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Antibiotics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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From Epidemiology to Intervention: Addressing the Spread of Multidrug-Resistant Microorganisms

edited by

Silvia Di Lodovico

submission deadline 30 Jul 2026 | 2 articles | Viewed by 1404 | Submission Open

Keywords: multidrug-resistant microorganisms; antimicrobial resistance; epidemiological surveillance; infection prevention and control; antimicrobial stewardship; one health; public health interventions

Gram-Positive Cocci: Antimicrobial Resistance, Treatment, Susceptibility, and New Therapeutic Options

edited by

Felipe Piedade Gonçalves Neves

submission deadline 30 Jul 2026 | Viewed by 885 | Submission Open

Keywords: Streptococcus spp.; Enterococcus spp.; Staphylococcus spp.; antimicrobial resistance; molecular epidemiology; new therapeutic options

From Detection to Treatment: Navigating Urinary Tract Infections with Antibiotics

edited by

Eleonora Nicolai

submission deadline 31 Jul 2026 | 4 articles | Viewed by 25203 | Submission Open

Advancing and Standardising Antimicrobial Susceptibility and Resistance Detection Methodology

edited by

Owen B. Spiller

submission deadline 31 Jul 2026 | 11 articles | Viewed by 20244 | Submission Open

Keywords: antimicrobial susceptibility testing; resistance screening; rapid diagnostics; clinical; veterinary; environmental; validation

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Advancing the Discovery and Development of New Antibiotics through Drug Repurposing

edited by Songping Huang

submission deadline 31 Jul 2026 | 7 articles | Viewed by 18598 | Submission Open

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antibiotic Resistance in Wastewater Treatment Plants

edited by Qingbin Yuan

submission deadline 31 Jul 2026 | 7 articles | Viewed by 15827 | Submission Open

Keywords: antibiotic resistance genes; wastewater treatment; one health; distribution and removal of ARGs; horizontal gene transfer

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Multitalented Synthetic Antimicrobial Compounds: From Design to Effect

edited by

Tsz Tin Yu

and

Maria Fernanda N. N. Carvalho

submission deadline 31 Jul 2026 | 6 articles | Viewed by 14904 | Submission Open

Keywords: antimicrobial resistance; antibiotic development; the design of antimicrobial compounds; the synthesis of antimicrobial compounds; medicinal chemistry; bioorganic chemistry; antimicrobial properties; the mechanisms of antimicrobial activity; bioinorganic

(This special issue belongs to the Section Novel Antimicrobial Agents)

The Antimicrobial Resistance in the Food Chain

edited by

Irene Dini

submission deadline 31 Jul 2026 | 5 articles | Viewed by 14369 | Submission Open

Keywords: food safety; foodborne pathogens; pathways of antimicrobial resistance; antibiotic resistance; phenotypic analyses; molecular analyses; regulatory guidelines; food chemistry

Global Strategies for Antimicrobial Surveillance: Country, Regional and Global Perspectives

edited by

Gustavo Horacio Marin

and Gabriel Levy-Hara

submission deadline 31 Jul 2026 | 8 articles | Viewed by 13305 | Submission Open

Keywords: antimicrobial; stewardship; resistance; consumption; use

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Neonatal Infection: Antibiotics for Prevention and Treatment

edited by Cinzia Auriti and Maria Paola Ronchetti

submission deadline 31 Jul 2026 | 6 articles | Viewed by 11508 | Submission Open

Keywords: neonatal infections; neonatal sepsis; sepsis definition; antibiotics in newborns; antibiotic stewardship; sepsis biomarkers; sepsis diagnosis in newborns; epidemiology of neonatal infections; fungal invasive infections

Clostridioides difficile Infection, 3rd Edition

edited by

Guido Granata

submission deadline 31 Jul 2026 | 4 articles | Viewed by 9911 | Submission Open

Keywords: Clostridioides difficile; Clostridioides difficile infection recurrence; antimicrobial use; host and microbiota interaction; CDI

