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Bioengineering
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Biomechanics and Biomaterials in Bone Tissue Engineering
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Biomechanics and Biomaterials in Bone Tissue Engineering

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomechanics and Sports Medicine".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 3954

Special Issue Editor

Prof. Dr. Dohyung Lim

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Sejong University, Seoul 05006, Republic of Korea
Interests: implant and scaffold design; biomaterials; total joint arthoplasty; orthopaedic biomechanics; bone morphology and mechanics; injury biomechanics; computer simulation; metallography; additive manufacturing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bone tissue engineering is a field in which it is important to study new approaches to promote the regeneration and repair of damaged or diseased bone. Biomechanics and biomaterials are important areas of study within bone tissue engineering.

Biomechanics in bone tissue engineering involve the study of mechanical behaviors and functions of new materials and implants intended for bone regeneration and repair. Understanding the biomechanics is critical for developing effective treatments for bone injuries and diseases.

Biomaterials in bone tissue engineering are materials used to replace or augment bone tissues injured and diseased, through the promotion of growth and regeneration of bone tissue. These materials must be biocompatible and able to withstand the mechanical stresses placed on them within the body.

Researchers in bone tissue engineering use a variety of biomaterials, including metals, ceramics, and polymers, to create scaffolds that can support the growth of new bone tissue. These scaffolds can be designed to promote the regeneration of bone damaged or lost.

In summary, the fields of biomechanics and biomaterials play important roles in bone tissue engineering by providing insights into the mechanical behaviors and functions of new materials and developing new materials for effective treatments for bone injuries and diseases.

This Special Issue of Materials, entitled “Biomechanics and Biomaterials in Bone Tissue Engineering”, will focus on recent progress in biomechanics and biomaterials in bone tissue engineering. Submitted manuscripts may cover all aspects related to biomechanics and biomaterials in bone tissue engineering.

It is my pleasure to invite you to submit a manuscript to this Special Issue. Full papers, communications, and reviews are all welcome.

Prof. Dr. Dohyung Lim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomechanics
  • biomaterials
  • bone tissue engineering
  • biological system
  • regeneration and repair
  • bone injury and damage

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Published Papers (3 papers)

