Antimicrobial Stewardship in Solid Organ Transplantation: Optimizing Management of Infections Caused by Resistant Organisms

Dear Colleagues,

This Special Issue focuses on the critical topic of antimicrobial stewardship in the context of solid organ transplantation. It provides a comprehensive overview of the challenges and emerging strategies for managing infections in the era of multi-drug resistance in transplant recipients.

The Special Issue begins by highlighting the unique vulnerabilities of solid organ transplant patients to infectious complications, related to their underlying medical conditions, their immunosuppressed state and the use of antimicrobials during various stages of the transplantation process. It underscores the growing threat of antimicrobial resistance, which can compromise the effectiveness of traditional treatment approaches and lead to worse outcomes for these high-risk patients. This Special Issue delves into the complex interplay between transplant immunology, infectious disease dynamics and antimicrobial resistance.

Recognizing the importance of early and appropriate antimicrobial therapy, the Special Issue emphasizes the role of antimicrobial stewardship programs in solid organ transplantation. It examines evidence-based strategies for antimicrobial selection, dosing optimization and de-escalation, aimed at minimizing the development and spread of resistance while ensuring the effective management of infections.

The Special Issue also highlights the significance of diagnostic advancements in guiding antimicrobial decision-making for transplant recipients. It explores the potential of rapid diagnostic tests, molecular methods and predictive algorithms in identifying the causative pathogens and their resistance profiles, enabling tailored and targeted antimicrobial therapy.

Additionally, the Special Issue delves into the emerging therapeutic options for resistant infections in solid organ transplant patients. It discusses the use of novel antimicrobial agents, combination therapies and adjunctive interventions, such as immunomodulatory approaches, to combat multidrug-resistant infections.

Overall, this Special Issue serves as a valuable resource for transplant clinicians, infectious disease specialists and healthcare policymakers, providing a deeper understanding of the challenges and emerging solutions in the management of antimicrobial resistance in solid organ transplant recipients.

Dr. Abhay Dhand
Guest Editor

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• transplant
• antimicrobial stewardship
• quality
• outcomes
• infectious diseases
• antimicrobial resistance