IgE in Autoimmunity

A special issue of Antibodies (ISSN 2073-4468).

Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 12843

Special Issue Editor


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Guest Editor
Centre de Recherche sur l’Inflammation-INSERM UMRS1149–CNRS ERL8252-Université de Paris; Team Basophils, Mast cells and Immunopathology; Laboratoire d’excellence Inflamex—DHU Fire-Faculté de Médecine Site Bichat, 16 rue Henri Huchard, Paris, France
Interests: IgE; basophils; autoimmunity; lupus nephritis; mast cells; translational research

Special Issue Information

Dear Colleagues,

Autoantibodies in autoimmune diseases are often described as major pathogenic factors. Depending on their isotype and/or their specificity, these autoantibodies can participate to either protective or deleterious pathophysiological mechanisms in various autoimmune diseases. IgE is well recognized as a pathogenic factor in IgE-mediated allergic diseases. Research from the last couple of decades could also demonstrate their key role in some autoimmune diseases. Some studies have identified total IgE and autoreactive IgE as involved in pathophysiology, as strong diagnostic and prognostic biomarkers, and/or as valuable therapeutic targets. Indeed, anti-IgE monoclonal antibody Omalizumab was tested in various autoimmune diseases and often showed promising therapeutic value. This Special Issue of Antibodies focuses on some autoimmune diseases where autoantibodies of the IgE isotype have been evidenced, with specific emphasis on different pathogenic mechanisms (specificity, immune complexes, cell types involved in their pathogenic effects, etc.), potential therapeutic targeting, and critical information that can be derived from the study of IgE autoantibodies.

Dr. Nicolas Charles
Guest Editor

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Keywords

  • Autoreactive IgE
  • IgE-mediated pathophysiology
  • Autoimmune diseases and related mechanisms
  • Type 2 immunity-driven autoimmune disease exacerbation

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Published Papers (2 papers)

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Review

12 pages, 859 KiB  
Review
IgE in the Pathogenesis of SLE: From Pathogenic Role to Therapeutic Target
by Yasmine Lamri and Nicolas Charles
Antibodies 2020, 9(4), 69; https://doi.org/10.3390/antib9040069 - 8 Dec 2020
Cited by 9 | Viewed by 5873
Abstract
Systemic lupus erythematosus (SLE) is a multifactorial chronic autoimmune disease, marked by the presence of autoantibodies to nuclear antigens belonging to different isotype classes. For several years, IgE antibodies have been incriminated in the development of allergic diseases and parasitic infections and different [...] Read more.
Systemic lupus erythematosus (SLE) is a multifactorial chronic autoimmune disease, marked by the presence of autoantibodies to nuclear antigens belonging to different isotype classes. For several years, IgE antibodies have been incriminated in the development of allergic diseases and parasitic infections and different anti-IgE therapies have been developed to encounter the pathogenic role of IgE in these pathologies. Recently, multiple studies showed the presence of elevated total IgE levels and demonstrated a pathogenic role of autoreactive IgE in SLE. This review aims to summarize the findings incriminating IgE and autoreactive IgE in the pathophysiology of SLE, to describe their functional outcomes on their targeted cells as well as to discuss different IgE-related therapeutic modalities that emerged and that may be beneficial for SLE patient care. Full article
(This article belongs to the Special Issue IgE in Autoimmunity)
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22 pages, 300 KiB  
Review
IgE Autoreactivity in Atopic Dermatitis: Paving the Road for Autoimmune Diseases?
by Christophe Pellefigues
Antibodies 2020, 9(3), 47; https://doi.org/10.3390/antib9030047 - 8 Sep 2020
Cited by 26 | Viewed by 6224
Abstract
Atopic dermatitis (AD) is a common skin disease affecting 20% of the population beginning usually before one year of age. It is associated with the emergence of allergen-specific IgE, but also with autoreactive IgE, whose function remain elusive. This review discusses current knowledge [...] Read more.
Atopic dermatitis (AD) is a common skin disease affecting 20% of the population beginning usually before one year of age. It is associated with the emergence of allergen-specific IgE, but also with autoreactive IgE, whose function remain elusive. This review discusses current knowledge relevant to the mechanisms, which leads to the secretion of autoreactive IgE and to the potential function of these antibodies in AD. Multiple autoantigens have been described to elicit an IgE-dependent response in this context. This IgE autoimmunity starts in infancy and is associated with disease severity. Furthermore, the overall prevalence of autoreactive IgE to multiple auto-antigens is high in AD patients. IgE-antigen complexes can promote a facilitated antigen presentation, a skewing of the adaptive response toward type 2 immunity, and a chronic skin barrier dysfunction and inflammation in patients or AD models. In AD, skin barrier defects and the atopic immune environment facilitate allergen sensitization and the development of other IgE-mediated allergic diseases in a process called the atopic march. AD is also associated epidemiologically with several autoimmune diseases showing autoreactive IgE secretion. Thus, a potential outcome of IgE autoreactivity in AD could be the development of further autoimmune diseases. Full article
(This article belongs to the Special Issue IgE in Autoimmunity)
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