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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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SARS-CoV-2 Infection: Focus on Pathophysiological Characteristics, Complications and Effects of Vaccinations

edited by

Barbara Brogna

Marina Piscopo

and

Carlo Brogna

submission deadline 31 Aug 2025 | 7 articles | Viewed by 23104 | Submission Open

Keywords: SARS-CoV-2 complications; SARS-CoV2 prognostic and predictive biomarkers; long COVID-19 and autoimmune disease; COVID-19 and microbiome; artificial intelligence

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Antidepressants: 70 Years

edited by

Giovanni Lentini

and

Serge Mignani

submission deadline 31 Aug 2025 | 4 articles | Viewed by 19694 | Submission Open

Keywords: polypharmacology; multi-target drugs; emerging therapeutic targets; repurposing; unipolar depression; bipolar disorder

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

From Molecules to Medicine: Deciphering Obesity and Lipid Metabolism for Translational Insights

edited by

Abhishek Gupta

and

Sandeep Kumar

submission deadline 31 Aug 2025 | 6 articles | Viewed by 18109 | Submission Open

Keywords: obesity; insulin resistance; lipid metabolism; drug discovery

(This special issue belongs to the Section Molecular and Translational Medicine)

The Role of Chemerin in Human Disease—2nd Edition

edited by

Christa Buechler

submission deadline 31 Aug 2025 | 9 articles | Viewed by 16859 | Submission Open

Keywords: biomarker; chemotaxis; cardiovascular diseases; cancer; chemerin isoforms; CMKLR1; GPR1; CCRL2

(This special issue belongs to the Section Cell Biology and Pathology)

State-of-the-Art Molecular and Translational Medicine in Poland, 3rd Edition

edited by

Małgorzata Wrzosek

and

Arkadiusz Kocur

submission deadline 31 Aug 2025 | 6 articles | Viewed by 15462 | Submission Open

Keywords: molecular medicine; molecular mechanisms; disease pathogenesis; genetic variants; gene expression; epigenetics; metabolic disorders; cancer

(This special issue belongs to the Section Molecular and Translational Medicine)

Feature Reviews in Cardiovascular Diseases

edited by

Serafino Fazio

and

Arturo Cesaro

submission deadline 31 Aug 2025 | 6 articles | Viewed by 11892 | Submission Open

Keywords: cardiovascular diseases; heart failure; cardiac arrhythmias; metabolic syndrome; stroke; pulmonary hypertension; peripheral artery disease (PAD); acute coronary syndrome; myocarditis; pericarditis; valvulopathies

(This special issue belongs to the Section Molecular and Translational Medicine)

Cellular and Molecular Mechanisms in Gastrointestinal Tract Disease

edited by Felipe Leite De Oliveira

submission deadline 31 Aug 2025 | 6 articles | Viewed by 11408 | Submission Open

Keywords: cellular mechanisms; molecular mechanisms; diagnosis; treatment; experimental models; signaling pathways; comorbidities

(This special issue belongs to the Section Cell Biology and Pathology)

High-Risk Pregnancy, Labor and Delivery

edited by

Salvatore Andrea Mastrolia

submission deadline 31 Aug 2025 | 4 articles | Viewed by 11357 | Submission Open

Keywords: preterm labor; labor; delivery; pregnancy

(This special issue belongs to the Section Molecular and Translational Medicine)

Inflammaging and Immunosenescence: Mechanisms and Link

edited by

Chieh Yu Shen

submission deadline 31 Aug 2025 | 6 articles | Viewed by 11009 | Submission Open

Keywords: inflammaging; immunosenescence; autoimmune disease; age-related disease; aging

(This special issue belongs to the Section Immunology and Immunotherapy)

mTOR Signaling in Disease and Therapy

edited by Wenjing Yu and

Chider Chen

submission deadline 31 Aug 2025 | 5 articles | Viewed by 10966 | Submission Open

Keywords: mTOR signaling; tissue engineering; stem cell; disease; therapy; bone; craniofacial; biomedicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Compounds from Natural Products as Sources for Drug Discovery

edited by

Suzanne A. Nasser

and

Paul Horrocks

submission deadline 31 Aug 2025 | 5 articles | Viewed by 10912 | Submission Open

Keywords: natural products; drug discovery; bioactive compounds; medicinal plants; marine natural products; pharmacological screening; pharmacognosy; sustainable drug development; purification techniques; compound isolation

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Advanced Research of Stem Cells for Regenerative Medicine

edited by

Tullia Maraldi

and

Martina Gatti

submission deadline 31 Aug 2025 | 2 articles | Viewed by 9909 | Submission Open

Keywords: stem cells; regenerative therapy; degenerative diseases; aging; tissue engineering

