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Bioengineering publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bioinformatics for Cardiovascular Disease

edited by João P. Monteiro and Quanyi Zhao

submission deadline 28 Feb 2026 | Viewed by 65 | Submission Open

Keywords: bioinformatics; cardiovascular disease; single-cell RNA-seq; single-cell ATAC-seq; spatial profiling; genomics; machine learning; multi-omics integration; systems biology; cardiac modeling; precision medicine; big data; translational bioinformatics

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

From 3D/4D Printing to Biofunctional Surfaces and Smart Implant Systems

edited by

Yuhe Yang

submission deadline 28 Feb 2026 | Viewed by 61 | Submission Open

Keywords: 3D/4D printing; biofunctional surfaces; smart implants; additive manufacturing in biomedicine

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Engineering with Nature: Bioengineering Innovations for the Environment and Nature-Based Solutions

edited by

Kristian L. Dubrawski

submission deadline 28 Feb 2026 | Viewed by 61 | Submission Open

Keywords: nature-based solutions; bioengineering; environmental sustainability; bioremediation; ecological engineering

(This special issue belongs to the Section Biochemical Engineering)

Advances in Novel Remineralizing Materials: Innovations for Sustainable Oral and Biomedical Applications

edited by Robert Hill

submission deadline 28 Feb 2026 | Viewed by 53 | Submission Open

Keywords: dental materials; remineralization; bioactive glass; glass ionomer cements; calcium phosphate cements; nanotechnology; adhesion; sustainable dentistry; clinical performance; biomedical engineering

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Polymeric Biomaterials for Drug Delivery

edited by

Pere Dosta Pons

submission deadline 28 Feb 2026 | Viewed by 52 | Submission Open

Keywords: biomaterials; polymeric nanoparticles; stimuli-responsive systems; biodegradable polymers; drug delivery; gene therapy; targeted delivery; controlled release

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Advanced Cryopreservation and Innovative Rewarming Strategies for Cells, Tissues, Organs and Organisms

edited by

Ramon Risco

and

Estefanía Paredes

submission deadline 10 Mar 2026 | Viewed by 110 | Submission Open

Keywords: cryopreservation; vitrification strategies; rewarming technologies; cryoprotective agents; fertility preservation; plant cryobiology; aquatic species conservation; astrobiology and extreme environments

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

Machine Learning in Ultrasound Imaging

edited by Laura Brattain, Vivek Singh and Md Mostafa Kamal Sarker

submission deadline 15 Mar 2026 | Viewed by 165 | Submission Open

Keywords: computer-aided diagnosis; medical image analysis; image segmentation; procedural guidance; clinical decision support; elastography; contrast-enhanced ultrasound; point-of-care ultrasound (POCUS); multimodal imaging

(This special issue belongs to the Section Biosignal Processing)

MRI and Its Applications

edited by

Dongrong Xu

Ravi Bansal

and

Zhiyong Zhao

submission deadline 20 Mar 2026 | Viewed by 116 | Submission Open

Keywords: MRI; multiparametric MRI; cancer Imaging; tumor characterization; therapy monitoring; whole-body MRI; pediatric MRI; oncologic imaging; clinical MRI

(This special issue belongs to the Section Biosignal Processing)

Bioengineering Strategies for Ophthalmic Diseases

edited by

Jae Yong Kim

submission deadline 31 Mar 2026 | 3 articles | Viewed by 7097 | Submission Open

Keywords: ophthalmic diseases; imaging technology; artificial intelligence; retinal regeneration; corneal implants; drug delivery

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Applications of Computational Modeling in Biomedical Image and Signal Processing—2nd Edition

edited by Xuxin Chen and

Bin Zheng

submission deadline 31 Mar 2026 | 3 articles | Viewed by 6337 | Submission Open

Keywords: computational modeling; quantitative disease markers; medical image processing; image segmentation; biosignal testing; biosignal processes; feature selection; deep learning; computer-aided diagnosis; data standardization; synthetic data generation

