau. The localization of SNPs was determined by TEM. Cell viability was examined by CCK-8 assay. ROS levels were measured by CLSM and FCM. SOD and CAT levels were evaluated using ELISA and qPCR. Cell apoptosis was detected by FCM, and pro-inflammatory cytokine transcription levels were measured by qPCR. The results showed that SNPs significantly decreased cell viability, while increased cell apoptosis and ROS levels. Moreover, SOD and CAT were decreased, while IFN-α, IFN-β, IL-1β, and IL-6 were increased after SNP exposures. Tau significantly decreased intracellular ROS, while it increased SOD and CAT compared to SNPs alone. Additionally, Tau exhibited anti-inflammatory effects and inhibited cell apoptosis. On the whole, these findings suggest that Tau mitigates SNP-induced cytotoxicity by reducing oxidative stress, inflammatory response, and cell apoptosis. Tau may be an effective strategy to alleviate SNP-induced toxicity and holds promising application prospects in the animal husbandry and veterinary industry. Full article
(This article belongs to the Special Issue Developmental and Reproductive Toxicity of Nanoparticles in Animals)
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