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Antibiotics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Efflux Pumps in Bacteria: What They Do and How We Can Stop Them

edited by

Tommaso Felicetti

submission deadline 15 May 2025 | 8 articles | Viewed by 35188 | Submission Open

Keywords: new antibiotics; bioactive medicinal agents; classes of antibiotics; antibiotic resistance and misuse; natural antibiotics; microbial efflux pumps; efflux pump inhibitors

(This special issue belongs to the Section Antibiofilm Strategies)

Antibiotics Resistance in Gram-Negative Bacteria, 2nd Edition

edited by

Simone Simionatto

submission deadline 15 May 2025 | 7 articles | Viewed by 16549 | Submission Open

Keywords: antimicrobial resistance; epidemiology; genomics surveillance; One-Health; enterobacteriaceae; repurposing; bacteriophages; antimicrobial peptides; natural compounds; virulence profiles

The Search for Antimicrobial Agents from Natural Products

edited by Carolina P. Reyes and

Antonio Francioso

submission deadline 15 May 2025 | 6 articles | Viewed by 12874 | Submission Open

Keywords: natural products; antimicrobial agents; drug discovery; mechanism of action; pharmacology

(This special issue belongs to the Section Plant-Derived Antibiotics)

Antimicrobial Treatment and Management of Central Nervous System Infections

edited by Liana Signorini and Angelo Pan

submission deadline 15 May 2025 | 5 articles | Viewed by 10145 | Submission Open

Keywords: central nervous system; CNS; hospital-acquired infection; nosocomial; neurosurgery; external ventricular drainage; EVD; post-neurosurgical meningitis; bacterial colonization

Machine Learning for Antimicrobial Resistance Prediction, 2nd Edition

edited by

Asad Mustafa Karim

submission deadline 15 May 2025 | 1 articles | Viewed by 2582 | Submission Open

Keywords: antimicrobial resistance prediction; artificial intelligence; machine learning; infectious diseases

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

What’s New: Natural and Synthetic Antibacterials and/or Agents with Multiple Activities? (3rd Edition)

edited by

Maria Stefania Sinicropi

submission deadline 15 May 2025 | 1 articles | Viewed by 2415 | Submission Open

Keywords: natural antibacterials; synthetic antibacterials; antitumorals; antivirals; antioxidants; antifungals; anti-inflammatory

(This special issue belongs to the Section Novel Antimicrobial Agents)

Therapeutic Drug Monitoring of Antimicrobials in Critically Ill Patients

edited by Young Ran Lee

submission deadline 15 May 2025 | 1 articles | Viewed by 1915 | Submission Open

Keywords: therapeutic drug monitoring (TDM); antibiotics; antimicrobials; pharmacokinetic; pharmacodynamic; critically ill

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics of Drugs)

Clostridioides difficile Infection, 3rd Edition

edited by

Guido Granata

submission deadline 15 May 2025 | 1 articles | Viewed by 1858 | Submission Open

Keywords: Clostridioides difficile; Clostridioides difficile infection recurrence; antimicrobial use; host and microbiota interaction; CDI

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Genomic Analysis of Drug-Resistant Pathogens

edited by

Erica Diani

submission deadline 20 May 2025 | 2 articles | Viewed by 3488 | Submission Open

Keywords: multi-drug resistant; mutation; bacteria; NGS; sequencing; mobile genetics elements; gene transfer

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Carbapenem-Resistant Enterobacteriaceae: Epidemiology, Detection and Treatment

edited by Seung Soon Lee

submission deadline 20 May 2025 | Viewed by 153 | Submission Open

Keywords: carbapenem-resistant Enterobacterales (CRE); antibiotic treatment; epidemiology

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Detection of Bacteria and Antibiotics Surveillance in Livestock

edited by

Danijela Horvatek Tomić

submission deadline 30 May 2025 | 10 articles | Viewed by 11045 | Submission Open

Keywords: livestock; bacteria; pathogens; antibiotic resistance; antibiotic surveillance; zoonoses

(This special issue belongs to the Section Antibiotics in Animal Health)

Bioactive Peptides and Their Antibiotic Activity

edited by

Hamilton Cabral

submission deadline 30 May 2025 | 5 articles | Viewed by 9261 | Submission Open

Keywords: database peptides; therapeutic agents; peptide design; antimicrobial peptides; antibiotic resistance; therapeutic drugs

(This special issue belongs to the Section Antimicrobial Peptides)

Pharmacokinetic and Antibiotic Dosing for Intensive Care Unit Patients

edited by

Yuhki Sato

submission deadline 31 May 2025 | 8 articles | Viewed by 22286 | Submission Open

Keywords: antibiotics; pharmacokinetics-pharmacodynamics; therapeutic drug monitoring; population pharmacokinetics analysis; bacterial susceptibility

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics of Drugs)

