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Bioengineering
Special Issues
Bioengineering Strategies for Cardiac Tissue
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Bioengineering Strategies for Cardiac Tissue

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 1063

Special Issue Editor

Dr. Mohamed Ghorbel

E-Mail Website
Guest Editor
Bristol Heart Institute, Bristol Medical School, University of Bristol, Bristol BS2 8HW, UK
Interests: congenital heart disease; translational cardiovascular medicine; tissue engineering; stem cells; cell therapy; vascular grafts; cardiac patches; angiogenesis; tissue decellularization; 3D bioprinting; ATMPs; large animal models

Special Issue Information

Dear Colleagues,

Cardiovascular disease is a major cause of death and morbidity globally. Bioengineering living cardiovascular tissue promises to help in treating some of these diseases like Congenital Heart Defects (CHDs). Indeed, a major problem with corrective surgery for such CHDs is the lack of living replacement materials with the capacity of growth and regeneration. Many children need prosthetic replacement grafts in the form of new valves, conduits, and patches. Although these grafts may be lifesaving, they have limited durability and CHD patients often require repeat operations in the future as these replacement grafts do not grow. Additionally, bioengineering living cardiovascular tissue offers a tool for studying the pathology and therapy of cardiovascular diseases.

This Special Issue of Bioengineering will focus on the bioengineering strategies for cardiovascular tissue and aims to showcase high-quality contributions addressing current challenges in this field. Topics of interest include but are not limited to stem cell research; cardiovascular tissue engineering; scaffolds and biomaterials; tissue decellularization and cell seeding; cell differentiation; 3D cell culture; 3D bioprinting; bioreactors; tissue-engineered vessels; tissue-engineered cardiac patches; cardiovascular disease modeling; and translational cardiovascular medicine.

Dr. Mohamed Ghorbel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • congenital heart disease
  • cardiovascular disease modeling
  • corrective heart surgery
  • bioengineering
  • cardiovascular tissue
  • stem cells
  • vascular grafts
  • cardiac patches
  • 3D bioprinting
  • biomaterials

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Published Papers (1 paper)

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16 pages, 4402 KiB  
Article
Computational Model for Early-Stage Aortic Valve Calcification Shows Hemodynamic Biomarkers
by Asad Mirza, Chia-Pei Denise Hsu, Andres Rodriguez, Paulina Alvarez, Lihua Lou, Matty Sey, Arvind Agarwal, Sharan Ramaswamy and Joshua Hutcheson
Bioengineering 2024, 11(10), 955; https://doi.org/10.3390/bioengineering11100955 - 24 Sep 2024
Viewed by 861
Abstract
Heart disease is a leading cause of mortality, with calcific aortic valve disease (CAVD) being the most prevalent subset. Being able to predict this disease in its early stages is important for monitoring patients before they need aortic valve replacement surgery. Thus, this [...] Read more.
Heart disease is a leading cause of mortality, with calcific aortic valve disease (CAVD) being the most prevalent subset. Being able to predict this disease in its early stages is important for monitoring patients before they need aortic valve replacement surgery. Thus, this study explored hydrodynamic, mechanical, and hemodynamic differences in healthy and very mildly calcified porcine small intestinal submucosa (PSIS) bioscaffold valves to determine any notable parameters between groups that could, possibly, be used for disease tracking purposes. Three valve groups were tested: raw PSIS as a control and two calcified groups that were seeded with human valvular interstitial and endothelial cells (VICs/VECs) and cultivated in calcifying media. These two calcified groups were cultured in either static or bioreactor-induced oscillatory flow conditions. Hydrodynamic assessments showed metrics were below thresholds associated for even mild calcification. Young’s modulus, however, was significantly higher in calcified valves when compared to raw PSIS, indicating the morphological changes to the tissue structure. Fluid–structure interaction (FSI) simulations agreed well with hydrodynamic results and, most notably, showed a significant increase in time-averaged wall shear stress (TAWSS) between raw and calcified groups. We conclude that tracking hemodynamics may be a viable biomarker for early-stage CAVD tracking. Full article
(This article belongs to the Special Issue Bioengineering Strategies for Cardiac Tissue)
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