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Nanoparticles and Hydrogel for Drug Delivery: Design and Synthesis
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Nanoparticles and Hydrogel for Drug Delivery: Design and Synthesis

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Drug Delivery".

Deadline for manuscript submissions: closed (20 October 2023) | Viewed by 6174

Special Issue Editors

Dr. Samira Malekmohammadi

E-Mail Website
Guest Editor
The Henry Royce Institute, University of Manchester, Royce Hub Building, Oxford Rd, Manchester M13 9PL, UK
Interests: drug delivery; biomaterials; tissue engineering; ultrasound therapy; silica particles
Special Issues, Collections and Topics in MDPI journals
Dr. Mohsen Akbari

E-Mail Website
Guest Editor
Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V9P 0C8, Canada
Interests: drug delivery; biomaterials; tissue engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Mohammad-Ali Shahbazi

E-Mail Website
Guest Editor
Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
Interests: biomaterials; drug delivery; cancer immunotherapy; photothermal therapy; tissue engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Rashid Jamshidi

E-Mail Website
Guest Editor
Department of Engineering, Manchester Metropolitan University, Manchester M1 5GD, UK
Interests: fluid dynamics; therapeutic ultrasound; sonodynamic therapy; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Delivery systems based on nanoparticles and hydrogels can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. These drug carriers can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs, and cells. Owing to their tunable physical properties, controllable degradability, and capability to protect labile drugs from degradation, hydrogels serve as a platform in which various physiochemical interactions with the encapsulated drugs control their release. 

The Special Issue on “Nanoparticles and Hydrogel for Drug Delivery: Design and Synthesis” is dedicated to recent developments in the synthesis, characterization, materials properties, and applications of different kinds of nanoparticles and gels in the design and fabrication of smart delivery systems. We welcome papers from multiple research fields, including novel composite synthetic routes and their applications in the medical and health industry.

Dr. Samira Malekmohammadi
Dr. Mohsen Akbari
Dr. Mohammad-Ali Shahbazi
Dr. Rashid Jamshidi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • hydrogel
  • drug delivery
  • design and synthesis
  • ultrasound drug delivery
  • microgels

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Published Papers (2 papers)

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Research

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13 pages, 5176 KiB  
Article
Functional L-Arginine Derivative as an Efficient Vector for Intracellular Protein Delivery for Potential Cancer Therapy
by Xiao He, Yannv Qu, Su Xiong, Zhiru Jiang, Yaqin Tang, Fei Yan, Yuanfei Deng and Yansun Sun
J. Funct. Biomater. 2023, 14(6), 301; https://doi.org/10.3390/jfb14060301 - 30 May 2023
Viewed by 1870
Abstract
The utilization of cytosolic protein delivery is a promising approach for treating various diseases by replacing dysfunctional proteins. Despite the development of various nanoparticle-based intracellular protein delivery methods, the complicated chemical synthesis of the vector, loading efficiency and endosomal escape efficiency of proteins [...] Read more.
The utilization of cytosolic protein delivery is a promising approach for treating various diseases by replacing dysfunctional proteins. Despite the development of various nanoparticle-based intracellular protein delivery methods, the complicated chemical synthesis of the vector, loading efficiency and endosomal escape efficiency of proteins remain a great challenge. Recently, 9-fluorenylmethyloxycarbonyl (Fmoc)-modified amino acid derivatives have been used to self-assemble into supramolecular nanomaterials for drug delivery. However, the instability of the Fmoc group in aqueous medium restricts its application. To address this issue, the Fmoc ligand neighboring arginine was substituted for dibenzocyclooctyne (DBCO) with a similar structure to Fmoc to obtain stable DBCO-functionalized L-arginine derivative (DR). Azide-modified triethylamine (crosslinker C) was combined with DR to construct self-assembled DRC via a click chemical reaction for delivering various proteins, such as BSA and saporin (SA), into the cytosol of cells. The hyaluronic-acid-coated DRC/SA was able to not only shield the cationic toxicity, but also enhance the intracellular delivery efficiency of proteins by targeting CD44 overexpression on the cell membrane. The DRC/SA/HA exhibited higher growth inhibition efficiency and lower IC50 compared to DRC/SA toward various cancer cell lines. In conclusion, DBCO-functionalized L-arginine derivative represents an excellent potential vector for protein-based cancer therapy. Full article
(This article belongs to the Special Issue Nanoparticles and Hydrogel for Drug Delivery: Design and Synthesis)
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Review

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29 pages, 2942 KiB  
Review
Bubble-Based Drug Delivery Systems: Next-Generation Diagnosis to Therapy
by Mihaela Kancheva, Lauren Aronson, Tara Pattilachan, Francesco Sautto, Benjamin Daines, Donald Thommes, Angela Shar and Mehdi Razavi
J. Funct. Biomater. 2023, 14(7), 373; https://doi.org/10.3390/jfb14070373 - 17 Jul 2023
Cited by 12 | Viewed by 3602
Abstract
Current radiologic and medication administration is systematic and has widespread side effects; however, the administration of microbubbles and nanobubbles (MNBs) has the possibility to provide therapeutic and diagnostic information without the same ramifications. Microbubbles (MBs), for instance, have been used for ultrasound (US) [...] Read more.
Current radiologic and medication administration is systematic and has widespread side effects; however, the administration of microbubbles and nanobubbles (MNBs) has the possibility to provide therapeutic and diagnostic information without the same ramifications. Microbubbles (MBs), for instance, have been used for ultrasound (US) imaging due to their ability to remain in vessels when exposed to ultrasonic waves. On the other hand, nanobubbles (NBs) can be used for further therapeutic benefits, including chronic treatments for osteoporosis and cancer, gene delivery, and treatment for acute conditions, such as brain infections and urinary tract infections (UTIs). Clinical trials are also being conducted for different administrations and utilizations of MNBs. Overall, there are large horizons for the benefits of MNBs in radiology, general medicine, surgery, and many more medical applications. As such, this review aims to evaluate the most recent publications from 2016 to 2022 to report the current uses and innovations for MNBs. Full article
(This article belongs to the Special Issue Nanoparticles and Hydrogel for Drug Delivery: Design and Synthesis)
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