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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Research in Metabolic Syndrome

edited by

Balazs Varga

submission deadline 30 Apr 2025 | 15 articles | Viewed by 40684 | Submission Open

Keywords: obesity; diabetes; dyslipidemia; hypertension; microcirculatory damage; ischemia-reperfusion; necro-apopto-autophagy; laboratory animals; bioactive agents

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Malignant and Potentially Malignant Disorders of the Oral Cavity: Updates from Pathogenesis to Therapy 2.0

edited by

Elena Varoni

and

Lia Rimondini

submission deadline 30 Apr 2025 | 8 articles | Viewed by 25107 | Submission Open

Keywords: oral squamous cell carcinoma; leukoplakia; erythroplakia; immunotherapy; smoking; human papilloma virus; field cancerization; oral microbiome

(This special issue belongs to the Section Cancer Biology and Oncology)

Diagnosis, Pathogenesis and Treatment of CNS Tumors

edited by

Dimitrios Kanakis

submission deadline 30 Apr 2025 | 12 articles | Viewed by 21594 | Submission Open

Keywords: CNS tumors; diagnosis; pathogenesis; treatment; prognosis; molecular markers

(This special issue belongs to the Section Molecular and Translational Medicine)

The End of the COVID-19 Pandemic—What Is Currently Known and What Could Have Been Useful Four Years Ago? (2nd Edition)

edited by

Monika Zajkowska

and

Monika Gudowska-Sawczuk

submission deadline 30 Apr 2025 | 12 articles | Viewed by 20975 | Submission Open

Keywords: COVID-19; SARS-CoV-2; pandemic; diagnosis; biomarkers; treatment; immunity; inflammation; cytokines; vaccine

(This special issue belongs to the Section Molecular and Translational Medicine)

Neurotrauma: Mechanisms, Pathways, and Emerging Therapeutic Interventions

edited by Kevin Pierre and

Brandon Lucke-Wold

submission deadline 30 Apr 2025 | 8 articles | Viewed by 20632 | Submission Open

Keywords: neurotrauma; traumatic brain injury; spinal cord injury; inflammation; oxidative stress; excitotoxicity; diagnostic biomarkers; imaging techniques; neuroprotection; neuroregeneration

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Pathomechanisms of Disturbances Underlying Chronic Disorders—2nd Edition

edited by

Dorota Formanowicz

submission deadline 30 Apr 2025 | 8 articles | Viewed by 19831 | Submission Open

Keywords: chronic disorders; atherosclerosis; inflammation; oxidative stress; lipoproteins; endothelial dysfunction; biomarkers; pathomechanisms

(This special issue belongs to the Section Immunology and Immunotherapy)

Diagnosis, Pathogenesis and Treatment of TAFRO Syndrome

edited by

Yasufumi Masaki

and Sadao Aoki

submission deadline 30 Apr 2025 | 8 articles | Viewed by 19262 | Submission Open

Keywords: hyper-inflammation syndrome; thrombocytopenia; anasarca; multicentric Castleman disease; renal dysfunction; cytokine; neoplasm; infection; collagen-vascular disorder

(This special issue belongs to the Section Immunology and Immunotherapy)

Targeting Transcription Factors and Oncogenic Proteins for Cancer Therapy (2nd Edition)

edited by

Gautam Sethi

and

Milad Ashrafizadeh

submission deadline 30 Apr 2025 | 8 articles | Viewed by 19191 | Submission Open

Keywords: cancer; transcription factors; apoptosis; oncogenes; natural agents

(This special issue belongs to the Section Cancer Biology and Oncology)

New Insights in the Pathogenesis and Treatment of Chronic Kidney Disease and Its Complications

edited by

Cristina Capusa

submission deadline 30 Apr 2025 | 1 articles | Viewed by 18594 | Submission Open

Keywords: complement-mediated glomerulopathies; cardiovascular diseases; chronic kidney disease; mechanisms of kidney fibrosis; mineral metabolism abnormalities; neurologic disorders; renal anemia; vascular calcifications; therapeutic strategies to reduce CKD progression

