DNA Repair and DNA Damage Response (DDR) in Oncology
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 40
Special Issue Editor
Special Issue Information
Dear Colleagues,
DNA repair and DNA damage response (DDR) are crucial for maintaining genomic stability, and their dysregulation plays a key role in cancer initiation, progression, and therapeutic resistance. This Special Issue explores the molecular mechanisms of DDR pathways, including homologous recombination, non-homologous end-joining, base excision repair, and mismatch repair, in the context of oncology. We aim to highlight emerging therapeutic strategies targeting DDR deficiencies, such as PARP inhibitors and synthetic lethality approaches, as well as the role of DDR biomarkers in personalized cancer treatment. Contributions covering fundamental research, translational studies, and clinical applications of DDR-targeted therapies are welcome. This Special Issue aims to advance our understanding of DDR mechanisms in cancer and foster the development of innovative treatments to enhance patient outcomes.
Dr. Jia Li
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- DNA repair and DNA damage response pathways
- cancer target therapy
- DNA replication stress response in genome stability
- oxidative stress response and redox regulation
- DNA single-strand break repair and signaling
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