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Biofilm-Associated Oral Diseases: Advances in Diagnosis and Challenges in Treatment

edited by

Naiera Zayed

and Cher Farrugia

submission deadline 31 Jul 2026 | 4 articles | Viewed by 8968 | Submission Open

Keywords: oral diseases; oral biofilms; host–biofilm interactions; novel antimicrobial strategies; molecular dynamics

(This special issue belongs to the Section Antibiofilm Strategies)

Innovations in Plant-Based Antibiotic and Antiviral Agents

edited by

Margherita-Gabriella De Biasi

and

Irene Dini

submission deadline 31 Jul 2026 | 4 articles | Viewed by 8795 | Submission Open

Keywords: secondary metabolites; phytochemicals; botanicals; analytical methods; toxicity

(This special issue belongs to the Section Plant-Derived Antibiotics)

Antifungal Strategies: Epidemiological Approaches, Mechanisms and Resistance in Fungal Pathogens

edited by

Erick Martinez-Herrera

Rodolfo Pinto-Almazán

and

Carmen Rodríguez-Cerdeira

submission deadline 31 Jul 2026 | 3 articles | Viewed by 7627 | Submission Open

Keywords: antifungal strategies; epidemiology; antifungal resistance; antifungal mechanisms; resistance genes

(This special issue belongs to the Section Fungi and Their Metabolites)

Diagnostics and Antibiotic Therapy in Bone and Joint Infections

edited by Sebastian Meller and Stavros Goumenos

submission deadline 31 Jul 2026 | 7 articles | Viewed by 6718 | Submission Open

Keywords: bone and joint infections; osteomyelitis; implant-related infections; diagnostics; antimicrobials; antibiotic therapy; PJI management; surgical site antisepsis; local antibiotic therapy; diagnostic biomarkers; multidisciplinary infection management; outcome analysis after musculoskeletal infection

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Gram-Negative Infections in Humans and Companion Animals: A Global Threat

edited by

Gabriele Meroni

submission deadline 31 Jul 2026 | 2 articles | Viewed by 4998 | Submission Open

Keywords: antimicrobial resistance; Gram-negative infections; humans; companion animals; essential oils; nanoparticles; pro-biotics; antimicrobial peptides; genomics; metagenomics

(This special issue belongs to the Section The Global Need for Effective Antibiotics)

Phage Therapy and Antimicrobial Innovation

edited by Ronen Hazan,

Lilach Gavish

and Amit Rimon

submission deadline 31 Jul 2026 | 4 articles | Viewed by 4716 | Submission Open

Keywords: antimicrobial resistance (AMR); antimicrobial innovation; phage therapy; phage engineering; synergistic strategies; chronic infections; biofilm; clinical phage microbiology; personalized medicine

(This special issue belongs to the Section Bacteriophages)

Evidence-Based Antibiotic Protocols and Digital Innovation in Oral Infection Management: Optimizing Use Through Teledentistry and Modern Diagnostics

edited by

Manlio Santilli

submission deadline 31 Jul 2026 | 3 articles | Viewed by 4367 | Submission Open

Keywords: antibiotics; dental infections; oral infections; antibacterial resistance; telemedicine; teledentistry; antimicrobial management; AI-related

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Advances in Antimicrobial Compounds: Exploring Natural, Synthetic, and Repositioned Drugs

edited by

Alessia Carocci

and Alexia Barbarossa

submission deadline 31 Jul 2026 | 3 articles | Viewed by 3818 | Submission Open

Keywords: antimicrobial compounds; natural products; synthetic agents; drug repositioning; antimicrobial resistance; synergistic approaches; mechanisms of action; drug development

(This special issue belongs to the Section The Global Need for Effective Antibiotics)

Epidemiology of Antimicrobial-Resistant Pathogens in Animals: A One Health Perspective

edited by

Francesco Pellegrini

Paolo Capozza

and

Marialaura Corrente

submission deadline 31 Jul 2026 | 5 articles | Viewed by 3804 | Submission Open

Keywords: antimicrobial resistance (AMR); veterinary epidemiology; one health; zoonotic pathogens; surveillance systems; molecular epidemiology; resistance mechanisms

(This special issue belongs to the Section Antibiotics in Animal Health)

