Advanced Therapeutic Approaches for Musculoskeletal Tissue Regeneration
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 8524
Special Issue Editor
Interests: design and fabricate biomimetic polymer systems for tissue regeneration and drug delivery applications, particularly focusing on orthobiologics, customized scaffolds, injectable hydrogels, and controlled release
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The overall goal of this Special Issue is to present a broad review of recent advances in developing novel therapeutic approaches for musculoskeletal tissue regeneration, especially under challenging disease conditions such as chronic osteoporotic disorders. The human musculoskeletal system offers structural and mechanical support to our body and protects the delicate internal organs. Musculoskeletal disorders are increasingly prevalent, particularly in the aging population, posing significant health issues with increasing medical and socioeconomic burdens. Notably, the prevalence of age-related chronic degenerative diseases leads to extreme clinical challenges in the treatment of musculoskeletal injury. Although the conventional therapeutic modalities including auto/allografts have been conducted in musculoskeletal tissue regeneration, they are significantly restricted by availability, disease transmission and reproducibility. Tissue engineering involved in stem cells, growth factors and biomaterials represents a promising strategy to restore musculoskeletal tissue structures and functions. In the past few decades, the tissue engineering-based approach has evolved rapidly due to significant advances in the underlying mechanisms of stem cell and tissue development, biomaterial fabrication, animal disease models and multidisciplinary integration.
This Special Issue on “Advanced Therapeutic Approaches for Musculoskeletal Tissue Regeneration” is open for original papers and reviews that are dedicated to the development of novel therapeutic approaches for musculoskeletal tissue repair and regeneration.
The topics and themes of this unique collection will include, but are not limited to, the following:
- Novel molecular mechanism studies on the lineage commitment of mesenchymal stem cells;
- The creation of novel biomaterials for cell, gene/drug and growth factor carriers;
- Novel animal disease models created for the efficient evaluation of pre-clinical treatment;
- Advanced application of mesenchymal stem cell (MSC)-mediated treatment;
- The application of a cell-free approach such as MSC-derived exosomes for musculoskeletal tissue regeneration;
- New therapeutic strategies developed for tissue regeneration under chronic degenerative disease conditions;
- Developing a translational therapeutic approach for potential clinical application.
Dr. Jiabing Fan
Guest Editor
Manuscript Submission Information
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Keywords
- stem cells
- exosomes
- growth factor
- biomaterials
- drug/gene delivery
- molecular therapy
- gene therapy
- tissue engineering
- animal disease models
- clinical application
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