Staphylococcus aureus Skin and Soft Tissue Infections Pathogenesis and Therapeutic Approaches, 2nd Edition

Dear Colleagues,

The first volume of the Special Issue “Staphylococcus aureus Skin and Soft Tissue Infections Pathogenesis and Therapeutic Approaches” was published in the beginning of 2024. It is a successful issue with seven published papers and has encouraged us to open a second volume with the same topic.

Staphylococcus aureus skin and soft tissue infections (SSTIs) represent a major threat to public health given the massive number of infections and the widespread emergence of antibiotic-resistant isolates, such as MRSA, both in the hospital and the community. Community-acquired MRSA is characterized by increased virulence and the capacity to initiate invasive staphylococcal infections even in healthy individuals. Moreover, whereas many SSTIs are relatively minor and self-limiting, complicated SSTIs can be life threatening. To address the increasing problems related to the actual management and treatment of SSTIs, novel approaches using either preventive or alternative therapeutic strategies are urgently needed. To this end, the understanding of SSTI pathogenesis is critical to develop new strategies that can contribute not only to efficiently eradicate the bacteria from the skin but also to decrease tissue damage as well as bacterial invasion and spread to the bloodstream. As a continuation of the Special Issue, this second volume will also aim to provide new insights into the complex interaction of S. aureus with the host in the skin microenvironment and in novel therapeutic approaches. Therefore, we invite original research articles and reviews that address the following topics:

• SSTI pathogenesis;
• Immune response to aureus in the skin;
• Current antimicrobial therapies to combat SSTI;
• Novel alternative strategies to eradicate aureus from the skin;
• Underlying diseases that predispose to SSTI;
• SSTI in immunocompromised patients;
• Staphylococcal differential gene expression in the skin microenvironment;
• Staphylococcal virulence factors and their regulators involved in SSTI;
• Microbial interactions in the skin.

Dr. Marisa I. Gómez
Dr. Cintia González
Dr. Constanza Giai
Guest Editors

Manuscript Submission Information

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• Staphylococcus aureus
• pathogenesis
• skin
• skin and soft tissue infections
• antimicrobial resistance
• adaptation
• host response

• Staphylococcus aureus Skin and Soft Tissue Infections Pathogenesis and Therapeutic Approaches in Antibiotics (7 articles)