Risks and Current Knowledge of Antimicrobial Resistance in Companion Animals

edited by

Djamel Drider

and

Raffaele Scarpellini

submission deadline 31 Jul 2026 | 2 articles | Viewed by 3009 | Submission Open

Keywords: antimicrobial resistance; companion animals; dogs; cats; clinically important antibiotics; One Health; reverse zoonosis; zoonosis; AMR epidemiology

(This special issue belongs to the Section Antibiotics in Animal Health)

Antimicrobial Biomaterials for Dentistry

edited by

Edith Lara-Carrillo

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2685 | Submission Open

Keywords: antimicrobials; dentistry; microorganisms; biomaterials; caries risk; oral environment; epidemiology

A Public Health Lens on Antibiotic Use: From Prescription to Resistance for ENT Infections

edited by

Palmira Immordino

and

Angelo Immordino

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2420 | Submission Open

Keywords: antibiotic resistance; ENT infections; public health; prescribing practices; overuse of antibiotics; diagnostic stewardship; patient education; otolaryngology; infection control

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antimicrobial Treatment and Antibiotic Use in Ophthalmology

edited by

Mark Willcox

submission deadline 31 Jul 2026 | 3 articles | Viewed by 1954 | Submission Open

Keywords: keratitis; conjunctivitis; antibiotics and combinations; antibiotic stewardship; antibiotic resistance; new therapies

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

From Nature to Laboratory Advances in Bioinspired Antimicrobial Drug Discovery

edited by

Cesar Augusto Roque-Borda

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1516 | Submission Open

Keywords: bioinspired antimicrobials; natural compounds; antimicrobial peptides; phytochemicals; peptidomimetics; hybrid conjugates; drug discovery; multidrug-resistant bacteria; controlled release; nanocarriers; structure–activity relationship; translational applications

(This special issue belongs to the Section Plant-Derived Antibiotics)

Alternative Approaches to Treating Antimicrobial Resistant Infections, 4th Edition

edited by

Michal Letek

and

Volker Behrends

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1374 | Submission Open

Keywords: repurposing; anti-infectives; host-targeted therapies; bacteriophages; predatory bacteria; bacteriocins; antimicrobial peptides; nanoparticles; natural compounds; immunotherapy; probiotics; antibiotics

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Foodborne Pathogens: The Rise of Virulence and Antimicrobial Resistance

edited by

Luisa Brito

and

Acacio Salamandane

submission deadline 31 Jul 2026 | Viewed by 638 | Submission Open

Keywords: foodborne pathogens; antimicrobial resistance; virulence factors; food chain; antibiotic overuse; public health; food safety; zoonotic diseases; one health

Biofilms and Implantable Device-Related Infections

edited by

Felipe Francisco Tuon

submission deadline 31 Jul 2026 | Viewed by 492 | Submission Open

Keywords: biofilm formation; implant-associated infections; medical devices; antimicrobial resistance; infection prevention

Honey: Antimicrobial and Anti-Infective Function, 2nd Edition

edited by

Niels Cremers

Juraj Majtan

and

José Miguel Álvarez-Suárez

submission deadline 31 Jul 2026 | Viewed by 487 | Submission Open

Keywords: antimicrobial activity; biofilms; infections; clinical applications; honey

(This special issue belongs to the Section Novel Antimicrobial Agents)

Sustainable Innovation in Antibiotic Adjuvants: Developing Strategies to Overcome Antibiotic Resistance and Biofilm Infections

edited by

Anabela Borges

and

Ana Cristina Oliveira Afonso

submission deadline 31 Jul 2026 | Viewed by 439 | Submission Open

Keywords: adjuvants; antibiotic resistance; biofilms; drug development; green chemistry; natural products; synergistic interactions

(This special issue belongs to the Section Biosynthesis and Combinatorial Approaches in Antimicrobial Discovery)

Dermatology and Wound Care: Antibiotics, Antimicrobial Therapy, Stewardship, and Resistance

edited by

Ayman Grada

submission deadline 31 Jul 2026 | Viewed by 343 | Submission Open

Keywords: dermatology; wound care; antibiotics; antimicrobials; antimicrobial resistance; antimicrobial stewardship; epidemiology; antimicrobial dressings

