Intrinsic and Acquired Antimicrobial Resistance in Salmonella

Dear Colleagues,

Salmonella is a common zoonotic pathogen found in a wide variety of animals, where it either causes disease or colonizes the intestinal tract. Human disease through direct or indirect animal contact and foodborne outbreaks is common. The most important species is Salmonella enterica (subspecies enterica) with its more than 2000 serovars. Depending on the specific serovar, antimicrobial resistance is quite common. In humans, but also in animals, a generalized salmonellosis is often life-threatening and requires antimicrobial treatment. Children under the age of six months are most susceptible and can acquire generalized salmonellosis from many different serovars. Treatment options are clearly limited when the disease is caused by multidrug-resistant Salmonella, and the spread of such clones in the food and feed environment is a concern. Both acquired and intrinsic resistant mechanisms in Salmonella are important for the spread within and between different serovars, species and even closely related genera. The emerging transmission of resistance mechanisms has already led to cross-border disease outbreaks such as of the Salmonella serovar Typhimurium DT104. Whole-genome sequence data and their analysis can help to verify emerging and concerning antimicrobial resistance in this pathogen, anticipate future challenges, and find strategies to combat this important pathogen.

In this Special Issue, original research articles and reviews in this research area are welcome. We look forward to receiving your contributions.

Dr. Friederike Hilbert
Guest Editor

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