Nanoparticles as Antibacterial/Antibiofilm Agents

edited by

J. Scott VanEpps

submission deadline 31 May 2025 | 7 articles | Viewed by 21584 | Submission Open

Keywords: nanoparticles; antibacterial; biofilm; mechanism; antibiotic resistance

(This special issue belongs to the Section Antimicrobial Materials and Surfaces)

Phage Applications from Diagnostics to Treatment of Bacterial Infections in a One Health World

edited by

Mariagrazia Di Luca

and

Goran Vukotic

submission deadline 31 May 2025 | 8 articles | Viewed by 20369 | Submission Open

Keywords: phage therapy; antibiotic resistance; bacteriophages; regulatory framework; veterinary medicine; agriculture treatment; aquaculture

(This special issue belongs to the Section Bacteriophages)

Microbial Resistance to Carbapenems: Epidemiology, Detection and Treatment Options

edited by

Vasiliki Koumaki

and

Efthymia Protonotariou

submission deadline 31 May 2025 | 9 articles | Viewed by 19321 | Submission Open

Keywords: carbapenems; carbapenemases; Gram-negatives; multidrug resistance (MDR); carpabenem-resistant organisms (CROs); antimicrobial resistance; carbapenem resistance detection; epidemiology; antibiotics; carbapenem-resistant Gram-negative bacteria (CRGNB)

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Successful Antimicrobial Stewardship Approaches to Address Nosocomial Infections

edited by

Eduardo Rodríguez-Noriega

submission deadline 31 May 2025 | 6 articles | Viewed by 17829 | Submission Open

Keywords: bacterial; resistance; antimicrobial; stewardship

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antimicrobial Resistance and Epidemiological Study of Clinically Relevant Pathogens

edited by

Florin George Horhat

Adrian Man

and

Delia Muntean

submission deadline 31 May 2025 | 8 articles | Viewed by 17257 | Submission Open

Keywords: antibacterial activity; antimicrobial resistance; infections; multidrug-resistant pathogens; virulence gene expression; drug discovery; epidemiological study

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antimicrobial Prescribing, Population Use and Resistance, Impact in Global Health, 2nd Edition

edited by

Juan Manuel Vázquez-Lago

Ana Estany-Gestal

and

Angel Salgado-Barreira

submission deadline 31 May 2025 | 11 articles | Viewed by 14961 | Submission Open

Keywords: epidemiology; social behavior; antibiotic resistance; social factors; attitudes; knowledge; practice; qualitative research; public health interventions; antibiotic prescription; community care

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antibiotic Use in Outpatients and Hospitals

edited by

Rosario Cultrera

submission deadline 31 May 2025 | 7 articles | Viewed by 14630 | Submission Open

Keywords: antimicrobial resistance; outpatient; epidemiology; in hospital infections; antibiotic stewardship; source control; antibiotic prescribing

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antibiofilm Activity against Multidrug-Resistant Pathogens

edited by

Verica Aleksic Sabo

and Petar Knezevic

submission deadline 31 May 2025 | 6 articles | Viewed by 14048 | Submission Open

Keywords: biofilm; microbial drug resistance; antibiofilm agents; antibiofilm strategies; synergistic interactions

(This special issue belongs to the Section Antibiofilm Strategies)

Insights into Natural Antimicrobial Peptides

edited by

András Fodor

Eustachio Tarasco

and

Maurizio Francesco Brivio

submission deadline 31 May 2025 | 4 articles | Viewed by 11603 | Submission Open

Keywords: antibacterial host defense peptides; antibacterial mode of action; defensins; cathelicidins; insect antimicrobial peptides; plant antimicrobial peptides

(This special issue belongs to the Section Antimicrobial Peptides)

Antibiotic Resistance and Coping Strategies of Methicillin-Resistant Staphylococcus Species

edited by

Katarzyna Garbacz

submission deadline 31 May 2025 | 5 articles | Viewed by 9340 | Submission Open

Keywords: Staphylococcus aureus; methicillin resistance; MRSA; multidrug resistance; MDR; alternative therapies

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Molecular Mechanism of Antibiotic Resistance in Microbial Biofilms

edited by Patricia Pérez-Palacios

submission deadline 31 May 2025 | 4 articles | Viewed by 8969 | Submission Open

Keywords: biofilms; antibiotic resistance; resistance mechanisms

(This special issue belongs to the Section Antibiofilm Strategies)

Advancing the Discovery and Development of New Antibiotics through Drug Repurposing

edited by Songping Huang

submission deadline 31 May 2025 | 4 articles | Viewed by 8397 | Submission Open

(This special issue belongs to the Section Novel Antimicrobial Agents)

