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Animals
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Osteosarcoma in Companion Animals
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Osteosarcoma in Companion Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 2674

Special Issue Editor

Prof. Dr. Joaquim Henriques

E-Mail Website
Guest Editor
Faculty of veterinary Medicine, University Lusófona, 1749-024 Lisbon, Portugal
Interests: veterinary oncology; comparative oncology; carcinoma; cancer; osteosarcoma; bone tumors

Special Issue Information

Dear Colleagues,

Osteosarcoma is the most common malignant bone tumor found in dogs. Indeed, while much less common in cats, it still accounts for around 70% of cancerous bone tumors in felines.

The present standard of care includes surgery and adjuvant medical therapy and offers a survival time of around one year, with metastatic disease being the principal cause of death in dogs. Metastatic spread in cats is rarer than in dogs. As such, surgical intervention, when it is possible, can allow feline osteosarcoma patients to live relatively normally after surgical treatment.

Despite the significant improvements in canine veterinary oncology regarding tumor prevention, early detection, diagnosis, and treatment made over recent decades, unfortunately for dogs affected by osteosarcoma, these advances have not changed the therapeutic and prognostic landscape as considerably as in other canine cancers.

Herein, we invite scholars to submit original research and review papers that discuss novel and innovative approaches to the diagnosis, staging, treatment, and comparative aspects of osteosarcoma in companion animals to this Special Issue, which aims to highlight potential areas of interest for future research questions.

Prof. Dr. Joaquim Henriques
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteosarcoma
  • bone tumor
  • companion animal
  • dog
  • canine
  • cat
  • feline
  • sarcoma

Published Papers (2 papers)

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Research

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18 pages, 927 KiB  
Article
Pilot Clinical Trial to Evaluate In Situ Calcium Phosphate Cement Injection for Conservative Surgical Management of Appendicular Osteosarcoma in Dogs
by Céline Molle, Aquilino Villamonte-Chevalier, Julien Carabalona, Aurélia Klajer, Julien Letesson, Guillaume Ragetly, Bertrand Védrine, Juliette Blondiau and Olivier Gauthier
Animals 2024, 14(10), 1460; https://doi.org/10.3390/ani14101460 - 14 May 2024
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Abstract
Cementoplasty is a minimally invasive procedure that consists of injecting a bone substitute into the tumor lesion to provide bone reinforcement and alleviate pain. This study aimed to demonstrate the feasibility, safety, and efficacy of cementoplasty with a calcium phosphate cement in osteosarcoma [...] Read more.
Cementoplasty is a minimally invasive procedure that consists of injecting a bone substitute into the tumor lesion to provide bone reinforcement and alleviate pain. This study aimed to demonstrate the feasibility, safety, and efficacy of cementoplasty with a calcium phosphate cement in osteosarcoma to reduce pain and preserve limb function. Throughout the 6-month study, dogs received no adjuvant therapy, and dogs’ evaluations included a clinical examination, monitoring of postoperative complications, radiographic follow-up, and assessment of limb function and pain scores. Out of 12 dogs enrolled, 10 were withdrawn before study completion due to deterioration in their general condition. Nine (9) dogs were followed until D28, six until D56, and two until D183. Compared to D0, more than 50% of the dogs showed improvement in both veterinarian and owner scores at their final visit. Throughout the study, 10 major and 4 minor complications were reported, all unrelated to the procedure. This open non-controlled study provides first evidence of the feasibility, safety, and efficacy of cementoplasty procedure using a calcium phosphate bone cement to relieve pain and preserve limb function in dogs suffering from appendicular osteosarcoma. Full article
(This article belongs to the Special Issue Osteosarcoma in Companion Animals)
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10 pages, 2958 KiB  
Case Report
Vertebral Osteosarcoma in Two Cats—Diagnosis, Treatment, and Outcome
by Koen Maurits Santifort, Martijn Beukers, Arno Roos, Benjamin van Rijswoud, Nadine Meertens, Klaas Peperkamp, Ron Ben-Amotz and Niklas Bergknut
Animals 2023, 13(22), 3478; https://doi.org/10.3390/ani13223478 - 10 Nov 2023
Viewed by 1369
Abstract
In this case report, we describe the diagnosis, treatment, and outcome of two feline cases of vertebral osteosarcoma. Case 1: A 6-year-old female neutered domestic longhaired cat was presented with progressive paraparesis, ataxia, and spinal hyperesthesia. MRI of the thoracolumbar spinal cord and [...] Read more.
In this case report, we describe the diagnosis, treatment, and outcome of two feline cases of vertebral osteosarcoma. Case 1: A 6-year-old female neutered domestic longhaired cat was presented with progressive paraparesis, ataxia, and spinal hyperesthesia. MRI of the thoracolumbar spinal cord and vertebral column revealed a strongly contrast-enhancing mass lesion originating from the dorsal lamina and spinous process of T13. The lesion caused extradural compression of the spinal cord. Surgical debulking was performed, and the histopathological evaluation of surgical biopsies was consistent with vertebral osteosarcoma. The cat was paraplegic with intact nociception post-surgery. Subsequently, the cat recovered ambulation while remaining mildly ataxic and paraparetic at long-term follow-up. Post-operative chemotherapy was started with doxorubicin. CT scans at 2, 4, 9, 13, and 20 months post-surgery showed no signs of local recurrence or metastasis. Case 2: A 15.5-year-old male neutered domestic shorthaired cat was presented with progressive paraparesis, tail paresis, and spinal hyperesthesia. Radiographs and CT scan of the lumbar vertebral column showed a large mass originating from the dorsal lamina and spinous process of L6, suggestive of neoplasia, with severe compression of the spinal cord. Surgical debulking was performed, and the histopathological evaluation was consistent with vertebral osteosarcoma. Post-operative chemotherapy was started with doxorubicin. Seven months post-surgery, the patient was neurologically normal with no signs of metastatic disease. This case report highlights the possibility of good outcomes after the surgical treatment of feline vertebral osteosarcoma supplemented with post-surgical chemotherapy. Full article
(This article belongs to the Special Issue Osteosarcoma in Companion Animals)
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