Functional Proteomics in the Investigation of Protein-Protein Interactions
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: closed (20 March 2022) | Viewed by 632
Special Issue Editors
2.CEINGE-Biotecnologie Avanzate, Naples, Italy
Interests: proteomics; mass spectrometry; protein chemistry; biochemistry; protein-protein interactions
Interests: The scientific activity of Dr. Cozzolino initially addressed the structural characterization of proteins and their post-translational modifications using classical protein chemistry procedures in combination with advanced biomolecular mass spectrometric technologies. A successful strategy named epitope mapping based on the combination of enzymatic digestion and advanced mass spectrometric methodologies was applied in the investigation of antigen–antibody interaction surfaces. Today, the main scientific activity of Dr. Cozzolino is focused on proteomics studies on the elucidation of cell processes at molecular level both in physiological and pathological contests, using strategies based on immunoprecipitation and/or affinity purification for protein complex isolation and mass spectrometry-based approaches for protein identification and relative quantification. She is skilled in the management of LC-MS/MS systems employing identification of carotenoids and antioxidant agents and systems
Interests: Ms. Iacobucci’s research mainly focuses on the investigation of protein networks and differential protein expression to clarify cellular pathways in physiological as well as pathological conditions by functional and differential proteomics approaches applied to different scientific problems. She also studies in vitro protein–protein and protein–ligand complexes combining biochemical procedures and mass spectrometry techniques. She is also focused on systems biology approaches using bioinformatic tools for the analysis of proteomic data
Special Issue Information
Dear Colleagues,
Proteomics is the field of biochemical sciences that focuses on proteome characterization, including expression, structure, functions, interactions, and modifications of proteins at any stage. Today, proteomics investigations find large employment in all fields of biology, biotechnology, and in medicine for early disease diagnosis, prognosis, and monitoring disease development. The investigation of qualitative and quantitative variation in protein expression levels allows the description at molecular levels of the effects of the environmental condition changes, cellular stress sources, the presence of pathological states, drug treatments, etc. Analogously, a protein interatome’s analysis sheds light on its biological function by identifying protein–protein interactions (PPIs) and, therefore, the cell processes in which it is involved. Finally, applications of chemical proteomics are employed in drug discovery screening for target molecules’ identification.
In this Special Issue of Applied Sciences, the reader will find a topical selection of both research and review articles concerning the proteomics field applied in the investigation of molecular mechanisms at the basis of cell processes by exploring protein–protein interaction networks (functional proteomics). Furthermore, scientific contributions on the methodology, software, databases, and technological advances in the functional proteomic area are welcome. With the selected contributions, we would provide the reader with a comprehensive view of the recent proteomic applications and the direction in which this field is moving.
Prof. Dr. Maria Monti
Dr. Flora Cozzolino
Dr. Ilaria Iacobucci
Guest Editors
Manuscript Submission Information
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Keywords
- protein–protein interaction proteomics
- protein networks
- biomolecular mass spectrometry applications
