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Animals
Special Issues
Neurodegenerative Diseases in Animals—Mechanisms, Onset and Therapeutic Options
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Neurodegenerative Diseases in Animals—Mechanisms, Onset and Therapeutic Options

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 8046

Special Issue Editors

Prof. Dr. Charles H. Vite

E-Mail Website
Guest Editor
University of Pennsylvania School of Veterinary Medicine, 3800 Spruce St, Philadelphia, PA 19104, USA
Interests: neurodegenerative diseases; Niemann-Pick type C disease; neurology; neuroscience; feline and canine models; gene therapy; canine epilepsy
Dr. Amy L. Johnson

E-Mail Website
Guest Editor
New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA 19348, USA
Interests: equine neurology

Special Issue Information

Dear Colleagues,

The degeneration of the central and peripheral nervous systems may affect animals of any age due to genetic, metabolic, or toxic causes, in addition to degeneration’s known association with aging.  In this Special Issue we will focus on neurodegenerative diseases in veterinary species with specific attention paid to cerebellar degenerations, cognitive dysfunction syndrome, Parkinson disease, lysosomal storage disorders, degenerative myelopathy, spinal muscular atrophy, motor neuron disease,  dysautonomia, and neuraxonal dystrophy.  The purpose of this issue is to provide up-to-date information on pathophysiology, clinical phenotype, diagnosis, and therapy of these disorders from experts in the field.

Prof. Dr. Charles H. Vite
Dr. Amy L. Johnson
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurodegeneration
  • lysosomal storage disease
  • dysautonomia
  • axonopathy
  • abiotrophy

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Published Papers (1 paper)

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Research

16 pages, 2839 KiB  
Article
Recovery of Spinal Walking in Paraplegic Dogs Using Physiotherapy and Supportive Devices to Maintain the Standing Position
by Mădălina Elena Henea, Eusebiu Viorel Șindilar, Liviu Cătălin Burtan, Iuliana Mihai, Mariana Grecu, Alina Anton and Gheorghe Solcan
Animals 2023, 13(8), 1398; https://doi.org/10.3390/ani13081398 - 19 Apr 2023
Cited by 1 | Viewed by 7268
Abstract
Paraplegic patients have always been ideal candidates for physiotherapy due to their body’s inability to recover on its own. Regardless of the cause that led to the onset of paraplegia (traumatic or degenerative), physiotherapy helps these patients with devices and methods designed to [...] Read more.
Paraplegic patients have always been ideal candidates for physiotherapy due to their body’s inability to recover on its own. Regardless of the cause that led to the onset of paraplegia (traumatic or degenerative), physiotherapy helps these patients with devices and methods designed to restore the proper functioning of their motility, as well as their quality of life. A total of 60 paraplegic dogs without deep pain in the hindlimbs caused by intervertebral disc extrusion or thoracolumbar fractures underwent physiotherapy sessions: manual therapy (massage), electrostimulation (10–20 min with possible repetition on the same day), ultrasound therapy, laser therapy, hydrotherapy, and assisted gait in supportive devices or on treadmills to stimulate and relearn walking, which was the main focus of the study. To maintain the standing position over time, we developed different devices adapted for each patient depending on the degree of damage and the possible associated pathologies: harnesses, trolleys, straps, exercise rollers, balancing platforms and mattresses, physio balls and rollers for recovery of proprioception. The main objective of our study was to demonstrate that physiotherapy and assisted gait in supportive devices to maintain the standing position may help paraplegic dogs to develop spinal walking. Concurrent pathologies (skin wounds, urinary infections, etc.) were managed concomitantly. Recovery of SW was evaluated by progression in regaining the reflectivity, nociception, gait score, and quality of life. After 125 to 320 physiotherapy sessions (25 to 64 weeks), 35 dogs (58.33%) developed spinal walking and were able to walk without falling or falling only sometimes in the case of a quick look (gait score 11.6 ± 1.57, with 14 considered normal), with a lack of coordination between the thoracic and pelvic limbs or difficulties in turning, especially when changing direction, but with the recovery of the quadrupedal position in less than 30 s. The majority of dogs recovering SW were of small size, with a median weight of 6.83 kg (range: 1.5–15.7), mixed breed (n = 9; 25.71%), Teckel (n = 4; 11.43%), Bichon (n = 5; 14.28%), Pekingese (n = 4; 11.43%), and Caniche (n = 2; 5.71%), while those who did not recover SW were larger in size, 15.59 kg (range: 5.5–45.2), and mixed breed (n = 16; 64%). Full article
(This article belongs to the Special Issue Neurodegenerative Diseases in Animals—Mechanisms, Onset and Therapeutic Options)
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