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Bioengineering
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Tissue Engineering for Regenerative Dentistry, 2nd Edition
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Tissue Engineering for Regenerative Dentistry, 2nd Edition

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1626

Special Issue Editor

Dr. Carlos Fernando Mourão

E-Mail Website
Guest Editor
Department of Basic and Clinical Translational Sciences, Tufts University School of Dental Medicine, Boston, MA 02111, USA
Interests: membranes/barriers; blood-derived growth factors; guide bone regeneration; soft tissue regeneration; biomaterials; regenerative medicine; drug delivery systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are excited to announce the launch of the Second Edition of the Special Issue “Tissue Engineering for Regenerative Dentistry”, which seeks to highlight cutting-edge advancements in integrating blood concentrates, stem cell therapies, and biomaterials for tissue regeneration purposes in dentistry.

The convergence of these regenerative strategies offers transformative potential for oral and maxillofacial rehabilitation. Autologous blood concentrates, which are rich in growth factors, cytokines, and leukocytes, have demonstrated a significant capacity to accelerate wound healing, stimulate angiogenesis, and promote soft and hard tissue regeneration. Concurrently, stem cells exhibit remarkable plasticity and regenerative power, activating endogenous repair pathways and contributing to tissue homeostasis.

Biomaterials, which include bioactive ceramics, biodegradable polymers, and composite scaffolds, act as vital frameworks that mimic the structure and biological signals of the natural extracellular matrix. These materials not only promote cellular adhesion and migration, but also enhance the processes of controlled differentiation and tissue integration.

This Special Issue aims to highlight the synergistic potential of these modalities, encouraging interdisciplinary research in the fields of bioengineering, biomaterials science, and clinical translation. By promoting a shift from conventional interventions to a biologically driven regenerative paradigm, we hope to contribute to a future where dental therapies are more predictable, personalized, and durable, ultimately enhancing patient outcomes and quality of life.

Dr. Carlos Fernando Mourão
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regenerative dentistry
  • autologous blood concentrates
  • platelet-rich fibrin (PRT)
  • stem cells
  • bioactive biomaterials
  • tissue engineering
  • oral and maxillofacial regeneration
  • extracellular matrix
  • translational research
  • dental tissue repair

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Related Special Issue

Published Papers (2 papers)

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21 pages, 929 KB  
Article
Applicability of Whole Blood Monocyte Activation Test for Endotoxin Activity Assessment in Hydroxyapatite-Based Ceramics
by Janaina Spoladore, Carolina Barbara Nogueira de Oliveira, Joice Correa da Silva, Elena Mavropoulos Tude, Carlos Fernando Mourão and Gutemberg Gomes Alves
Bioengineering 2026, 13(3), 319; https://doi.org/10.3390/bioengineering13030319 - 11 Mar 2026
Cited by 1 | Viewed by 399
Abstract
Hydroxyapatite-based ceramics are widely used in dental bioengineering, yet the reliable assessment of endotoxin activity in solid porous materials remains challenging. This study evaluated the applicability of a whole blood Monocyte Activation Test (MAT) to a hydroxyapatite ceramic relevant to dental applications. Two [...] Read more.
Hydroxyapatite-based ceramics are widely used in dental bioengineering, yet the reliable assessment of endotoxin activity in solid porous materials remains challenging. This study evaluated the applicability of a whole blood Monocyte Activation Test (MAT) to a hydroxyapatite ceramic relevant to dental applications. Two endotoxin association strategies (immersion and dropwise) were compared, followed by nonlinear modelling of cytokine dose–response curves using four-parameter logistic (4PL) regression and spike-recovery analysis to assess potential material interference. Immersion-based spiking produced reproducible, concentration-dependent cytokine responses, whereas dropwise application resulted in minimal functional recovery. IL-1β, IL-6, and TNF-α displayed sigmoidal dose–response profiles with high goodness-of-fit values (R2 ≥ 0.93). Spike recovery remained within the 50–200% acceptance range for most concentrations, with IL-6 showing the most consistent analytical performance. TNF-α exhibited signal saturation at higher endotoxin levels, limiting its dynamic range. Multiplex cytokine profiling confirmed that classical MAT readouts were among the most strongly induced mediators and that hydroxyapatite did not trigger baseline inflammatory activation. These findings demonstrate that whole blood MAT can be reliably applied to hydroxyapatite-based dental ceramics when immersion-based endotoxin association and material-specific methodological optimization are employed. Full article
(This article belongs to the Special Issue Tissue Engineering for Regenerative Dentistry, 2nd Edition)
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14 pages, 2886 KB  
Article
Covered Socket Residuum (CSR) in Former Third Molar Sockets Despite Platelet-Rich Fibrin: A Prospective Randomized Controlled Split-Mouth Clinical Study
by Shahram Ghanaati, Atoullo Kamolov, Jerry Bouquot, Robert Sader, Anja Heselich and Sarah Al-Maawi
Bioengineering 2025, 12(11), 1242; https://doi.org/10.3390/bioengineering12111242 - 12 Nov 2025
Cited by 1 | Viewed by 817
Abstract
Third molar extraction is a common oral surgical procedure that can be accompanied by challenges in wound healing and bone regeneration. Materials such as bone substitute materials (BSMs) and platelet-rich fibrin (PRF) are often used to support socket regeneration. This prospective randomized controlled [...] Read more.
Third molar extraction is a common oral surgical procedure that can be accompanied by challenges in wound healing and bone regeneration. Materials such as bone substitute materials (BSMs) and platelet-rich fibrin (PRF) are often used to support socket regeneration. This prospective randomized controlled split-mouth clinical trial compared PRF application combined with BSM versus PRF alone in patients requiring bilateral third molar extraction. A total of 15 patients underwent standardized osteotomy procedures, with sockets filled either with PRF alone (control group) or with BSM + PRF on opposite sides (test group) under general anesthesia and with patients blinded to the treatment allocation. Postoperative pain and swelling were measured over 7 days using a visual analog scale and anatomical distance measurements, respectively. Bone regeneration was evaluated using cone beam computed tomography (CBCT) scans after an average healing period of six months, with results showing no significant differences between groups in terms of postoperative pain or swelling (n = 12; 3 patients were lost to randomization). However, CBCT imaging revealed covered socket residuum (CSR)—non-mineralized areas within the socket—in the PRF only group, whereas the BSM + PRF group demonstrated more homogeneous and mineralized bone formation throughout the extraction sites (n = 8; 5 patients were lost to follow-up). These non-mineralized areas represent covered socket residuum within the extraction sockets, which poses a clinical risk of infection and may negatively affect the dental health of the adjacent second molar. Based on the presented findings, we recommend combining BSM with PRF to support bone regeneration and regulate the postoperative pain and swelling following third molar extraction. Nevertheless, further research is required to determine the most suitable BSM type in this regard. Full article
(This article belongs to the Special Issue Tissue Engineering for Regenerative Dentistry, 2nd Edition)
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