(This special issue belongs to the Section Biosignal Processing)

Development of Bioelectrochemical Systems for Environmental Engineering

edited by

Shiue-Lin Li

submission deadline 31 Mar 2026 | 3 articles | Viewed by 6087 | Submission Open

Keywords: bioelectrochemical systems; microbial fuel cells; bioelectrosynthesis; high-added value chemicals; environmental engineering

(This special issue belongs to the Section Biochemical Engineering)

Innovative Approaches: Harnessing Virtual Reality for Assessment and Rehabilitation in Stroke and Aging-Related Disorders

edited by Gauthier Everard and

Charles Sebiyo Batcho

submission deadline 31 Mar 2026 | 4 articles | Viewed by 4887 | Submission Open

Keywords: virtual reality; assessment; rehabilitation; stroke; neurorehabilitation; older adults; kinematics; cognition

(This special issue belongs to the Section Biosignal Processing)

Recent Advances in Genomics Research

edited by Chien-Wei (Masaki) Lin

submission deadline 31 Mar 2026 | 3 articles | Viewed by 4114 | Submission Open

Keywords: genomics data analysis; NGS; AI; machine learning; multi-omics integration; single-cell sequencing; precision medicine

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

Biomaterials for the Repair and Regeneration of Musculoskeletal Tissue

edited by Christopher Bibbo

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3732 | Submission Open

Keywords: musculoskeletal; soft tissue; bone; cartilage; nerve; regenerative medicine; reconstructive surgery

(This special issue belongs to the Section Regenerative Engineering)

Wearable, Flexible, and Integrated Microfluidic-Based Biosensors for Point-of-Care Testing Applications

edited by Madhusudan B. Kulkarni

submission deadline 31 Mar 2026 | 1 articles | Viewed by 3378 | Submission Open

Keywords: biomedical electronic devices; health-monitoring wearables; implantable sensors; bioelectronic medicine; personalized healthcare

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Novel Imaging Techniques in Radiotherapy

edited by

Zijian Deng

and Junwei Shi

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3134 | Submission Open

Keywords: radiotherapy; imaging; tumor localization; treatment assessment; radiation toxicity

(This special issue belongs to the Section Biosignal Processing)

Augmented Reality, Virtual Reality and Extended Reality Solutions for Biomedical Applications

edited by

Vera Gramigna

and Arrigo Palumbo

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3055 | Submission Open

Keywords: augmented reality (AR); virtual reality (VR); extended reality (XR); biomedicine; human– robot interaction; technology in healthcare; medical imaging; surgical simulation; surgical navigation; robotic-assisted surgery; rehabilitation technology; neurological disorders’ treatment; pain management; personalized healthcare; artificial intelligence (AI) in medicine; human– computer interaction in healthcare; digital health technologies

(This special issue belongs to the Section Biosignal Processing)

Microalgae Biotechnology and Microbiology: Prospects and Applications

edited by Dora Allegra Carbone and Michael Melkonian

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3050 | Submission Open

Keywords: microalgae; bacteria; photobioreactor; bioengineering; biomass; wastewater; compounds

(This special issue belongs to the Section Biochemical Engineering)

Challenges for Managing Glaucoma in the 21st Century

edited by

Karanjit S. Kooner

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2449 | Submission Open

Keywords: retinal imaging; artificial intelligence; minimally invasive glaucoma surgeries (MIGSs); telemedicine; neuroimaging

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Cardiovascular Models and Biomechanics

edited by

Hwa Liang Leo

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1616 | Submission Open

Keywords: vascular mechanics; patient-specific modeling; cardiovascular devices; mechanobiology; experimental methods; computational modeling; machine learning

