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Bioengineering
Special Issues
New Sights of Biomaterials and Regenerative Medicine
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New Sights of Biomaterials and Regenerative Medicine

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 3663

Special Issue Editor

Prof. Dr. Jinku Kim

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Guest Editor
Department of Biological and Chemical Engineering, Hongik University, Seoul, Republic of Korea
Interests: biomaterial; hydrogels; 3D bioprinting; tissue engineering/regenerative medicine

Special Issue Information

Dear Colleagues,

The aim of this special issue "New sights of biomaterials and regenerative medicine" is to provide a platform for researchers, scientists, and practitioners to showcase and discuss the latest developments, discoveries, and applications in the field of biomaterials and regenerative medicine.

The scope of this special issue encompasses a broad range of topics related to biomaterials and regenerative medicine, including but not limited to:

Biomaterials for tissue engineering: This includes the design, synthesis, and characterization of biomaterials used for the regeneration and repair of tissues and organs. This may involve the use of natural or synthetic materials, scaffolds, and matrices incorporating bioactive cues to promote tissue growth.

Stem cells and regenerative therapies: This involves investigating the potential of stem cells in regenerative medicine. This may include studies on the isolation, characterization, and differentiation of stem cells applicable to tissue regeneration, as well as the development of novel therapeutic approaches using stem cells.

Biofabrication and 3D printing: This includes the use of additive manufacturing techniques to create complex tissue scaffolds, implants, and organ constructs. This may involve the development of new biomaterial-based printing technologies, bioinks, and the integration of biomaterials and cells into functional tissue structures.

Drug delivery systems: This encompasses the design and development of biomaterial-based systems for controlled and targeted drug delivery. This may involve the encapsulation and release of therapeutic molecules, growth factors, or genetic materials to promote tissue regeneration and healing.

Prof. Dr. Jinku Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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21 pages, 8328 KiB  
Article
First Investigation of a Eustachian Tube Stent in Experimentally Induced Eustachian Tube Dysfunction
by Katharina Schmitt, Malena Timm, Philipp Krüger, Niels Oppel, Alexandra Napp, Friederike Pohl, Robert Schuon, Lisa Kötter, Marion Bankstahl, Thomas Lenarz, Tobias Stein and Gerrit Paasche
Bioengineering 2024, 11(10), 1015; https://doi.org/10.3390/bioengineering11101015 - 11 Oct 2024
Viewed by 951
Abstract
Unmet needs in the treatment of chronic otitis media and Eustachian tube dysfunction (ETD) triggered the development of stents for the Eustachian tube (ET). In this study, for the first time, stents were placed in an artificially blocked ET to evaluate stent function. [...] Read more.
Unmet needs in the treatment of chronic otitis media and Eustachian tube dysfunction (ETD) triggered the development of stents for the Eustachian tube (ET). In this study, for the first time, stents were placed in an artificially blocked ET to evaluate stent function. Eight adult female sheep were injected with stabilized hyaluronic acid (HA) on both sides to induce ETD. Subsequently, a tapered nitinol ET stent was inserted on one side, and animals were examined bilaterally by endoscopy, tympanometry, cone beam computed tomography, and final histology. Seven of the stents were placed in the desired cartilaginous portion of the ET. At the end of the study, one stented side appeared slightly open; all other ET orifices were closed. Tympanometry revealed re-ventilation of the middle ear in four out of seven correctly stented animals within 3 to 6 weeks after stent insertion. The major amount of HA was found at the pharyngeal orifice of the ET anterior to the stent. Thus, the stent position did not completely align with the HA position. While a functional analysis will require refinement of the experimental setup, this study provides first promising results for stent insertion in a sheep model of ETD. Full article
(This article belongs to the Special Issue New Sights of Biomaterials and Regenerative Medicine)
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25 pages, 5258 KiB  
Article
Long-Term Preclinical Evaluation of a Permanent Stent Developed for the Human Eustachian Tube
by Katharina Schmitt, Malena Timm, Philipp Krüger, Niels Oppel, Alexandra Napp, Friederike Pohl, Robert Schuon, Andreas Kampmann, Lisa Kötter, Marion Bankstahl, Thomas Lenarz, Tobias Stein and Gerrit Paasche
Bioengineering 2024, 11(8), 755; https://doi.org/10.3390/bioengineering11080755 - 25 Jul 2024
Cited by 1 | Viewed by 1284
Abstract
The Eustachian tube (ET) is a bottleneck when it comes to middle ear (ME) health. If its function is impaired, this can lead to serious consequences for the patient, such as hearing problems or deafness. Therefore, this study investigated a tapered nitinol stent [...] Read more.
The Eustachian tube (ET) is a bottleneck when it comes to middle ear (ME) health. If its function is impaired, this can lead to serious consequences for the patient, such as hearing problems or deafness. Therefore, this study investigated a tapered nitinol stent (3–5 mm × 14 mm) for the human ET as a potential new permanent treatment for chronic Eustachian tube dysfunction (ETD) and thus ME ventilation disorders. The self-expanding stent was inserted unilaterally into the ET of 24 sheep with observation periods of 3, 6, and 12 months. Local tissue effects and the safety of the stent insertion were analyzed based on regular endoscopic checks, weekly tympanometry measurements, final imaging, and histological examinations. The animals showed no stent-related health restrictions. However, the individual anatomy and stenting procedure had an influence on the results. The tissue reaction in the endoscopic examinations was mild even though no concomitant antibiotics were administered. After all three monitoring periods, stented ETs had a significantly larger ET lumen than the non-stented contralateral ETs. However, tissue growth was detected in the stent. Overall, the first long-term study on an ET stent showed that the tapered ET stent could be a promising treatment option for ETD. Full article
(This article belongs to the Special Issue New Sights of Biomaterials and Regenerative Medicine)
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Other