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Myocarditis: Molecular and Immune Mechanisms, Diagnosis and Treatment

edited by

Gaetano Thiene

submission deadline 30 Apr 2025 | 7 articles | Viewed by 16034 | Submission Open

Keywords: cardiac magnetic resonance (CMR); endomyocardial biopsy; extra corporeal membrane oxygenation (ECMO); immune system; molecular pathology; myocarditis; viruses

(This special issue belongs to the Section Immunology and Immunotherapy)

Recent Advances of Receptor Tyrosine Kinases in Solid Tumors

edited by

Parham Jabbarzadeh Kaboli

submission deadline 30 Apr 2025 | 4 articles | Viewed by 15656 | Submission Open

Keywords: targeted-therapy; solid tumors; receptor tyrosine kinase; tyrosine kinase inhibitor; FDA; c-MET; VEGFR; EGFR; ALK; growth factor

(This special issue belongs to the Section Molecular and Translational Medicine)

NASH and Hepatocellular Carcinoma (HCC)

edited by

Feng He

submission deadline 30 Apr 2025 | 5 articles | Viewed by 13546 | Submission Open

Keywords: NAFLD; NASH; HCC; obesity; inflammation; immunotherapy; stress

(This special issue belongs to the Section Cancer Biology and Oncology)

The Role of Extracellular Vesicles in Pathogenesis and Therapeutic Strategies 2.0

edited by

Allan Stensballe

submission deadline 30 Apr 2025 | 4 articles | Viewed by 11929 | Submission Open

Keywords: exosomes; inflammation; extracellular vesicles; miRNA; proteomics; signaling; mimetic vesicles

(This special issue belongs to the Section Molecular and Translational Medicine)

Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches 2.0

edited by

Byeong Hwa Jeon

and

Hee Kyoung Joo

submission deadline 30 Apr 2025 | 4 articles | Viewed by 11238 | Submission Open

Keywords: endothelial dysfunction; endothelial activation; reactive oxygen species and lipid peroxidation; atherosclerosis; adipose tissues and obesity; hypertension; hypercholesterolemia; vascular inflammation; tumor microenvironment; new biomarker or pathophysiology; novel therapeutic approach and pharmaceuticals

(This special issue belongs to the Section Immunology and Immunotherapy)

Glomerular Disease and Cystic Kidney Disease: From Pathogenesis to Novel Therapeutic Approaches

edited by Vassilis Filiopoulos and

Chrysanthi Skalioti

submission deadline 30 Apr 2025 | 5 articles | Viewed by 10621 | Submission Open

Keywords: glomerular disease; glomerulonephritis; glomerulopathy; podocytopathies; ciliopathies; cystic kidney disease; polycystic kidney disease; tolvaptan; vasopressin

(This special issue belongs to the Section Molecular and Translational Medicine)

MMPs and EMMPRIN/CD147 in Physiological and Pathological Processes 2.0

edited by

Eric Huet

submission deadline 30 Apr 2025 | 3 articles | Viewed by 8711 | Submission Open

Keywords: matrix metalloproteinases; EMMPRIN; tissue remodeling; cell interactions; physiopathology

(This special issue belongs to the Section Molecular and Translational Medicine)

Pancreatitis: Etiology, Pathology, and Treatment

edited by

Laura Gaman

, Mariana Jinga and Stoian Irina

submission deadline 30 Apr 2025 | 4 articles | Viewed by 6920 | Submission Open

Keywords: acute and chronic pancreatitis; pathophysiology; autoimmunity; novel biomarkers; innovative endoscopic; personalized treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

Oncolytic Viruses and Combinatorial Immunotherapy for Cancer

edited by

Zong Sheng Guo

and

Michael H. Lehmann

submission deadline 30 Apr 2025 | 3 articles | Viewed by 6726 | Submission Open

Keywords: oncolytic virus; antitumor immunity; cold tumor; tumor antigen; cancer vaccine; immunotherapy; combinatorial therapy; immune checkpoint blockade

(This special issue belongs to the Section Immunology and Immunotherapy)

Molecular Mechanisms and Treatments on Musculoskeletal Disorders

edited by

Wei-Bin Hsu

and

Meng-Huang Wu

submission deadline 30 Apr 2025 | 2 articles | Viewed by 6545 | Submission Open

Keywords: osteoporosis; sarcopenia; osteoblast; osteoclast; myoblast; satellite cell

