CRISPR-Cas: Discovery, Function and Application
A special issue of Bioengineering (ISSN 2306-5354).
Deadline for manuscript submissions: closed (15 January 2021) | Viewed by 11909
Special Issue Editors
Interests: CRISPR; microbiology; biochemistry; gene regulation; epigenetics
Interests: CRISPR; microbiology; structural biology; biochemistry
Special Issue Information
CRISPR-Cas is a prokaryotic defense system that provides its host with an adaptive immunity against invading mobile genetic elements. These systems generally function by detecting foreign DNA or RNA based on complementarity to a small non-coding RNA guide to trigger a variety of nucleic acid degradation patterns for host protection. CRISPR-Cas systems are highly diverse in nature and recent efforts to optimize these systems through molecular engineering have converted CRISPR-Cas into a programmable “swiss-army” toolkit for biotechnological, therapeutic and diagnostic applications. With the increasing precision and safety of editing, CRISPR-Cas is not only being used for regular research but is also slowly approaching application in the clinic. In this special issue we will be interested but not limited to the following topics:
- Evolution and discovery of CRISPR-Cas systems
- Mechanisms of CRISPR-Cas function
- Natural regulation and control mechanisms of CRISPR activity
- Protein and RNA engineering approaches to achieve fine control of CRISPR-Cas activity
- Development of CRISPR-Cas based technologies for novel applications
- New and improved methods for the delivery of CRISPR tools
- Advances in alternative methods for genome editing
Dr. Haridha Shivram
Dr. Patrick Pausch
Dr. Xin D. Gao
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