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Cancer Biology and Experimental Anticancer Therapies (2nd Edition)

edited by

Letizia Polito

and

Ewa Gajda

submission deadline 31 Aug 2025 | 7 articles | Viewed by 9015 | Submission Open

Keywords: cancer biology; experimental anticancer therapies; immunotherapy; immunotoxins; signalling pathways; targeted therapies

(This special issue belongs to the Section Cancer Biology and Oncology)

Natural Product for the Interventions of Chronic Diseases: From Source to Therapy

edited by

Qilei Chen

submission deadline 31 Aug 2025 | 1 articles | Viewed by 7895 | Submission Open

Keywords: natural products; chronic diseases; drug discovery; pharmacodynamics; pharmacokinetics; nanotechnology

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Biomedical and Biochemical Basis of Neurodegenerative Diseases

edited by

Sarah Allegra

submission deadline 31 Aug 2025 | 4 articles | Viewed by 7873 | Submission Open

Keywords: neurodegeneration; personalized medicine; biomarkers; diagnosis; treatment

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Crohn’s Disease and Ulcerative Colitis: From Pathophysiology to Novel Therapeutic Approaches (3rd Edition)

edited by

Dingpei Long

and Junsik Sung

submission deadline 31 Aug 2025 | 8 articles | Viewed by 7770 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; chronic inflammation; pathophysiological mechanisms; therapeutic approaches; stem cell transplantation; fecal microbiota transplantation; gut microbiome; targeted therapies

(This special issue belongs to the Section Molecular and Translational Medicine)

Advancements in Artificial Intelligence (AI) for Cancer Genomics and Genetics

edited by

Roberto Piergentili

submission deadline 31 Aug 2025 | 4 articles | Viewed by 6668 | Submission Open

Keywords: artificial intelligence; cancer; genetics; epigenetics; genomics; epigenomics; gene-environment interaction; cancer diagnosis and prognosis; personalized medicine; drug discovery

(This special issue belongs to the Section Cancer Biology and Oncology)

Neuroendocrine Neoplasia and Endocrine Tumors: Pathogenic Features, Prognostic Markers and New Therapeutic Approaches

edited by

Mara Carsote

submission deadline 31 Aug 2025 | 4 articles | Viewed by 6212 | Submission Open

Keywords: neuroendocrine tumors; endocrine tumors; somatostatin analogues; carcinoid syndrome; PRRT; mTOR inhibitor; lymph node; neuroendocrine marker; hormone; ki67

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Digestive Disorders: Translation and Bridging the Gap Between Research, Diagnosis, and Treatment

edited by Goran Hauser and Goran Poropat

submission deadline 31 Aug 2025 | 5 articles | Viewed by 6074 | Submission Open

Keywords: acute pancreatis; clinical nutrition; metabolic disorders; NAFLD; obesity; DGBA; gut microbiota

(This special issue belongs to the Section Molecular and Translational Medicine)

Mitochondrial Dysfunction and Oxidative Stress

edited by

Susana Cardoso

submission deadline 31 Aug 2025 | 2 articles | Viewed by 6074 | Submission Open

Keywords: mitochondria; oxidative stress; brain metabolism; neurodevelopmental diseases; neuropsychiatric diseases; neurodegenerative diseases; mitochondrial medicine; translational medicine

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Mechanisms and Novel Therapeutic Approaches for Neurodegenerative Diseases (2nd Edition)

edited by

Fernando Cardona

submission deadline 31 Aug 2025 | 3 articles | Viewed by 5783 | Submission Open

Keywords: neurodegenerative diseases; cellular mechanisms; molecular mechanisms; neurodegeneration models; protein misfolding; protein aggregation; neuronal death; molecular therapy; cellular therapy; therapeutics; medical chemistry; drug screening

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Role of Bone Marrow Niche in Haematological Cancers

edited by

Jehan J. El-Jawhari

submission deadline 31 Aug 2025 | 3 articles | Viewed by 5165 | Submission Open

Keywords: blood cancers; bone marrow; microenvironment; immune stromal interactions; mesenchymal stem cells

(This special issue belongs to the Section Cancer Biology and Oncology)

Adiposity, Inflammation, and Metabolic Regulation: Molecular Mechanisms and Therapeutic Strategies

edited by

Qianfen Wan

submission deadline 31 Aug 2025 | 3 articles | Viewed by 4496 | Submission Open

Keywords: adipose tissue; inflammation; obesity and its metabolic complications; obesity pathogenesis

(This special issue belongs to the Section Molecular and Translational Medicine)

Connective Tissue Disorders: Pathogenetic, Diagnostic and Therapeutic Perspectives

edited by

Katarzyna Winsz-Szczotka

submission deadline 31 Aug 2025 | 3 articles | Viewed by 4321 | Submission Open

Keywords: connective tissue disorders; pathophysiological mechanisms; inflammation; autoimmunity; extracellular matrix; fibrosis; biomarkers; treatment; therapeutic targets

