Nanosensors and Nanomodulators in Cancer Therapies
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanotechnology Applications in Bioengineering".
Deadline for manuscript submissions: 1 December 2024 | Viewed by 4478
Special Issue Editor
Special Issue Information
Dear Colleagues,
Diagnosing and training cancer with nanotechnology-based approaches is tremendously promising, as it can result in lower side effects and personalized interventions that lead to long-term disease remission. However, the effectiveness of nanotechnology-based approaches has not been consistent. A key variability driver in therapeutic responses is a current lack of technologies to design and implement personalized treatments.
The intersection of nanoscience with cancer therapies opens a world of new opportunities for personalized interventions. An incomplete list of such opportunities includes (1) ultrasensitive nanosensors detecting minute amounts of a biomarker, which could, in turn, enable the detection of multiple biomarkers out of a limited biopsy sample; (2) nanoparticles helping make a tumor visible to the physician, thus enhancing the possibility of successful surgical resection; (3) novel nanomaterials implanted in vivo to sequester biomarkers and/or cancer-relevant ligands to guide the synthesis of personalized treatments; (4) nanoparticles engineered in various architectures to help visualize therapy response or serve as patient-specific treatments, e.g., adeno-associated viruses, lentiviruses, lipid nanoparticles, and extracellular vesicles.
The current Special Issue emphasizes research at the intersection of nanosensing (devices) and nanomodulation (nanoparticles) for all aspects of cancer therapy, including diagnostic biomarker detection, validation of tumor targeting, and therapeutic response monitoring. It is highly encouraged that submitted manuscripts include a candid discussion of how the proposed technologies or methods could address current weaknesses in established interventions and describe the critical future milestones that would need to be attained to enable their successful translation to the clinic.
Prof. Dr. Georgios Alexandrakis
Guest Editor
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Keywords
- cellular or in vivo imaging of nanoparticle-guided cancer immunotherapy responses
- sorting or nano-sieving of ligands or receptors driving immune responses to cancer
- label-guided or label-free biomarker imaging of immunotherapy response
- ultra-sensitive nanosensing of immune-actionable cancer biomarkers in liquid samples
- new nanomaterials or nanoparticles to modulate the immune system's response to cancer
- cancer vaccines and new check-point inhibitor development and testing
- liposomes or other soft nanoparticles to modulate immune responses to cancer
- nanoparticle-mediated gene delivery or editing for immunotherapy
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