Translational Animal Models for Unraveling the Mechanisms of Action of Antimicrobial Peptides and Novel Antibiotics

edited by

Octávio L. Franco

and

Danieli Fernanda Buccini

submission deadline 31 Jul 2026 | Viewed by 334 | Submission Open

Keywords: antimicrobial resistance (AMR); translational research; animal models; preclinical studies; antimicrobial peptides (AMPs); novel antibiotics; pharmacokinetics/pharmacodynamics (PK/PD); in vivo efficacy; infection models; biofilm

(This special issue belongs to the Section Antimicrobial Peptides)

Cystic Fibrosis: Diagnosis and Antimicrobial Therapy in the CFTR Modulator Era

edited by Guergana Petrova

submission deadline 31 Jul 2026 | Viewed by 250 | Submission Open

Keywords: cystic fibrosis; bronchiectasis; advanced lung disease; Pseudomonas aeruginosa; glucose non-fermenting Gram negative bacteria; inhaled antibiotics; mchronic infection; biofilm; sweat test; CFTR-functional testing; genetics for cystic fibrosis

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Machine Learning for Antimicrobial Resistance Prediction, 2nd Edition

edited by

Asad Mustafa Karim

submission deadline 10 Aug 2026 | 3 articles | Viewed by 9332 | Submission Open

Keywords: antimicrobial resistance prediction; artificial intelligence; machine learning; infectious diseases

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antimicrobial Activity of Plants Against Emerging or Drug-Resistant Human Pathogens

edited by

Andrés H. Uc-Cachón

and

Gloria María Molina-Salinas

submission deadline 15 Aug 2026 | 8 articles | Viewed by 29169 | Submission Open

Keywords: anti-infective agents; antimicrobial activity; human pathogens; medicinal plants; natural products; phytodrugs

(This special issue belongs to the Section Plant-Derived Antibiotics)

Urinary Tract Infections and Antibiotic Intervention, 2nd Edition

edited by

Majid Mirzazadeh

submission deadline 20 Aug 2026 | 3 articles | Viewed by 6787 | Submission Open

Keywords: UTI; antibiotic; microbiome; PCR; next-generation sequencing; urine culture; enhanced quantitative urine cultures; urinary sepsis

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Clinical Pharmacokinetics, Pharmacodynamics, and/or TDM of Antimicrobial Agents

edited by

Yukihiro Hamada

submission deadline 31 Aug 2026 | 7 articles | Viewed by 24925 | Submission Open

Keywords: pharmacokinetics/pharmacodynamics; therapeutic drug monitoring; antimicrobial resistant; AI; antimicrobial stewardship

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics of Drugs)

Antimicrobial Properties of Essential Oils: Activities, Mechanisms, Applications, and Therapeutic Potential

edited by

Eduardo Valarezo

Miguel Ángel Meneses

and Matteo Radice

submission deadline 31 Aug 2026 | 3 articles | Viewed by 18464 | Submission Open

Keywords: antibiotics; antibacterial; antifungal; antiviral; ethnopharmacology; multidrug resistance; natural products; resistant strains; volatile secondary metabolites; volatile compounds

(This special issue belongs to the Section Plant-Derived Antibiotics)

Companion Animals: Antimicrobial Resistance in Bacterial and Fungal Pathogens Associated with Skin and Ear Infections

edited by

Dominik Łagowski

and

Ewelina Czyzewska-Dors

submission deadline 31 Aug 2026 | 7 articles | Viewed by 18104 | Submission Open

Keywords: dermatophytes; Candida; companion animals; drug susceptibility; Malassezia; mechanisms of resistance; molecular detection; Pseudomonas; Staphylococcus; One Health; MDR; veterinary

(This special issue belongs to the Section Antibiotics in Animal Health)

Antimicrobial Resistance from a One Health Perspective

edited by

Flávia L P. C. Pellegrino

submission deadline 31 Aug 2026 | 3 articles | Viewed by 13901 | Submission Open

Keywords: antimicrobial resistance mechanisms; bacterial virulence; clonal diversity; molecular epidemiology; antibiotic use; infectious diseases; One Health