(This special issue belongs to the Section Molecular and Translational Medicine)

Diabetes: Pathogenesis, Therapeutics and Outcomes

edited by Tadesse Melaku Abegaz

submission deadline 30 Apr 2025 | 4 articles | Viewed by 5779 | Submission Open

Keywords: diabetes; outcomes; treatment; pathoenesis; complications

(This special issue belongs to the Section Molecular and Translational Medicine)

Diagnosis, Pathogenesis and Treatment of Pancreatic Ductal Adenocarcinoma

edited by

Teresa Perra

and

Alberto Porcu

submission deadline 30 Apr 2025 | 4 articles | Viewed by 5387 | Submission Open

Keywords: pancreatic cancer; pancreatic ductal adenocarcinoma; treatment; management; complications; vascular reconstruction; neoadjuvant therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Advanced Biomedical Research on COVID-19 (2nd Edition)

edited by

Federica Perelli

submission deadline 30 Apr 2025 | 4 articles | Viewed by 5165 | Submission Open

Keywords: SARS-CoV-2; COVID-19; antibody; infection; immunity

(This special issue belongs to the Section Immunology and Immunotherapy)

Advances in Macrophage-Based Immunotherapy

edited by

Dolores Ortiz-Masiá

submission deadline 30 Apr 2025 | 3 articles | Viewed by 5000 | Submission Open

Keywords: macrophages; fibrosis; cancer; chronic inflammation; autophagy; apoptosis; senescence; immunotherapy

(This special issue belongs to the Section Immunology and Immunotherapy)

Molecular Processes Underlying Pathogenesis and Advanced Therapies for Genodermatosis

edited by

Natividad Cuadrado-Corrales

submission deadline 30 Apr 2025 | 3 articles | Viewed by 4955 | Submission Open

Keywords: genodermatosis; rare skin disease; molecular pathology; clinical diagnostic; gene therapy

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications, 2nd Edition

edited by

Ana Maria Dascalu

and

Dragos Serban

submission deadline 30 Apr 2025 | 2 articles | Viewed by 4782 | Submission Open

Keywords: diabetic retinopathy; diabetic foot ulcer; inflammatory biomarkers; microbiota; novel therapies

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Advances in the Treatment of Kidney and Upper Urinary Tract Cancers: Second Edition

edited by

Łukasz Zapała

submission deadline 30 Apr 2025 | 2 articles | Viewed by 4651 | Submission Open

Keywords: renal cancer; urothelial cancer; immunotherapy; systemic therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Role of Factors in Embryo Implantation and Placental Development

edited by

Micol Massimiani

and Valentina Lacconi

submission deadline 30 Apr 2025 | 3 articles | Viewed by 4242 | Submission Open

Keywords: placental development; implantation; embryo development; pregnancy disorders; endometrium; implantation failure; recurrent pregnancy loss; decidualization

(This special issue belongs to the Section Molecular and Translational Medicine)

Tumor Immune Microenvironment and Novel Strategies for Cancer Immunotherapy

edited by Sidra Islam

submission deadline 30 Apr 2025 | 3 articles | Viewed by 4177 | Submission Open

Keywords: tumor microenvironment cancer immunotherapy; immune markers; tumor infilterating immune cells; tumors

(This special issue belongs to the Section Immunology and Immunotherapy)

Biomarkers in Pain

edited by

Mats B. Eriksson

and

Anders O. Larsson

submission deadline 30 Apr 2025 | 3 articles | Viewed by 4119 | Submission Open

Keywords: analgesia; biomarker; CSF; cytokine; inflammation; neuropathy; neurotransmitter; pain; QoL; sensitization; sensory

(This special issue belongs to the Section Molecular and Translational Medicine)

Morphomolecular Characterization of Neoplastic and Pre-neoplastic Lesions in Solid Tumors

edited by Giuseppe Nicolò Fanelli and

Edoardo Francini

submission deadline 30 Apr 2025 | 3 articles | Viewed by 4087 | Submission Open

Keywords: solid cancer; molecular pathology; histopathology; diagnostic; prognostic and predictive biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

