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Animals
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Advances in pig reproductions
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Advances in pig reproductions

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Reproduction".

Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 3534

Special Issue Editors

Dr. Domenico Ventrella

E-Mail Website
Guest Editor
Department of Veterinary Medical Sciences, Alma Mater Studiorum Univeristy of Bologna， via Tolara di sopra 50, 40064 Ozzano Emilia (BO), Italy
Interests: physiology of reproduction; reproductive biotechnologies; semen quality; pig reproduction; translational medicine
Dr. Alberto Elmi

E-Mail Website
Guest Editor
Department of Veterinary Medical Sciences, University of Bologna, 40126 Bologna, Italy
Interests: veterinary physiology; reproductive physiology; endocrinology; wild species; laboratory animals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Due to the constantly increasing demand for pork products, pig reproduction represents a very hot topic for scientists and breeders working in the field. As a consequence, in recent decades, a wide variety of biotechnological strategies have been developed and tested, in order to try and maximize the reproductive capabilities of pigs. Problems to be faced include, among the others, seasonal hypo/infertility, long-term semen storage, excessive artificial insemination dose supplementation with antibiotics, etc. Moreover, as pigs share a high number of physiological traits with humans, research in the reproductive field may also provide information translatable to humans.

The scope of the Special Issue focuses on advances in every field of pig reproduction, with a special emphasis on the physiology of reproduction itself, new biotechnologies for semen storage and artificial insemination and animal husbandry to improve fertility and reproductive outcomes.

Dr. Domenico Ventrella
Dr. Alberto Elmi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pig reproduction
  • semen quality
  • fertility
  • reproductive biotechnologies

Published Papers (1 paper)

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Research

13 pages, 2669 KiB  
Article
miR-126 Controls the Apoptosis and Proliferation of Immature Porcine Sertoli Cells by Targeting the PIK3R2 Gene through the PI3K/AKT Signaling Pathway
by Xiangwei Tang, Yao Chen, Hui Luo, Qiao Bian, Bo Weng, Anqi Yang, Dan Chu, Maoliang Ran and Bin Chen
Animals 2021, 11(8), 2260; https://doi.org/10.3390/ani11082260 - 30 Jul 2021
Cited by 6 | Viewed by 2191
Abstract
The quantity of Sertoli cells in the adult testis decides the daily gamete formation, and accumulating evidence indicates that epigenetic factors regulate the proliferation of Sertoli cells. Research on the function and regulatory mechanism of microRNAs (miRNAs) in Sertoli cells has not been [...] Read more.
The quantity of Sertoli cells in the adult testis decides the daily gamete formation, and accumulating evidence indicates that epigenetic factors regulate the proliferation of Sertoli cells. Research on the function and regulatory mechanism of microRNAs (miRNAs) in Sertoli cells has not been comprehensive yet, especially on domestic animals. In this article, we report that miR-126 controls the proliferation and apoptosis of immature porcine Sertoli cells based on previous studies. Our results confirmed that miR-126 elevation promotes cell cycle progression, cell proliferation and represses cell apoptosis; on the contrary, the inhibitory effects of miR-126 result in the opposite. The phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2) gene, a member of the PI3K family, was verified as a direct target of miR-126 using the dual-luciferase reporter analysis. miR-126 negatively regulated the mRNA and protein expression level of PIK3R2 in immature porcine Sertoli cells. siRNA-induced PIK3R2 inhibition caused similar effects as miR-126 overexpression and eliminated the influences of miR-126 knockdown in immature porcine Sertoli cells. In addition, both miR-126 overexpression and PIK3R2 inhibition elevated the phosphorylation of PI3K and AKT, whereas the miR-126 knockdown demonstrated the contrary result. In short, miR-126 controls the proliferation and apoptosis of immature porcine Sertoli cells by targeting the PIK3R2 gene through the PI3K/AKT signaling pathway. The research supplies a theoretical and practical foundation for exploring the functional parts of miR-126 in swine sperm by defining the destiny of immature Sertoli cells. Full article
(This article belongs to the Special Issue Advances in pig reproductions)
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