(This special issue belongs to the Section Molecular and Translational Medicine)

Bioactive Peptides and Derivatives as Therapeutic Agents: Potential Applications in Disease Treatment

edited by

Toshihiro Kita

submission deadline 31 Aug 2025 | 1 articles | Viewed by 4239 | Submission Open

Keywords: bioactive peptide; peptide modification; application; cardiovascular disease; inflammatory disease; digestive disease; neurological disease; drug development

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

MicroRNAs as Mediators of Tumor Cell State Transitions, Receptor Remodeling, Drug Resistance, and Systemic Metastasis

edited by

Vinitha Richard

and Michael J. Kerin

submission deadline 31 Aug 2025 | 2 articles | Viewed by 3721 | Submission Open

Keywords: solid epithelial tumors; cancer stem cells; microRNAs; epigenetics; cell state transitions; chemoresistance; immunosuppression; tumor microenvironment; metastasis

(This special issue belongs to the Section Cancer Biology and Oncology)

Platelets in Health and Disease: From Molecular Mechanisms to Therapeutic Potential

edited by Henry Nording

submission deadline 31 Aug 2025 | 2 articles | Viewed by 3651 | Submission Open

Keywords: platelet biology; vascular immunity; atherosclerosis; therapeutic targets; biomarkers

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in Polycystic Ovary Syndrome Research: From Molecular Mechanisms to Therapeutic Strategies—2nd Edition

edited by

Ebrahim Asadi

submission deadline 31 Aug 2025 | 3 articles | Viewed by 3499 | Submission Open

Keywords: female infertility; endocrine disorder; metabolic disorder; polycystic ovary syndrome; polycystic ovariany morphology; hyperandrogenism; menstrual irregularity; theraputicsTherapeutics; oxidative stress; antioxidant

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Pathogenesis, Diagnosis and Treatment of Infectious Diseases

edited by

Laura Franza

submission deadline 31 Aug 2025 | 6 articles | Viewed by 3190 | Submission Open

Keywords: infection; infectious diseases; vaccination; antibiotics; antibiotic resistance; novel therapies; novel diagnosis; inflammaging; immunosenescence

(This special issue belongs to the Section Molecular and Translational Medicine)

Meningioma: Novel Diagnostic and Therapeutic Approaches

edited by Carlen A. Yuen

submission deadline 31 Aug 2025 | 1 articles | Viewed by 3117 | Submission Open

Keywords: meningioma; atypical; anaplastic; PET DOTATATE; octreotide; Lutetium-177; targeted therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Advanced Research on Fibromyalgia (3rd Edition)

edited by

Elena Lucarini

submission deadline 31 Aug 2025 | 3 articles | Viewed by 3032 | Submission Open

Keywords: fibromyalgia; chronic fatigue syndrome; myofascial pain syndrome; diagnostic biomarkers; biomarkers for predicting treatment response; disability; rehabilitation; chronic pain; mutations and polymorphisms of genes related to fibromyalgia; epigenetics

(This special issue belongs to the Section Molecular and Translational Medicine)

Recent Advances in the Discovery of Novel Drugs on Natural Molecules, Second Edition

edited by

Laura Quintieri

Leonardo Caputo

and

Orazio Nicolotti

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2778 | Submission Open

Keywords: natural compounds; bioactive peptides; peptidomimetics; microbial metabolites; polyphenols; genome mining; molecular modeling; therapeutic uses

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Lipids and Lipid Metabolism in Cardiovascular Health and Disease

edited by Fei Luo

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2508 | Submission Open

Keywords: lipids; lipoproteins; lipid metabolism; cardiovascular health and disease; atherosclerotic cardiovascular disease; lipid-lowering therapy; triglyceride-lowering therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Pediatric Ocular Pathology and Treatment

edited by Hyun-jin Shin

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2362 | Submission Open

Keywords: pediatric ophthalmology; eye diseases; genetics; medical; diagnostic techniques; ophthalmological; therapeutics

(This special issue belongs to the Section Cell Biology and Pathology)

Advanced Research on Skeletal Muscle Metabolism

edited by Lorenzo Sanesi

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2318 | Submission Open

Keywords: energy metabolism; mebabolic signaling pathways; homeostasis; myokines; aging; atrophy; muscle metabolism

(This special issue belongs to the Section Molecular and Translational Medicine)

Advancements in Induced Pluripotent Stem Cells

edited by

M. Esther Gallardo

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2269 | Submission Open

Keywords: induced pluripotent stem cells; organoids; tissue engineering; biomaterials; reprogramming; iPSC-based cell modelling; cell therapy; microfluidics; drug discovery

(This special issue belongs to the Section Gene and Cell Therapy)