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Artificial Intelligence and Wearable Biosensors for Precision Medicine: Integrating Technology

edited by

Matteo Frigerio

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1343 | Submission Open

Keywords: healthcare; gynecology; pelvic floor medicine; pelvic floor rehabilitation; pelvic floor training; laparoscopy; pelvic organ prolapse; urinary incontinence; anal incontinence; overactive bladder; ultrasound; urodynamics; urogynecology; new technologies; pelvic pain; laser; radiofrequency; magnetic stimulation; functional electrical stimulation; biofeedback; vaginal rejuvenation; electronic bladder diaries; sacral neuromodulation; women’ s health

(This special issue belongs to the Section Biosignal Processing)

Bioengineering and the Eye—3rd Edition

edited by

Dimitrios Karamichos

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1160 | Submission Open

Keywords: stem cell therapies; functional ocular tissue equivalents; biomaterials; 3D bioprinting; tissue engineering

(This special issue belongs to the Section Regenerative Engineering)

Contribution of Bioprocess Engineering to the Achievement of the UN Sustainable Development Goals (SDGs)

edited by

Dirk Holtmann

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1136 | Submission Open

Keywords: bioprocess engineering; sustainability; sustainable development goals (SDGs)

(This special issue belongs to the Section Biochemical Engineering)

Contemporary Trends and Future Perspectives in Orthodontic Treatment

edited by

Simone Parrini

and

Gabriele Rossini

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1126 | Submission Open

Keywords: orthodontic biomechanics; clear aligners; digital orthodontics; artificial intelligence; finite element analysis; interdisciplinary treatment; patient experience; long-term stability; innovative appliances; future trends in orthodontics

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Recent Advances in Soft Tissue Characterization Using Optical Techniques

edited by Bin Yang,

John Viator

and Xu Feng

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1115 | Submission Open

Keywords: optical elastography; spectroscopy; optical imaging; disease diagnostics; tissue optics; artificial intelligence

(This special issue belongs to the Section Biosignal Processing)

Nanobiosensors for Age-Related Diseases Diagnosis

edited by

Chaker Tlili

and

Mohamed Amin Elaguech

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1023 | Submission Open

Keywords: nanobiosensors; nanomaterials; age-related diseases; wearable devices; implantable devices

(This special issue belongs to the Section Biosignal Processing)

Advances and Clinical Applications of Anterior Segment Imaging Techniques—2nd Edition

edited by

Sang Beom Han

submission deadline 31 Mar 2026 | 1 articles | Viewed by 959 | Submission Open

Keywords: anterior segment; cornea; cataract; conjunctiva; anterior segment imaging; refractive surgery

AI-Driven Advances in Biomedical Diagnosis and Prognosis: Innovations, Applications, and Emerging Trends

edited by

Rizwan Ali Naqvi

, Fayaz A. Ali Dharejo and

Kiran Zahra

submission deadline 31 Mar 2026 | Viewed by 864 | Submission Open

Keywords: artificial intelligence; deep learning; biomedical imaging; biomedical sensing; disease diagnosis; disease prognosis; treatment monitoring; clinical decision-making

(This special issue belongs to the Section Biosignal Processing)

Applications of Artificial Intelligence for Medical Diagnosis

edited by Alessio Luschi and Pietro Rubegni

submission deadline 31 Mar 2026 | 1 articles | Viewed by 819 | Submission Open

Keywords: healthcare; medicine; artificial intelligence; deep learning; machine learning; generative AI

(This special issue belongs to the Section Biosignal Processing)

Advanced Dental Materials for Restorative Dentistry

edited by

Feng Gao

submission deadline 31 Mar 2026 | 1 articles | Viewed by 804 | Submission Open

Keywords: denal restoration; restorative dentistry; dental biomaterials

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

AI Advancements in Healthcare: Medical Imaging and Sensing Technologies, 2nd Edition

edited by

Mohammed A. Al-masni

and Kanghyun Ryu

submission deadline 31 Mar 2026 | 1 articles | Viewed by 636 | Submission Open

Keywords: biomedical imaging; biosignals; medical image analysis; abnormalities classification and detection; medical image segmentation; medical image reconstruction; medical image denoising; medical image registration; AI in biomedical systems; computer-aided diagnosis systems

