Biological Advances in Pluripotent Stem Cells
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cell Biology".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 20
Special Issue Editors
Interests: ubiquitin; ubiquitin-E3-Ligase; TRIM-family; deubiquitinase; OTUD-family; transcription factors; stem cells; neurogenesis; eye development; Xenopus
Special Issue Information
Dear Colleagues,
In 2007, the groundbreaking discovery that terminally differentiated human cells can be reprogrammed to a stem cell-like state opened enormous hopes for regenerative medicine and drug research. These so-called induced pluripotent stem cells (iPSCs) grow in petri dishes, and soon protocols were available, which allowed us to generate specifically almost every cell type of the human body. Moreover, iPSCs circumvented the need to generate embryonic stem cells, where the inner cell mass or cells of preimplantation embryos are employed, which raised a strong controversial discussion. With iPSCs, researchers become able to generate autologous replacement tissue easily on the first look, tissue appropriate for transplantation to treat various pathologic conditions since the donor and recipient are the same. Did the great hopes have become true until today? However, more than 20 clinical trials, not counting industrial trials, are currently underway for therapeutic interventions. Most of them are still in the early stages, with the primary aim of confirming safety rather than efficacy. However, there are also studies that are promising. For example, patients suffering from corneal epithelial cell exhaustion syndrome recovered their vision immediately after the transplantation of a corneal sheath obtained from iPSCs. In this Special Issue, we aim to discuss new directions of iPSC applications in translational biology as well as new aspects of iPSCs in basic research.
Prof. Dr. Thomas Hollemann
Dr. Matthias Jung
Guest Editors
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Keywords
- induced pluripotent stem cell
- embryonic stem cell
- regenerative medicine
- drug research
- organoid
- translational biology
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