From Bench to Bedside: Advances in Non-small Cell Lung Cancer in the Era of Precision Oncology

edited by Iyare Izevbaye

submission deadline 30 Apr 2025 | 2 articles | Viewed by 3830 | Submission Open

Keywords: non-small-cell lung cancer; precision medicine; liquid biopsy; biomarkers; predictive modeling; comprehensive genomic profiling; biomarkers; immuno-oncology; lung cancer biology

(This special issue belongs to the Section Cancer Biology and Oncology)

Genetic Research on Neuropsychiatric Disorders and Complex Human Diseases

edited by Wen Zhang

submission deadline 30 Apr 2025 | 3 articles | Viewed by 3693 | Submission Open

Keywords: neuropsychiatric disorders; complex human diseases; genetic research; omics data analysis; high-throughput sequencing; machine learning; disease mechanism

(This special issue belongs to the Section Molecular and Translational Medicine)

Acute and Chronic Heart Failure: Pathophysiology and New Therapeutic Developments, 2nd Edition

edited by

Serafino Fazio

and Valentina Mercurio

submission deadline 30 Apr 2025 | 4 articles | Viewed by 3599 | Submission Open

Keywords: heart failure with reduced ejection fraction; heart failure with preserved ejection fraction; pathophysiological novelties; treatment advances; pulmonary arterial hypertension; at-home follow-up of patients with heart failure

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in the Pharmacology of Neuroendocrine Tumors

edited by

Maja Cigrovski Berković

submission deadline 30 Apr 2025 | 2 articles | Viewed by 3591 | Submission Open

Keywords: pancreatic neuroendocrine tumors; gastrointestinal endocrine tumors; treatment; systemic therapy; somatostatin; interferon-alpha; molecular-targeted agents; tumor apoptosis; symptom control

(This special issue belongs to the Section Cancer Biology and Oncology)

Interaction between Liver and Adipose Tissues

edited by Yongke Lu

submission deadline 30 Apr 2025 | 2 articles | Viewed by 3414 | Submission Open

Keywords: ethanol; bile acid; gluconeogenesis; steatosis; obesity; fatty acid oxidation; extracellular vesicles

(This special issue belongs to the Section Cell Biology and Pathology)

Molecular Research in Substance Abuse: Toxicity, Neurotoxicity and Neuropathological Findings

edited by

Angelo Montana

and

Arianna Giorgetti

submission deadline 30 Apr 2025 | 1 articles | Viewed by 3410 | Submission Open

Keywords: drug abuse; neurotoxicity; neuropathology; histopathology; immunohistochemistry; toxicology; toxicogenetics; in vitro; in vivo; and in silico models; hypoxic– ischaemic brain injury; biomarkers; behavioral addictions

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Tendinopathy and Myopathy: From Molecular Basis to Therapy

edited by

Simon Fuk-Tan Tang

and Carl Pai Chu Chen

submission deadline 30 Apr 2025 | 2 articles | Viewed by 3283 | Submission Open

Keywords: musculoskeletal disorder; tendinopathy; myopathy

(This special issue belongs to the Section Molecular and Translational Medicine)

Modulation of Anti-Tumor Immunity and Tumor Microenvironment

edited by Yu-Jen Chen

submission deadline 30 Apr 2025 | 1 articles | Viewed by 3190 | Submission Open

Keywords: anti-tumor immunity; tumor microenvironment; immunotherapy; chemotherapy; target therapy; hyperthermia; radiotherapy

(This special issue belongs to the Section Immunology and Immunotherapy)

Epigenetic Regulation in Cancer Progression

edited by

Yonghwan Shin

submission deadline 30 Apr 2025 | 2 articles | Viewed by 3180 | Submission Open

Keywords: cancer progression; epigenetic regulation; gene expression; dysregulation; therapeutic targets

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Advanced Research in Atrial Fibrillation

edited by

Wern Yew Ding

submission deadline 30 Apr 2025 | 3 articles | Viewed by 2957 | Submission Open

Keywords: atrial fibrillation; arrhythmia; electrophysiology; cardiovascular; mechanism; laboratory; experimental

