Ovine Genetics: Utilizing OMIC Tools to Design Ovine Breeds for the Future

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Small Ruminants".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 4824

Special Issue Editor


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Guest Editor
Departamento de Mejora Genética Animal, INIA Ctra de la Coruña, Madrid, Spain
Interests: animal genetics; molecular genetics; genomic selection; adaptive traits; reproductive metagenomics.

Special Issue Information

Dear Colleagues,

Over the last decade, the overall amount of sheep production has grown worldwide. To improve the sustainability and competitiveness of sheep livestock systems through breeding, new phenotypes linked to sustainable animal productivity can be developed and integrated into breeding schemes to allow for the selection of animals that are resilient and adaptable to current and future environmental challenges. In the last few decades, novel measures targeting economically important traits through phenotypes linked to physiological processes of animals such as body reserve utilization, feed efficiency, metabolic diseases, thermo-tolerance, methane emissions, disease resistance, and reproductive efficiency have been developed. These new phenotypes are costly and difficult to collect and generally have low heritability. Current genomic tools may help to provide information about genetic loci involved in the phenotypic variation of these complex traits and may be integrated into traditional breeding programs in order to improve their ability to cope with new selection objectives.

Dr. Malena Serrano Noreña
Guest Editor

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Keywords

  • sheep breeds
  • new phenotypes
  • adaptive traits
  • resilience
  • omic tools
  • genomic selection.

Published Papers (1 paper)

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Research

11 pages, 1376 KiB  
Article
Genome-Wide Association Studies of Somatic Cell Count in the Assaf Breed
by Yasemin Öner, Malena Serrano, Pilar Sarto, Laura Pilar Iguácel, María Piquer-Sabanza, Olaia Estrada, Teresa Juan and Jorge Hugo Calvo
Animals 2021, 11(6), 1531; https://doi.org/10.3390/ani11061531 - 24 May 2021
Cited by 6 | Viewed by 3275
Abstract
A genome-wide association study (GWAS) was performed to identify new single nucleotide polymorphisms (SNPs) and genes associated with mastitis resistance in Assaf sheep by using the Illumina Ovine Infinium® HD SNP BeadChip (680K). In total, 6173 records from 1894 multiparous Assaf ewes [...] Read more.
A genome-wide association study (GWAS) was performed to identify new single nucleotide polymorphisms (SNPs) and genes associated with mastitis resistance in Assaf sheep by using the Illumina Ovine Infinium® HD SNP BeadChip (680K). In total, 6173 records from 1894 multiparous Assaf ewes with at least three test day records and aged between 2 and 7 years old were used to estimate a corrected phenotype for somatic cell score (SCS). Then, 192 ewes were selected from the top (n = 96) and bottom (n = 96) tails of the corrected SCS phenotype distribution to be used in a GWAS. Although no significant SNPs were found at the genome level, four SNPs (rs419096188, rs415580501, rs410336647, and rs424642424) were significant at the chromosome level (FDR 10%) in two different regions of OAR19. The SNP rs419096188 was located in intron 1 of the NUP210 and close to the HDAC11 genes (61 kb apart), while the other three SNPs were totally linked and located 171 kb apart from the ARPP21 gene. These three genes were related to the immune system response. These results were validated in two SNPs (rs419096188 and rs424642424) in the total population (n = 1894) by Kompetitive Allele-Specific PCR (KASP) genotyping. Furthermore, rs419096188 was also associated with lactose content. Full article
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