(This special issue belongs to the Section Biosignal Processing)

Artificial Intelligence and Nanotechnology in Cancer Therapy

edited by Wancheng Guo and

Aarti Sharma

submission deadline 31 Mar 2026 | Viewed by 630 | Submission Open

Keywords: AI; nanotechnology; cancer therapy

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Bioengineering Cardiovascular Cell and Gene Therapies: Advances and Translational Challenges

edited by

Emre Bektik

and

Kurt Pfannkuche

submission deadline 31 Mar 2026 | Viewed by 434 | Submission Open

Keywords: myocardial infarction; atherosclerosis; peripheral artery disease (PAD); stem cells differentiation; iPSCs disease modeling; biomaterials; gene delivery; tissue engineering approaches; vascular regeneration; cardiac repair; CRISPR gene editing; bio-scaffolds; bioprinting; microfluidics; organ-on-a-chip; immunomodulation; exosomes; drug delivery; clinical translation

(This special issue belongs to the Section Regenerative Engineering)

Technological Advances in Neurorehabilitation

edited by

Susan Duff

and Andria J. Farrens

submission deadline 31 Mar 2026 | Viewed by 344 | Submission Open

Keywords: assistive technology; neuroimaging; neurorehabilitation; robotics; wearables

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Computational Intelligence for Healthcare

edited by

Jiaojiao Wang

, Chee Wei Tan and Qingpeng Zhang

submission deadline 31 Mar 2026 | Viewed by 340 | Submission Open

Keywords: artificial intelligence; big data analytics; generative models; pathogen tracking and tracing; chronic disease prediction and management; predictive modeling; bioinformatics; pandemic preparedness; IoT-enabled biosensors; health disparities and ethics; multi-modal data fusion

(This special issue belongs to the Section Biosignal Processing)

Multiscale Modeling in Computational Biomechanics: When Contemporary AI Meets Virtual Human Twin

edited by

Tien Tuan Dao

submission deadline 31 Mar 2026 | Viewed by 318 | Submission Open

Keywords: multiscale modeling; computational biomechanics; AI-driven biomechanics; virtual human twin; generative AI in medicine

(This special issue belongs to the Section Biomechanics and Sports Medicine)

Hot Melt Extrusion and 3D Printing for Enhanced Drug Delivery

edited by

Sateesh Kumar Vemula

submission deadline 31 Mar 2026 | Viewed by 273 | Submission Open

Keywords: 3D printing in pharmaceutics; additive manufacturing in pharmaceuticals; biodegradable polymers; controlled drug release; devices for drug delivery; hot-melt extrusion (HME); implantable drug delivery systems; personalized medicine; regulatory aspects of 3D-printed dosage forms; solid dispersions

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Strategies for Microbial Bioprocess Optimization

edited by

Razieh Rafieenia

submission deadline 31 Mar 2026 | Viewed by 264 | Submission Open

Keywords: metabolic engineering; fermentation; synthetic biology; bioreactor design; synthetic microbial communities; machine learning based process design; renewable substrates; life cycle assessment

(This special issue belongs to the Section Biochemical Engineering)

Machine Learning and Artificial Intelligence for Biostatistics

edited by Muktar Beshir Ahmed and

Mehdi Neshat

submission deadline 31 Mar 2026 | Viewed by 230 | Submission Open

Keywords: artificial intelligence; machine learning; biostatistics; medical image analysis; biosignal processing; bioinformatics; deep learning; biomedical data science; clinical prediction; statistical learning

(This special issue belongs to the Section Biosignal Processing)

Bio-Applications of Engineered Escherichia coli—Second Volume

edited by

Joana Rodrigues

and

Debora Ferreira

submission deadline 31 Mar 2026 | Viewed by 224 | Submission Open

Keywords: Escherichia coli; heterologous production; biosynthetic pathways; value-added compounds; microbial chassis; microbial host; biosensors; whole-cell biosensors; diagnosis tools; therapeutic tools

