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Bioengineering
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New Treatments and Current Advances in Wound Healing: Cellular Mechanisms...
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New Treatments and Current Advances in Wound Healing: Cellular Mechanisms and Pathological Outcomes

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (15 May 2022) | Viewed by 12821

Special Issue Editors

Dr. Agata Janowska

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Guest Editor
Department of Dermatology, University of Pisa, 56126 Pisa, Italy
Interests: wound healing; atypical wounds; skin cancers
Special Issues, Collections and Topics in MDPI journals
Dr. Teresa Oranges

E-Mail Website
Guest Editor
Department of Dermatology, University of Pisa, Via Roma 67, 56126 Pisa, Italy
Interests: C-reactive protein; temperature; pH; SENSORS; biosensors; wound healing; chronic pruritus; itch; pruritus; wounds; itch in wounds; itch management
Prof. Dr. Chandan K. Sen

E-Mail Website
Guest Editor
PittMcGowan Wound Research Consortium, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Interests: biochemistry; genetics and molecular biology; tissue injury and repair

Special Issue Information

Dear Colleagues,

Chronic non-healing wounds are a major public health challenge. Chronic wounds are characterized by prolonged inflammation, defective re-epithelialization, and altered skin remodeling. Difficult-to-heal wounds persist in a self-perpetuating inflammatory state and remain unresponsive to adequate wound management. New therapies for chronic wounds have led to the improvement of lesion management and the quality of care. The study of wound healing pathophysiology and the development of new tools for precocious and effective intervention in the healing process may represent a useful strategy to optimize the efficacy of the treatment of these lesions. Thus, the aim of this Special Issue is to report new treatments and current advances in wound healing, considering cellular mechanisms and pathological outcomes. The scientific contributions on these topics may be submitted in the form of original articles or reviews. We look forward to receiving your manuscripts. Topics of interest for this Special Issue, entitled New Treatments and Current Advances in Wound Healing: Cellular Mechanisms and Pathological Outcomes, include, but are not limited to, the following: tissue engineering, drug delivery, photobiomodulation, new dressings, stem cell therapy and 3D printed skin.

Dr. Agata Janowska
Dr. Teresa Oranges
Prof. Dr. Chandan K Sen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • drug delivery
  • photobiomodulation
  • new dressings
  • stem cell therapy
  • 3D printed skin

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Published Papers (4 papers)

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Research

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14 pages, 12728 KiB  
Article
Solid PRF Serves as Basis for Guided Open Wound Healing of the Ridge after Tooth Extraction by Accelerating the Wound Healing Time Course—A Prospective Parallel Arm Randomized Controlled Single Blind Trial
by Shahram Ghanaati, Joanna Śmieszek-Wilczewska, Sarah Al-Maawi, Pauline Neff, Homayoun H. Zadeh, Robert Sader, Anja Heselich and James L. Rutkowski
Bioengineering 2022, 9(11), 661; https://doi.org/10.3390/bioengineering9110661 - 8 Nov 2022
Cited by 6 | Viewed by 3002
Abstract
Systematic evaluations regarding the influence of PRF in ridge sealing are still lacking. To the best of our knowledge, this is the first systemic randomized, controlled, clinical approach dealing with the potential of a systematic applied solid PRF on soft tissue socket healing [...] Read more.
Systematic evaluations regarding the influence of PRF in ridge sealing are still lacking. To the best of our knowledge, this is the first systemic randomized, controlled, clinical approach dealing with the potential of a systematic applied solid PRF on soft tissue socket healing of molar and premolar extraction sockets with evaluation for up to 90 days. Qualitative and quantitative image analysis showed that PRF contributed to a significantly faster ridge sealing, within the period of 7–10 days in both tooth types. This led to a visibly less contraction at the PRF-treated group sites at day 90. Patients’ pain perception demonstrated no statistic significance between both groups (PRF vs. natural healing), but the patients in PRF group seemed to have had less pain throughout the observational period. It becomes evident that PRF is able to serve as a promotor of the secondary wound healing cascade. The guiding capacity of PRF accelerating the process of open ridge healing makes it possible to act as a natural growth factor drug delivery system, providing a more predictable guided open wound healing of the ridge with less contraction of the soft tissue, the latter being a key factor for the subsequent successful dental implantation and oral rehabilitation. Full article
(This article belongs to the Special Issue New Treatments and Current Advances in Wound Healing: Cellular Mechanisms and Pathological Outcomes)
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22 pages, 132701 KiB  
Article
Bio-Mimicking Acellular Wet Electrospun Scaffolds Promote Accelerated Integration and Re-Epithelialization of Full-Thickness Dermal Wounds
by Jiah Shin Chin, Leigh E. Madden, Anthony R. J. Phillips, Sing Yian Chew and David L. Becker
Bioengineering 2022, 9(7), 324; https://doi.org/10.3390/bioengineering9070324 - 18 Jul 2022
Cited by 1 | Viewed by 2725
Abstract
Scaffolds can promote the healing of burns and chronic skin wounds but to date have suffered from issues with achieving full skin integration. Here, we characterise the wound response by both tissue integration and re-epithelialization to a scaffold using wet electrospinning to fabricate [...] Read more.
Scaffolds can promote the healing of burns and chronic skin wounds but to date have suffered from issues with achieving full skin integration. Here, we characterise the wound response by both tissue integration and re-epithelialization to a scaffold using wet electrospinning to fabricate 3D fibrous structures. Two scaffold materials were investigated: poly(ε-caprolactone) (PCL) and PCL + 20% rat tail type 1 collagen (PCL/Coll). We assessed re-epithelisation, inflammatory responses, angiogenesis and the formation of new extracellular matrix (ECM) within the scaffolds in rat acute wounds. The 3D PCL/Coll scaffolds impeded wound re-epithelisation, inducing a thickening of wound-edge epidermis as opposed to a thin tongue of migratory keratinocytes as seen when 3D PCL scaffolds were implanted in the wounds. A significant inflammatory response was observed with 3D PCL/Coll scaffolds but not with 3D PCL scaffolds. Enhanced fibroblast migration and angiogenesis into 3D PCL scaffolds was observed with a significant deposition of new ECM. We observed that this deposition of new ECM within the scaffold was key to enabling re-epithelialization over the scaffold. Such scaffolds provide a biocompatible environment for cell integration to lay down new ECM and encourage re-epithelisation over the implanted scaffold. Full article
(This article belongs to the Special Issue New Treatments and Current Advances in Wound Healing: Cellular Mechanisms and Pathological Outcomes)
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Review

