Activity of Novel Antimicrobials against Gram-Negative Clinical Pathogens and Characterization of Their Resistance Mechanisms
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: closed (15 May 2024) | Viewed by 654
Special Issue Editors
2. Clinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy
Interests: antimicrobial resistance; AMR; Klebsiella pneumoniae; metallo-β-lactamases; β-lactamase inhibitor resistance; nosocomial outbreaks; plasmid-mediated resistance; fosfomycin resistance; molecular detection systems; antimicrobial susceptibility testing; carbapenemases; NDM; KPC
Special Issue Information
Dear Colleagues,
The increase in infections caused by bacterial pathogens resistant to most available antibiotics has a significant impact on global health. In 2016, the World Health Organization enumerated a priority list of 12 species for which the discovery of new antibiotics was urgently required, including multidrug-resistant and carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa, as well as carbapenem-resistant and/or third-generation cephalosporin-resistant Enterobacteriaceae. Therefore, in the last few years, several novel agents were approved by medicine regulatory agencies, while others are in late clinical development. The combination of new β-lactams with old β-lactamase inhibitors (BLIs), or the establishment of antibiotics with new BLIs, is the most general approach adopted, followed by the modification of the chemical structure of old antibiotics. The aim of this Special Issue is to promote the dissemination of studies evaluating the activity of novel antimicrobial agents against local and nationwide collections of Gram-negative clinical isolates. Studies characterizing resistance mechanisms responsible for the reduced activity of novel drugs will be prioritized. Surveillance studies are of paramount importance to monitor the emergence of novel antibiotic resistance and to provide useful data for the implementation of infection prevention and control and antibiotic stewardship measures.
Dr. Marco Coppi
Dr. Chaitanya Tellapragada
Guest Editors
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Keywords
- cefiderocol
- ceftolozane/tazobactam
- ceftazidime/avibactam
- aztreonam/avibactam
- meropenem/vaborbactam
- imipenem/relebactam
- plazomicin
- eravacycline
- cepefime/taniborbactam
- delafloxacin
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