Evaluation of Emerging Antimicrobials

edited by

Dilep Kumar Sigalapalli

submission deadline 31 May 2025 | 4 articles | Viewed by 7992 | Submission Open

Keywords: antibacterials; antibiotics; antifungals; antimicrobial agents; antimicrobial resistance; antivirals; bacterial resistance; infections; multidrug resistance; pathogens

Antimicrobial Stewardship Intervention: Importance for Clinical Practice and Health Policy

edited by

Xiaolin Wei

and

Xiaoxv Yin

submission deadline 31 May 2025 | 4 articles | Viewed by 7625 | Submission Open

Keywords: antimicrobial stewardship; antibiotic use; implementation science; interventions; clinical guidelines; health policy

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Neonatal Infections: Epidemiology, Diagnostics and Antibiotic Therapeutics

edited by

Frans B. Plötz

submission deadline 31 May 2025 | 3 articles | Viewed by 6839 | Submission Open

Keywords: newborn; infant; neonate; infection; sepsis; early-onset sepsis; late-onset sepsis; antibiotics; antibiotic stewardship

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Nanomaterials as Antimicrobial Agents for Biomedical Applications

edited by

Gabriela Dorcioman

and

Valentina Grumezescu

submission deadline 31 May 2025 | 3 articles | Viewed by 6366 | Submission Open

(This special issue belongs to the Section Antimicrobial Materials and Surfaces)

Multitalented Synthetic Antimicrobial Compounds: From Design to Effect

edited by

Tsz Tin Yu

and

Maria Fernanda N. N. Carvalho

submission deadline 31 May 2025 | 4 articles | Viewed by 5743 | Submission Open

Keywords: antimicrobial resistance; antibiotic development; the design of antimicrobial compounds; the synthesis of antimicrobial compounds; medicinal chemistry; bioorganic chemistry; antimicrobial properties; the mechanisms of antimicrobial activity; bioinorganic

(This special issue belongs to the Section Novel Antimicrobial Agents)

Epidemiological Data on Antibiotic Resistance

edited by

Max Maurin

submission deadline 31 May 2025 | 2 articles | Viewed by 5633 | Submission Open

Keywords: antibiotic resistance; experimental models; antibiotic resistance selection; antibiotic resistance evolution pathways; antibiotic resistance phenotypes; antibiotic resistance genotypes; antibiotic resistance mechanisms; antibiotic resistance cost; antibiotic resistance prevention and control; antibiotic resistance reversion

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Metagenomics for Surveillance of Pathogens and/or Antimicrobial Resistance

edited by Rommel Thiago Jucá Ramos

submission deadline 31 May 2025 | 2 articles | Viewed by 5474 | Submission Open

Keywords: antimicrobial resistance; metagenomics; pathogen; environmental surveillance; clinical; one health

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antibiotic Use in the Communities—2nd Edition

edited by

Timo Juhani Lajunen

and

Mark Sullman

submission deadline 31 May 2025 | 6 articles | Viewed by 4992 | Submission Open

Keywords: antibiotic use; community; behavior; socioeconomic factors; culture; values

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Methods for Preventing Biofilm Formation and Treat the Infections Caused by Biofilm Formed on Biotics or Abiotic Surfaces

edited by

Cláudia Helena Silva-Lovato

and

Adriana Barbosa Ribeiro

submission deadline 31 May 2025 | 3 articles | Viewed by 4612 | Submission Open

Keywords: biofilms; infection; prevention; treatment

(This special issue belongs to the Section Antibiofilm Strategies)

Emerging Treatment Options for Multidrug-Resistant Bacterial and Fungal Infections, 2nd Edition

edited by

Andrea Marino

and

Stefano Stracquadanio

submission deadline 31 May 2025 | 2 articles | Viewed by 4586 | Submission Open

Keywords: MDR bacteria; antibiotic resistance; new antimicrobial; MDR fungi; antifungal therapies; alternative strategies

Bacteriophages and Phage-Derived Enzymes as Antibacterial Agents

edited by

Grzegorz Wegrzyn

submission deadline 31 May 2025 | 2 articles | Viewed by 2620 | Submission Open

Keywords: phage therapy; lytic bacteriophages; phage-derived enzymes; antibiotic resistance

(This special issue belongs to the Section Bacteriophages)

The Appropriateness of Antibiotic Prescribing in Hospitals and Ambulatory Care

edited by

Francesco Ferrara

, Roberto Langella and

Andrea Zovi

submission deadline 31 May 2025 | 1 articles | Viewed by 2609 | Submission Open

Keywords: pharmacology; antimicrobic resistance; governance; appropriateness; infectivology

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Single-Stage Management of Musculo-Skeletal Infections: Local Antibacterial Protection, Antibiotics, and Surgical Treatments

edited by

Guillem Bori

and

Carlo L. Romanò

submission deadline 31 May 2025 | 2 articles | Viewed by 2517 | Submission Open

Keywords: knee arthroplasty; hip arthroplasty; shoulder arthroplasty; antibiotic treatment; one-stage revision arthroplasty; antibacterial coating

