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Bioengineering
Special Issues
Osteoarthritis and Cartilage Tissue Repair
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Osteoarthritis and Cartilage Tissue Repair

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 3395

Special Issue Editors

Dr. Ilona Uzielienè

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Guest Editor
Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
Interests: cartilage regeneration; osteoarthritis; stem cell biology
Dr. Eiva Bernotiene

E-Mail Website
Guest Editor
Department of Regenerative, State Research Institute Centre for Innovative Medicine (IMC), Vilnius, Lithuania
Interests: human cartilage; chondrocytes; mesenchymal stem cells; chondrogenesis; ion channels; osteoarthritis; mechanotransduction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability across the world. Its incidence is rising due to aging, obesity, metabolic disorder and many more other factors. Degradation and loss of cartilage tissue is a hallmark of OA, which results in severe pain and impaired quality of life. Currently, there are no approved disease-modifying drugs developed for OA. In the absence of effective treatment, significant efforts are put into the development of biological drugs and cell-based therapies. This Special Issue focuses on various in vitro and in vivo models for cartilage repair during OA, which may include stem cells, different scaffolds/hydrogels, external stimuli such as mechanical compression or electrical stimulation, gene modifying strategies, etc. 

Dr. Ilona Uzielienè
Dr. Eiva Bernotiene
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteoarthritis
  • cartilage
  • regeneration
  • scaffolds
  • mechanical load
  • chondrocytes
  • stem cells
  • chondrogenic differentiation

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Published Papers (2 papers)

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17 pages, 3475 KiB  
Article
Menstrual Blood-Derived Stem Cell Paracrine Factors Possess Stimulatory Effects on Chondrogenesis In Vitro and Diminish the Degradation of Articular Cartilage during Osteoarthritis
by Ilona Uzieliene, Paulina Bialaglovyte, Rokas Miksiunas, Ignas Lebedis, Jolita Pachaleva, Raminta Vaiciuleviciute, Almira Ramanaviciene, Giedrius Kvederas and Eiva Bernotiene
Bioengineering 2023, 10(9), 1001; https://doi.org/10.3390/bioengineering10091001 - 24 Aug 2023
Cited by 1 | Viewed by 1523
Abstract
Articular cartilage is an avascular tissue with a limited capacity for self-regeneration, leading the tissue to osteoarthritis (OA). Mesenchymal stem cells (MSCs) are promising for cartilage tissue engineering, as they are capable of differentiating into chondrocyte-like cells and secreting a number of active [...] Read more.
Articular cartilage is an avascular tissue with a limited capacity for self-regeneration, leading the tissue to osteoarthritis (OA). Mesenchymal stem cells (MSCs) are promising for cartilage tissue engineering, as they are capable of differentiating into chondrocyte-like cells and secreting a number of active molecules that are important for cartilage extracellular matrix (ECM) synthesis. The aim of this study was to evaluate the potential of easily accessible menstrual blood-derived MSC (MenSC) paracrine factors in stimulating bone marrow MSC (BMMSCs) chondrogenic differentiation and to investigate their role in protecting cartilage from degradation in vitro. MenSCs and BMMSCs chondrogenic differentiation was induced using four different growth factors: TGF-β3, activin A, BMP-2, and IGF-1. The chondrogenic differentiation of BMMSCs was stimulated in co-cultures with MenSCs and cartilage explants co-cultured with MenSCs for 21 days. The chondrogenic capacity of BMMSCs was analyzed by the secretion of four growth factors and cartilage oligomeric matrix protein, as well as the release and synthesis of cartilage ECM proteins, and chondrogenic gene expression in cartilage explants. Our results suggest that MenSCs stimulate chondrogenic response in BMMSCs by secreting activin A and TGF-β3 and may have protective effects on cartilage tissue ECM by decreasing the release of GAGs, most likely through the modulation of activin A related molecular pathway. In conclusion, paracrine factors secreted by MenSCs may turn out to be a promising therapeutical approach for cartilage tissue protection and repair. Full article
(This article belongs to the Special Issue Osteoarthritis and Cartilage Tissue Repair)
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13 pages, 1037 KiB  
Protocol
Intra-Articular Injection of Adipose-Derived Stromal Vascular Fraction in Osteoarthritic Temporomandibular Joints: Study Design of a Randomized Controlled Clinical Trial
by Jan Aart M. Schipper, Aartje Jorien Tuin, Joris A. van Dongen, Nico B. van Bakelen, Martin Conrad Harmsen and Fred K. L. Spijkervet
Bioengineering 2024, 11(2), 171; https://doi.org/10.3390/bioengineering11020171 - 10 Feb 2024
Viewed by 1488
Abstract
Introduction: Temporomandibular joint (TMJ) osteoarthritis is a degenerative disease of the TMJ. It is characterized by progressive degradation of the extracellular matrix components of articular cartilage, with secondary inflammatory components leading to pain in the temporomandibular region and reduced mouth opening. Current treatments [...] Read more.
Introduction: Temporomandibular joint (TMJ) osteoarthritis is a degenerative disease of the TMJ. It is characterized by progressive degradation of the extracellular matrix components of articular cartilage, with secondary inflammatory components leading to pain in the temporomandibular region and reduced mouth opening. Current treatments do not halt disease progression, hence the need for new therapies to reduce inflammation and, consequently, improve symptoms. The aim of our randomized controlled clinical trial protocol is to investigate the efficacy of adjuvant intra-articular injections of autologous tissue-like stromal vascular fraction (tSVF), compared to arthrocentesis alone, in reducing pain and improving mouth opening in TMJ osteoarthritis patients. Materials and Methods: The primary endpoint analysis will consist of the visual analogue scale (VAS) for pain. The secondary endpoint analyses will include maximal interincisal mouth opening measurements; assessment of oral health and mandibular function based on the oral health impact profile (OHIP) questionnaire and mandibular functional impairment questionnaire (MFIQ); complications during the follow up; synovial cytokine analysis at baseline and after 26 weeks; and nucleated cells and tSVF (immuno)histochemistry analyses of the intervention group. Discussion: Our randomized clinical trial protocol will be applied to evaluate the efficacy of a new promising tSVF injection therapy for TMJ osteoarthritis. The safety of intra-articular injections of tSVF has been proven for knee osteoarthritis. However, since a tSVF injection is considered a heterologous application of cell therapy, the regulatory requirements are strict, which makes medical ethical approval challenging. Full article
(This article belongs to the Special Issue Osteoarthritis and Cartilage Tissue Repair)
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