Rational Use of Antibiotics in Veterinary Medicine

edited by

JeongWoo Kang

submission deadline 31 Aug 2026 | 2 articles | Viewed by 12848 | Submission Open

Keywords: good manufacturing practice (GMP) in antibiotic production; research and systems in antibiotic quality control; consequences of improper antibiotic use; antibiotic stewardship programs; antibiotic resistance management

(This special issue belongs to the Section Antibiotics in Animal Health)

Superbugs Unleashed: Global Challenges and Solutions for Extensively Drug-Resistant and Pan-Drug-Resistant Pathogens

edited by

Larisa Ionela Miftode

submission deadline 31 Aug 2026 | 3 articles | Viewed by 11345 | Submission Open

Keywords: antimicrobial resistance; extensively drug-resistant pathogens; pan-drug-resistant bacteria; multidrug-resistant organisms (MDROs); infectious disease control; antibiotic stewardship; novel antimicrobials; rapid diagnostics; global health threats

Antibiotic Surveillance and Rational Use in Special Populations: Enhancing Stewardship for Vulnerable Groups

edited by

Phumzile P Skosana

and

Filippo Mariano

submission deadline 31 Aug 2026 | 7 articles | Viewed by 9757 | Submission Open

Keywords: antibiotic stewardship; surveillance systems; special populations; rational use of antibiotics; infectious disease management

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Pharmacologic Management of MDR Respiratory and Bacteraemic Infections

edited by

Demosthènes A. Makris

and Konstantinos D. Mantzarlis

submission deadline 31 Aug 2026 | 5 articles | Viewed by 9038 | Submission Open

Keywords: pneumonia; bacteraemia; intensive care; MDR infections; antibiotics

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Evaluation of Emerging Antimicrobials, 2nd Edition

edited by

Dilep Kumar Sigalapalli

submission deadline 31 Aug 2026 | 4 articles | Viewed by 6996 | Submission Open

Keywords: antibacterials; antibiotics; antifungals; antimicrobial agents; antimicrobial resistance; antivirals; bacterial resistance; infections; multidrug resistance; pathogens

(This special issue belongs to the Section Novel Antimicrobial Agents)

Multi-Drug Resistant Gram-Negative Infections: Molecular Epidemiology, Microbiological Diagnosis, and Antimicrobial Treatment, 2nd Edition

edited by

Paolo Gaibani

submission deadline 31 Aug 2026 | 5 articles | Viewed by 6295 | Submission Open

Keywords: pharmacodynamics/pharmacokinetics (PK/PD); enterobacterales; carbapenemase; novel molecules; antimicrobial resistance

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Genomic Insights into Dissemination of Multi-Drug Resistance Pathogens

edited by

Vanessa Natália dos Santos Silva

and

Gilberto Igrejas

submission deadline 31 Aug 2026 | 3 articles | Viewed by 5974 | Submission Open

Keywords: antimicrobial resistance; genomic surveillance; MDR; gene transfer; One Health

Antimicrobial Agents for Drug-Resistant Infections: From Identification to Preclinical and Clinical Trials

edited by

Javier Eduardo García Castañeda

and

Zuly Jenny Rivera-Monroy

submission deadline 31 Aug 2026 | 2 articles | Viewed by 5327 | Submission Open

Keywords: antimicrobials agents; drug resistant; anti-cancerogenic agents; drug development; preclinical trials; clinical trials; pharmaceutical optimization

(This special issue belongs to the Section Novel Antimicrobial Agents)

Advances in Antimicrobial Action and Resistance

edited by

and

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3263 | Submission Open

Keywords: resistance; antibiotics; antimicrobials; one health; ethnopharmacology; stewardship; antimicrobial discovery; antimicrobial therapy; antimicrobial research

Bacterial Detection, Identification, and Antimicrobial Susceptibility Testing, 2nd Edition

edited by

Gabriele Bianco

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3070 | Submission Open

Keywords: identification methods; rapid diagnostics; MALDI-TOF MS; molecular testing; rapid antimicrobial susceptibility testing; antimicrobial susceptibility; synergy testing; β-lactam/β-lactamase inhibitor; fosfomycin; colistin

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