Cognitive Decline and Its Transversality: Potential Mechanisms and Modulators of Disease
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 65
Special Issue Editors
Interests: cognitive impairment; dementia; cognitive functions; genetics and epigenetics
Special Issues, Collections and Topics in MDPI journals
Interests: multiple sclerosis; biomarkers; DMTs; progression; cognitive impairment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cognitive decline represents, in all its clinical manifestations, a challenge in the field of research and a problem for global public health. It can be an expression of neurodegenerative dementing pathologies or contextualized in other pathologies (e.g., multiple sclerosis, cerebrovascular pathologies, infectious, toxic metabolic diseases, etc.). The mechanisms of disease in cognitive impairment are numerous and different depending on the pathologies that underlie it. Among the numerous mechanisms are protein misfolding in forms of neurodegenerative dementia (Alzheimer's disease, frontotemporal lobar degeneration, and Lewy body dementia), neurodegenerative and neuroinflammatory processes (multiple sclerosis), glial cell involvement, and vascular and metabolic involvement (heart–brain axis, gut–brain axis, diabetes, etc.). On the other hand, among the possible modulators, we think of epigenomics, transcriptomics, and therefore micro-RNAs and long non-coding RNAs. Therefore, the primary targets in the face of a decline in cognitive function are:
- Identify the underlying cause through both preclinical (cellular or animal models) and clinical (morphological and functional neuroimaging studies) studies;
- Detect it early through the use of biomarkers;
- Identify modulators of the disease course that could be potential therapeutic targets.
Dr. Cinzia Coppola
Dr. Elisabetta Signoriello
Guest Editors
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Keywords
- cognitive decline
- Alzheimer’s disease
- fronto-temporal lobar degeneration
- Lewy body disease
- multiple sclerosis
- protein misfolding
- amyloid
- tauopathy
- neuroinflammation
- microglia
- astroglia
- synaptopathy
- CSF biomarkers
- plasmatic biomarkers
- micro-RNA or miRNA
- long noncoding RNA or lncRNA
- heart–brain axis
- gut–brain axis
- cerebrovascular disease
- hippocampal atrophy
- structural and functional neuroimaging
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