Advancements in Brain Diagnosis and Treatment: From Insights to Innovations

edited by Irene Chaves-Coira and

Brandon Lucke-Wold

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2231 | Submission Open

Keywords: brain diagnosis and treatment; underlying mechanisms; individualized treatment

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Biotechnology in the Treatment and Management of Hearing Loss

edited by

Alessandro Castiglione

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2207 | Submission Open

Keywords: hearing loss; gene therapy; regenerative medicine; cochlear implants; nanotechnology stem cell therapy; CRISPR-Cas9; auditory prosthetics; artificial intelligence; auditory regeneration

(This special issue belongs to the Section Biomedical Engineering and Materials)

Microbial Infections and Sepsis: Pathophysiological Mechanisms and Therapeutic Approaches

edited by

Nirupam Biswas

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1972 | Submission Open

Keywords: sepsis; cytokines; inflammation; bacteria; stem cell; molecular biology; flow cytometry; multiplex; MALDI-TOF-MS; RT-PCR

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Mechanisms and Therapeutic Approaches for Hepatocellular Carcinoma

edited by Lanqi Gong,

Xinyuan Guan

and Yu Zhang

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1970 | Submission Open

Keywords: hepatocellular carcinoma; HCC diagnosis and prognosis; HCC mechanisms; therapeutic resistance; immunotherapy; targeted therapy; personalized medicine; drug development; clinical trials; translational studies

(This special issue belongs to the Section Cancer Biology and Oncology)

Emerging Trends in the Study of Inherited Metabolic Disorders

edited by Sudeep Gautam

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1849 | Submission Open

Keywords: inherited metabolic disorders; glycogen storage diseases; genetically modified mouse models; liver and kidney disease; hepatocellular carcinoma; autophagy; diabetes mellitus; patient-derived organoids; gene therapy

(This special issue belongs to the Section Gene and Cell Therapy)

Recent Advances in Biomedical Engineering for the Aging Population

edited by

Weichih Lien

and Wen-Fong Wang

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1623 | Submission Open

Keywords: biomedical engineering; geriatric engineering; senescence; regenerative medicine; rehabilitation

(This special issue belongs to the Section Biomedical Engineering and Materials)

Gliomas: Signaling Pathways, Molecular Mechanisms and Novel Therapies (2nd Edition)

edited by

Hung-Pei Tsai

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1405 | Submission Open

Keywords: glioma; molecular pathology; blood– brain barrier; immunotherapy; microenvironment; nanomedicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Brain Imaging and Cognitive Deficits in Psychiatric Disorders, 2nd Edition

edited by

Wenbin Guo

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1203 | Submission Open

Keywords: cognitive deficits; psychiatric disorders; schizophrenia; brain imaging

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Biomedicine in Dental and Oral Rehabilitation

edited by

Sanda Mihaela Popescu

and

Mihaela Ionescu

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1191 | Submission Open

Keywords: diagnosis; treatment; oral rehabilitation; dental and oral disease; biomedicine; biomaterial; regeneration; functional; esthetics

(This special issue belongs to the Section Biomedical Engineering and Materials)

Progress in Immunopharmacy

edited by

Po-Jen Chen

and Shun-Hua Chen

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1164 | Submission Open

Keywords: immunopharmacy; immunopharmacology; immunomodulation; pharmacological intervention; immunotherapy; drug– immune system interaction; vaccine development; personalized pharmacotherapy

(This special issue belongs to the Section Immunology and Immunotherapy)

New Perspectives in the Treatment of Head and Neck Vascular Malformations

edited by Paolo Gennaro

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1121 | Submission Open

Keywords: vascular anomalies; vascular malformations; AVMs; venous malformations; electrosclerotherapy

(This special issue belongs to the Section Molecular and Translational Medicine)

The Role of Cytokines in Health and Disease: 3rd Edition

edited by

Monika Zajkowska

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1103 | Submission Open

Keywords: cytokine; chemokine; neurodegenerative disease; cancer; inflammatory mediator; diagnosis; biomarker

(This special issue belongs to the Section Cell Biology and Pathology)

The Role of Immune Response in the Protection Against SARS-CoV-2 Infection

edited by

Cinzia Giagulli

submission deadline 31 Aug 2025 | 1 articles | Viewed by 956 | Submission Open

Keywords: SARS-CoV-2; COVID-19; immune response; innate immune system; adaptative response; vaccines

(This special issue belongs to the Section Immunology and Immunotherapy)

Osteoarthritis: Molecular Pathways and Novel Therapeutic Strategies—2nd Edition

edited by

Antonia Patruno

Teresa Paolucci

Mirko Pesce

and Andrea Pantalone

submission deadline 31 Aug 2025 | 1 articles | Viewed by 927 | Submission Open

Keywords: osteoarthritis; cartilage; pain; orthopedics; rehabilitation

(This special issue belongs to the Section Molecular and Translational Medicine)

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