Extracellular Vesicles: Research Advances in Cancer Treatment and Diagnostics
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 50
Special Issue Editor
Interests: exosomes; tumor microenvironment; gold nanoparticles; cancer diagnostics; cancer therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Extracellular vesicles (EVs) are membrane-bound vesicles released by cells that carry RNA, proteins, and lipids. These EVs can be derived directly from the plasma membrane or be endosomal-derived vesicles ranging in size from 30 to 1000 nm. EVs are considered essential in modulating the tumor microenvironment by tumor cells and are pivotal in the preparation of the pre-metastatic niche. The intercellular communication between cancer and secondary cells through EVs allows, for example, the modulation of the immune system, giving rise to tumor-associated macrophages that promote tumor cell proliferation, vascularization of the surrounding milieu, tumor invasion of the surrounding tissues, and metastization. Since cancer-derived EVs are enriched in differentially expressed RNAs and proteins and can be found in biological fluids such as blood and urine, EVs can be used as diagnostic tools, hopefully eliminating the need for surgically obtained biopsies. For therapeutic purposes, the inhibition of cancer exosomes has been successfully attempted. The stability and biocompatibility of EVs, combined with their capacity to carry molecules with therapeutic potential and their ability to target specific cell types, have led to their increasing use as vectors for therapeutic purposes. Therefore, this Special Issue welcomes all inputs on EV research with a focus on cancer treatment and diagnostic.
Dr. Luís R. Raposo
Guest Editor
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Keywords
- extracellular vesicles
- exosomes
- cancer therapy
- diagnostics
- cellular communication
- tumor microenvironment
- EV biogenesis
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