(This special issue belongs to the Section Biochemical Engineering)

Advanced Bioprocessing Approaches in Energy and Nutrient Recovery from Waste

edited by

Rajinikanth Rajagopal

and

Chunjiang An

submission deadline 31 Mar 2026 | Viewed by 183 | Submission Open

Keywords: anaerobic digestion; biogas production; biogas upgrading; hydrothermal carbonization; thermochemical processes; microbial communities; manure management; wastewater treatment; nutrient recovery; energy recovery; computational modeling; machine learning; circular economy; methane yield; nitrogen recovery; phosphorus recovery

(This special issue belongs to the Section Biochemical Engineering)

Biomaterial- and Engineering-Based Approaches for Organoids

edited by Xiuzhi Susan Sun

submission deadline 31 Mar 2026 | Viewed by 169 | Submission Open

Keywords: organoids; biomaterials; tissue engineering; three-dimensional bioprinting; microfluidics; extracellular matrix; disease modeling; regenerative medicine; personalized medicine

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Stem Cell Immunoengineering

edited by Yun Chang

submission deadline 31 Mar 2026 | Viewed by 162 | Submission Open

Keywords: stem cell; immunoengineering; immune cells; genetic and epigenetic programming; biomaterials; delivery system

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Preclinical Models in Cardiovascular Disease Research

edited by

Muhammad Riaz

submission deadline 31 Mar 2026 | Viewed by 114 | Submission Open

Keywords: cardiovascular diseases; preclinical cell models; preclinical animal models; iPSCs; organ-on-chip; computational models

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

AI in Biomedical Image Segmentation, Processing and Analysis

edited by

Toufique Ahmed Soomro

Lihong Zheng

and Mohammad Ali Moni

submission deadline 31 Mar 2026 | Viewed by 113 | Submission Open

Keywords: artificial intelligence; biomedical imaging; image segmentation; deep learning; medical image processing; radiomics; explainable AI; computer-aided diagnosis

(This special issue belongs to the Section Biosignal Processing)

Gene Therapies for Regenerative Medicine

edited by

Eddie Han Pin Tan

and

Yie Hou Lee

submission deadline 31 Mar 2026 | Viewed by 74 | Submission Open

Keywords: cell therapy; gene therapy; regenerative medicine; gene delivery; stem cell engineering; tissue engineering; biomaterials; cell reprogramming; viral vectors

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

Biomedical Engineering Strategies for Scoliosis Treatment

edited by Pier Francesco Costici and Sergio De Salvatore

submission deadline 31 Mar 2026 | Viewed by 66 | Submission Open

Keywords: scoliosis; AIS; gait analysis; posture analysis; spine surgery

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Diagnostic Biomedical Image and Processing with Artificial Intelligence and Deep Learning—2nd Edition

edited by

Hongying Meng

and Xinrong Chen

submission deadline 31 Mar 2026 | Viewed by 61 | Submission Open

Keywords: biomedical image; artificial intelligence; deep learning; image processing; medical imaging; computer-assisted diagnosis; pattern recognition; computer vision; bioengineering; medical large language models

(This special issue belongs to the Section Biosignal Processing)

Electromechanical Effects in Biomedical Science: Mechanisms, Materials, and Medical Applications

edited by

Melika Mohammadkhah

Dragan Marinkovic

and

Paula Pascoal-Faria

submission deadline 31 Mar 2026 | Viewed by 55 | Submission Open

Keywords: electromechanical effects; piezoelectricity; flexoelectricity; bone remodeling and regeneration; mechanobiology; regenerative medicine; smart biomaterials; tissue engineering; biomedical applications; electroactive scaffold; computational modeling of coupled effects; experimental identification of electromechanical effects in tissues; smart drug delivery systems; bioelectronic medicine; smart medical technology; digital twin models for tissue engineering applications

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Advances in Tissue Engineering and Next-Generation Biomaterials: From Techniques to Emerging Applications

edited by