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Research

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13 pages, 11334 KiB  
Article
Retrospective Study of Maxillary Sinus Augmentation Using Demineralized Tooth Block Bone for Dental Implant
by Hyunsuk Choi and Dong-Seok Sohn
Bioengineering 2024, 11(6), 633; https://doi.org/10.3390/bioengineering11060633 - 20 Jun 2024
Viewed by 595
Abstract
(1) Background: When placing implants in the maxillary posterior region with insufficient alveolar bone, a maxillary sinus elevation is necessary. Autogenous bone, though biologically ideal, poses risks and discomfort due to donor site harvesting. Block-type autogenous tooth bone graft material, made from the [...] Read more.
(1) Background: When placing implants in the maxillary posterior region with insufficient alveolar bone, a maxillary sinus elevation is necessary. Autogenous bone, though biologically ideal, poses risks and discomfort due to donor site harvesting. Block-type autogenous tooth bone graft material, made from the patient’s own extracted tooth, offers similar biological stability without these drawbacks. (2) Methods: This study observed the progress of 19 implant patients who were treated with maxillary sinus elevation procedures using block-type autogenous tooth bone graft material at the Daegu Catholic University Medical Center. Extracted teeth were processed into demineralized tooth block bone. After elevating the sinus membrane, implants and the tooth bone graft material were placed in the space, and the bony window was repositioned. Postoperative evaluations through clinical observation and radiographic imaging assessed sinus membrane elevation, alveolar bone height increase, and implant osseointegration. (3) Results: Results showed proportional increases in alveolar bone height to the graft material size, with long-term stability. No postoperative complications occurred, even with sinus membrane perforation, and implants remained stable. (4) Conclusions: The study concludes that maxillary sinus lifts using block-type autogenous tooth bone graft material provide excellent bone induction and biocompatibility, making this a highly beneficial method for both dentists and patients. Full article
(This article belongs to the Special Issue Biomechanics and Biomaterials in Bone Tissue Engineering)
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17 pages, 4264 KiB  
Article
Early Osteogenic-Induced Adipose-Derived Stem Cells and Canine Bone Regeneration Potential Analyzed Using Biodegradable Scaffolds
by Hyun-Ho Yun, Seong-Gon Kim, Se-Il Park, Woori Jo, Kyung-Ku Kang, Eun-Joo Lee, Dong-Kyu Kim, Hoe-Su Jung, Ji-Yoon Son, Jae-Min Park, Hyun-Sook Park, Sunray Lee, Hong-In Shin, Il-Hwa Hong and Kyu-Shik Jeong
Bioengineering 2023, 10(11), 1311; https://doi.org/10.3390/bioengineering10111311 - 13 Nov 2023
Cited by 1 | Viewed by 1339
Abstract
The complex process of bone regeneration is influenced by factors such as inflammatory responses, tissue interactions, and progenitor cells. Currently, multiple traumas can interfere with fracture healing, causing the prolonging or failure of healing. In these cases, bone grafting is the most effective [...] Read more.
The complex process of bone regeneration is influenced by factors such as inflammatory responses, tissue interactions, and progenitor cells. Currently, multiple traumas can interfere with fracture healing, causing the prolonging or failure of healing. In these cases, bone grafting is the most effective treatment. However, there are several drawbacks, such as morbidity at the donor site and availability of suitable materials. Advantages have been provided in this field by a variety of stem cell types. Adipose-derived stem cells (ASCs) show promise. In the radiological examination of this study, it was confirmed that the C/S group showed faster regeneration than the other groups, and Micro-CT also showed that the degree of bone formation in the defect area was highest in the C/S group. Compared to the control group, the change in cortical bone area in the defect area decreased in the sham group (0.874), while it slightly increased in the C/S group (1.027). An increase in relative vascularity indicates a decrease in overall bone density, but a weak depression filled with fibrous tissue was observed outside the compact bone. It was confirmed that newly formed cortical bone showed a slight difference in bone density compared to surrounding normal bone tissue due to increased distribution of cortical bone. In this study, we investigated the effect of bone regeneration by ADMSCs measured by radiation and pathological effects. These data can ultimately be applied to humans with important clinical applications in various bone diseases, regenerative, and early stages of formative differentiation. Full article
(This article belongs to the Special Issue Biomechanics and Biomaterials in Bone Tissue Engineering)
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Review

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18 pages, 1266 KiB  
Review
Metal Ion-Doped Hydroxyapatite-Based Materials for Bone Defect Restoration
by Xuan Wang, Shan Huang and Qian Peng
Bioengineering 2023, 10(12), 1367; https://doi.org/10.3390/bioengineering10121367 - 28 Nov 2023
Cited by 3 | Viewed by 1338
Abstract
Hydroxyapatite (HA)-based materials are widely used in the bone defect restoration field due to their stable physical properties, good biocompatibility, and bone induction potential. To further improve their performance with extra functions such as antibacterial activity, various kinds of metal ion-doped HA-based materials [...] Read more.
Hydroxyapatite (HA)-based materials are widely used in the bone defect restoration field due to their stable physical properties, good biocompatibility, and bone induction potential. To further improve their performance with extra functions such as antibacterial activity, various kinds of metal ion-doped HA-based materials have been proposed and synthesized. This paper offered a comprehensive review of metal ion-doped HA-based materials for bone defect restoration based on the introduction of the physicochemical characteristics of HA followed by the synthesis methods, properties, and applications of different kinds of metal ion (Ag+, Zn2+, Mg2+, Sr2+, Sm3+, and Ce3+)-doped HA-based materials. In addition, the underlying challenges for bone defect restoration using these materials and potential solutions were discussed. Full article
(This article belongs to the Special Issue Biomechanics and Biomaterials in Bone Tissue Engineering)
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