Novel Fiber-Based Scaffolds for Tissue Engineering and Regenerative Medicine

Dear Colleagues,

We are preparing a Special Issue on “Novel fiber-based scaffolds for tissue engineering and regenerative medicine" to be published in Bioengineering. Tissue-engineered scaffolds aim to recapitulate the physiological environment of the extracellular matrix in vivo. This enables biomimetic mechanical and structural properties; proper transport of oxygen, nutrients, and metabolic waste; and, therefore, improved cellular behavior when exposed to the scaffold. Fiber-based scaffolds fabricated through spinning (electrospinning, centrifugal spinning, wet-spinning, melt-spinning, etc.), extrusion-based printing, and molding have attracted increasing attention in the last decade to address the above-mentioned requirements for bottom-up tissue reconstruction. Importantly, the control of the fiber fabrication and assembly approaches offers desired scaffold microstructure and anisotropy for the engineering of various tissues. Therefore, novel fiber-based scaffold fabrication approaches and biomaterial precursors, compatible with both the fabrication process and tissue culture, are needed for the reconstruction of functional tissue. 

The current Special Issue is focused on the recent advancements in the development of strategies for the fabrication of fiber-based scaffolds and their application for tissue engineering and regenerative medicine. Specifically, we aim to cover novel approaches enabling a controlled scaffold microstructure, multimaterial spatial distribution, and in vivo fabrication processes. Furthermore, the application of engineered tissues using fiber-based scaffolds for in vitro tissue modeling, regenerative medicine, and emerging fields such as cellular agriculture will be covered in this issue.

Dr. Mohamadmahdi Samandari
Dr. Mohsen Akbari
Guest Editors

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• tissue engineering
• regeneration
• electrospinning
• 3D (bio)printing
• wet spinning
• in vivo scaffold fabrication