(This special issue belongs to the Section Molecular and Translational Medicine)

The Development of Cancer Immunotherapy

edited by

Satoshi Wada

submission deadline 30 Apr 2025 | 3 articles | Viewed by 2855 | Submission Open

Keywords: cancer immunotherapy; immune checkpoint inhibitors; genetically modified T-cell therapy; hematological cancers; solid tumors

(This special issue belongs to the Section Cancer Biology and Oncology)

The Neuropharmacology of Cannabinoids: Developments in Medicine

edited by

Tibor Markus Brunt

submission deadline 30 Apr 2025 | 1 articles | Viewed by 2846 | Submission Open

Keywords: THC; CBD; cannabis; endocannabinoid system; therapeutic; disease; health

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Mechanisms, Implications, and Therapeutic Targets in Infectious Diseases

edited by Mihai Lazăr and Oana Săndulescu

submission deadline 30 Apr 2025 | 2 articles | Viewed by 2571 | Submission Open

Keywords: infectious diseases; virus; antibiotics; pathophysiology; molecular mechanism; therapeutic management

(This special issue belongs to the Section Immunology and Immunotherapy)

Head-and-Neck Sarcomas: Exploring Ways for Their Optimal Treatment

edited by Recine Federica,

Silvia Vanni

Alessandro De Vita

and Giacomo Miserocchi

submission deadline 30 Apr 2025 | 1 articles | Viewed by 2535 | Submission Open

Keywords: sarcomas; citogenetic features; molecular profile; novel therapeutic approaches; rare neoplasms

(This special issue belongs to the Section Cancer Biology and Oncology)

Nano-Based Drug Delivery and Drug Discovery

edited by

Xiangli Shao

submission deadline 30 Apr 2025 | 2 articles | Viewed by 2322 | Submission Open

Keywords: nanotechnology; drug discovery; drug delivery; nanocarriers; nanomaterials; drug targeting; drug release; drug therapeutic

(This special issue belongs to the Section Nanomedicine and Nanobiology)

New Insights and Latest Advances in Corneal and Ocular Surface Diseases

edited by Isabella M. Y. Cheung and Akilesh Gokul

submission deadline 30 Apr 2025 | 4 articles | Viewed by 2194 | Submission Open

Keywords: corneal disease; ocular surface disease prevention; diagnosis; management; pathobiology; epidemiology; health service delivery

(This special issue belongs to the Section Molecular and Translational Medicine)

Diagnostics and Therapy for Malignant Tumors: New Developments

edited by

Chan-Yen Kuo

submission deadline 30 Apr 2025 | 1 articles | Viewed by 2186 | Submission Open

Keywords: metabolites; immunity; microbiome; microenvironment; inflammation

(This special issue belongs to the Section Cancer Biology and Oncology)

Involvement of Free Radicals in Health and Disease

edited by

Laura Lõpez-Pingarrõn

submission deadline 30 Apr 2025 | 1 articles | Viewed by 2135 | Submission Open

Keywords: free radicals; mitochondrial ; peroxisomes; cytochrome P450

(This special issue belongs to the Section Cell Biology and Pathology)

Bioinformatics Analysis of RNA for Human Health and Disease

edited by Jihwan Ha

submission deadline 30 Apr 2025 | 2 articles | Viewed by 2024 | Submission Open

Keywords: bioinformatics; computational biology; machine learning; multi-omics data analysis; biomarker detection; biomedical AI convergence; medical and public health informatics; RNA sequencing (RNA-Seq); functional genomics; RNA-protein interactions; experimental validation of biomarkers; RNA structural biology; transcriptome-wide association studies (TWAS); gene expression profiling; RNA modifications (e.g.; m6A; pseudouridylation); in vitro and in vivo RNA functional studies; single-cell RNA analysis; RNA therapeutics development

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Diabetes: Comorbidities, Therapeutics and Insights (2nd Edition)

edited by

Tomislav Bulum

submission deadline 30 Apr 2025 | 2 articles | Viewed by 1981 | Submission Open

Keywords: diabetes; complications; diabetic retinopathy; diabetic neuropathy; diabetic nephropathy; biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

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