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16 pages, 5144 KiB  
Systematic Review
Progress in 3D Printing Applications for the Management of Orbital Disorders: A Systematic Review
by Luca Michelutti, Alessandro Tel, Massimo Robiony, Salvatore Sembronio, Riccardo Nocini, Edoardo Agosti, Tamara Ius, Caterina Gagliano and Marco Zeppieri
Bioengineering 2024, 11(12), 1238; https://doi.org/10.3390/bioengineering11121238 - 7 Dec 2024
Cited by 2 | Viewed by 1008
Abstract
Introduction: 3D printing technology has gained considerable interest in the domain of orbital illnesses owing to its capacity to transform diagnosis, surgery planning, and treatment. This systematic review seeks to deliver a thorough examination of the contemporary applications of 3D printing in [...] Read more.
Introduction: 3D printing technology has gained considerable interest in the domain of orbital illnesses owing to its capacity to transform diagnosis, surgery planning, and treatment. This systematic review seeks to deliver a thorough examination of the contemporary applications of 3D printing in the treatment of ocular problems, encompassing tumors, injuries, and congenital defects. This systematic review of recent studies has examined the application of patient-specific 3D-printed models for preoperative planning, personalized implants, and prosthetics. Methods: This systematic review was conducted according to the PRISMA guidelines. The PICOS is “What are the current advances and applications of 3D printing for the management of orbital pathology?” The databases analyzed for the research phase are MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, ScienceDirect, Scopus, CINAHL, and Web of Science. Results: Out of 314 studies found in the literature, only 12 met the inclusion and exclusion criteria. From the included studies, it is evident that 3D printing can be a useful technology for the management of trauma and oncological pathologies of the orbital region. Discussion: 3D printing proves to be very useful mainly for the purpose of improving the preoperative planning of a surgical procedure, allowing for better preparation by the surgical team and a reduction in operative time and complications. Conclusions: 3D printing has proven to be an outstanding tool in the management of orbit pathology. Comparing the advantages and disadvantages of such technology, the former far outweigh the latter. Full article
(This article belongs to the Special Issue New Sights of Biomaterials and Regenerative Medicine)
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