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Mechanisms of Biofilm Development and Antibiofilm Therapeutics Strategies

edited by

Ruth Dudek-Wicher

and

Joanna Żur

submission deadline 31 May 2025 | 1 articles | Viewed by 1743 | Submission Open

Keywords: biofilm; polymicrobial biofilms; biofilm development; biofilm eradication; antibiofilm activity; targeted anti-biofilm therapy; EPS; quorum sensing; metabolic; AMP; biofilm penetration; enhanced antimicrobial therapy; multi-immunotherapy

(This special issue belongs to the Section Antibiofilm Strategies)

Genetic Mechanisms of Bacterial Survival: Antibiotic Resistance and Defense Strategies

edited by

Caio Augusto Martins Aires

and Thiago Pavoni Gomes Chagas

submission deadline 31 May 2025 | 1 articles | Viewed by 670 | Submission Open

Keywords: antimicrobial resistance mechanisms; disinfectant and antiseptic resistance; biofilm formation; genomic insights; horizontal gene transfer

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Therapy of Infectious Diseases Among Children and Adults: The Role of Antibiotics in Daily Practice

edited by

Magdalena Baymakova

and

Valeri R. Velev

submission deadline 31 May 2025 | Viewed by 655 | Submission Open

Keywords: аntibiotic use among children; аntibiotic use among adults; аntibiotic use among outpatients; аntibiotic use among inpatients; antibiotic resistance; improper antibiotic use; antibiotic quality control

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Combatting Dental Infections: Insights into Oral Microbiota and Antibiotic Therapy

edited by

Biao Ren

and

Jaya Seneviratne

submission deadline 31 May 2025 | Viewed by 432 | Submission Open

Keywords: oral microbiota; dental diseases; systematic disease; antimicrobial; therapeutic strategies; oral biomaterials; oral probiotics; infectious disease; oral microecology; targets

Optimizing Antimicrobial Therapy in NICU Settings: Strategies and Implications

edited by

Elias Iosifidis

and

Angeliki Kontou

submission deadline 31 May 2025 | Viewed by 308 | Submission Open

Keywords: neonatal ICU; antimicrobial stewardship; antimicrobial resistance; neonatal sepsis; biomarkers

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Global Perspectives on Antimicrobial Stewardship and Food Safety

edited by

Mahmoud Eltholth

submission deadline 31 May 2025 | Viewed by 240 | Submission Open

Keywords: antimicrobial resistance; antimicrobial use; food systems; food safety; antimicrobial stewardship

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Foodborne Pathogens: Detection, Resistance Mechanisms, and Control Strategies

edited by

Joana Campos

submission deadline 31 May 2025 | Viewed by 223 | Submission Open

Keywords: foodborne pathogens; antimicrobial resistance; rapid detection methods; control strategies; food safety interventions; One Health

Impact of Antimicrobial Stewardship on Healthcare-Associated Infections

edited by

Bojana Beović

submission deadline 31 May 2025 | Viewed by 134 | Submission Open

Keywords: antimicrobial stewardship; hospitals; antimicrobial resistance; antimicrobial stewardship interventions

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Advances in the Field of Biofilm-Associated Musculoskeletal Infections

edited by

Kordo Saeed

submission deadline 5 Jun 2025 | 1 articles | Viewed by 906 | Submission Open

Keywords: musculoskeletal infections; biofilm-associated; mycobacterial-associated; implant-related infections

(This special issue belongs to the Section Antibiofilm Strategies)

Design, Synthesis and Biological Evaluation of Antibacterial Compounds

edited by

Khondaker Miraz Rahman

submission deadline 15 Jun 2025 | 2 articles | Viewed by 3648 | Submission Open

Keywords: antibacterial agents; antifungal agents; antibiotics; antimicrobial resistance; drug discovery; medicinal chemistry

(This special issue belongs to the Section Novel Antimicrobial Agents)

Spread of Multidrug-Resistant Microorganisms, 2nd Edition

edited by

Mara Di Giulio

and

Silvia Di Lodovico

submission deadline 15 Jun 2025 | 1 articles | Viewed by 2772 | Submission Open

Keywords: multidrug-resistant organisms; MDR; antibiotic resistance gene; nosocomial infections; new marker of resistance

Antimicrobial Resistance in Biofilm-Associated Infections

edited by

Fazlurrahman Khan

Nazia Tabassum

and

Young-Mog Kim

submission deadline 15 Jun 2025 | 2 articles | Viewed by 1653 | Submission Open

Keywords: biofilms; antimicrobial resistance; chronic infections; biofilm matrix; virulence factors; antibiotic efficacy; pathogen persistence; biofilm formation; medical implants; quorum sensing

(This special issue belongs to the Section Antibiofilm Strategies)

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