Pathogenic Processes in Animal Infectious Diseases

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 3305

Special Issue Editor


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Guest Editor
Dipartimento di Sanità animale, Istituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy
Interests: infectious diseases; bacteria; virus; genetics; proteomics; molecular biology; diagnostic systems; immunity; mastitis

Special Issue Information

Dear Colleagues,

In the last ten years, interest in animal infectious diseases has increased, based on the worldwide distribution of diseases with a detrimental impact on farm animals and the rise of zoonotic diseases, such as influenza; moreover, there has been increasing interest in the association of viruses with tumor development. The development of diagnostic and prophylactic tools is pivotal for containing the diffusion of infectious diseases and the understanding of pathogenic processes is essential for the identification of biomarkers. Since pathogenesis is a dynamic and composite process, the study of both pathogens and hosts and their relationship has a key role in clarifying the mechanisms of disease development. The Special Issue brings together new insights in animal infectious disease processes, with highlights in host immune response, identification of antigens and virulence factors, description of viral oncogenic proteins and/or processes, and the new diagnostic methods. Both original research papers and reviews are welcome.

Dr. Carla Cacciotto
Guest Editor

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Keywords

  • infectious diseases
  • virulence factors
  • immune response
  • host-pathogen interaction
  • oncogenesis

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Published Papers (1 paper)

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Research

12 pages, 727 KiB  
Article
Reduction in Pathogenicity in Yeast-like Fungi by Farnesol in Quail Model
by Nadezhda Sachivkina, Elena Vasilieva, Ekaterina Lenchenko, Olga Kuznetsova, Arfenia Karamyan, Alfia Ibragimova, Natalia Zhabo and Maria Molchanova
Animals 2022, 12(4), 489; https://doi.org/10.3390/ani12040489 - 16 Feb 2022
Cited by 29 | Viewed by 2687
Abstract
Candida albicans was the first eukaryotic microorganism to exhibit quorum-sensing through the secretion of the sesquiterpene E, farnesol. This molecule is generated by dephosphorylation of farnesyl pyrophosphate in the mevalonate biosynthetic pathway in mammalian and yeast cells. Exogenous farnesol inhibits yeast-to-hyphal formation in [...] Read more.
Candida albicans was the first eukaryotic microorganism to exhibit quorum-sensing through the secretion of the sesquiterpene E, farnesol. This molecule is generated by dephosphorylation of farnesyl pyrophosphate in the mevalonate biosynthetic pathway in mammalian and yeast cells. Exogenous farnesol inhibits yeast-to-hyphal formation in a concentration- and time-dependent manner at the earliest stage of hyphal development. Much research has been devoted to studying the role of farnesol as an inhibitor of hyphal morphogenesis; however, little research has been published regarding the in vivo impacts of farnesol on fungal virulence and the development of Candida infection. While other studies have examined the impact of multiple doses of farnesol in addition to antimycotics, we hypothesize that C. albicans treated with a single dose of this quorum-sensing molecule could reduce fungal virulence in a quail model. Full article
(This article belongs to the Special Issue Pathogenic Processes in Animal Infectious Diseases)
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