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18 pages, 2803 KiB  
Review
Electrochemical Devices in Cutaneous Wound Healing
by J. Parker Evans and Chandan K. Sen
Bioengineering 2023, 10(6), 711; https://doi.org/10.3390/bioengineering10060711 - 11 Jun 2023
Cited by 9 | Viewed by 2853
Abstract
In healthy skin, vectorial ion transport gives rise to a transepithelial potential which directly impacts many physiological aspects of skin function. A wound is a physical defect that breaches the epithelial barrier and changes the electrochemical environment of skin. Electroceutical dressings are devices [...] Read more.
In healthy skin, vectorial ion transport gives rise to a transepithelial potential which directly impacts many physiological aspects of skin function. A wound is a physical defect that breaches the epithelial barrier and changes the electrochemical environment of skin. Electroceutical dressings are devices that manipulate the electrochemical environment, host as well as microbial, of a wound. In this review, electroceuticals are organized into three mechanistic classes: ionic, wireless, and battery powered. All three classes of electroceutical dressing show encouraging effects on infection management and wound healing with evidence of favorable impact on keratinocyte migration and disruption of wound biofilm infection. This foundation sets the stage for further mechanistic as well as interventional studies. Successful conduct of such studies will determine the best dosage, timing, and class of stimulus necessary to maximize therapeutic efficacy. Full article
(This article belongs to the Special Issue New Treatments and Current Advances in Wound Healing: Cellular Mechanisms and Pathological Outcomes)
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14 pages, 1134 KiB  
Review
Physical Stimulation Combined with Biomaterials Promotes Peripheral Nerve Injury Repair
by Zhipeng Zeng, Yajing Yang, Junyong Deng, Muhammad Saif Ur Rahman, Chengmei Sun and Shanshan Xu
Bioengineering 2022, 9(7), 292; https://doi.org/10.3390/bioengineering9070292 - 30 Jun 2022
Cited by 10 | Viewed by 3450
Abstract
Peripheral nerve injury (PNI) is a clinical problem with high morbidity that can cause severe damage. Surgical suturing or implants are usually required due to the slow speed and numerous factors affecting repair after PNI. An autologous nerve graft is the gold standard [...] Read more.
Peripheral nerve injury (PNI) is a clinical problem with high morbidity that can cause severe damage. Surgical suturing or implants are usually required due to the slow speed and numerous factors affecting repair after PNI. An autologous nerve graft is the gold standard for PNI repair among implants. However, there is a potential problem of the functional loss of the donor site. Therefore, tissue-engineered nerve biomaterials are often used to bridge the gap between nerve defects, but the therapeutic effect is insufficient. In order to enhance the repair effect of nerve biomaterials for PNI, researchers are seeking to combine various stimulation elements, such as the addition of biological factors such as nerve growth factors or physical factors such as internal microstructural modifications of catheters and their combined application with physical stimulation therapy. Physical stimulation therapy is safer, is more convenient, and has more practical features than other additive factors. Its feasibility and convenience, when combined with nerve biomaterials, provide broader application prospects for PNI repair, and has therefore become a research hot spot. This paper will review the combined application of physical stimulation and biomaterials in PNI repair in recent years to provide new therapeutic ideas for the future use of physical stimulation in PNI repair. Full article
(This article belongs to the Special Issue New Treatments and Current Advances in Wound Healing: Cellular Mechanisms and Pathological Outcomes)
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