Neuroscience Through Electrophysiology: Current Trends and Future Directions
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 124
Special Issue Editor
Interests: neuroscience; aging; neuroimaging; neurodevelopmental disorders; electrophysiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Electrophysiology has long served as a cornerstone of neuroscience, offering unparalleled insights into the dynamic electrical activity that underpins brain function. By measuring voltage changes and ionic currents across neuronal membranes, electrophysiological techniques—from single-channel recordings to large-scale electroencephalography (EEG)—have decoded the mechanisms of action potentials, synaptic transmission, and network oscillations. Pioneering work, such as the Hodgkin–Huxley model derived from voltage-clamp studies, laid the foundation for understanding neural excitability, while intracellular and extracellular recordings have mapped the connectivity and plasticity of neural circuits. Clinically, electrophysiology has been indispensable in diagnosing disorders like epilepsy and Parkinson’s disease, linking aberrant electrical patterns to pathological states.
This Special Issue highlights the latest advancements in electrophysiological methods and their applications in modern neuroscience. The collection covers a wide range of topics, including innovations in in vitro patch-clamp whole-cell recording, high-density multi-electrode arrays, the optogenetic modulation of neural circuits, and the integration of electrophysiology with neuroimaging and computational modeling. These approaches provide deeper insights into neural circuit function, synaptic plasticity, and the pathophysiology of neurodevelopmental and neurodegenerative disorders.
Looking ahead, the combination of electrophysiology with multimodal imaging, genomics, and bioelectronic interfaces holds the potential for transformative breakthroughs. Furthermore, the Issue explores the future trajectory of electrophysiology, focusing on emerging technologies such as brain–machine interfaces, artificial intelligence-driven data analysis, and non-invasive electrophysiological techniques for clinical applications. This discussion highlights electrophysiology’s translational potential, which includes enhancing brain–machine interfaces and personalizing treatments for neuropsychiatric conditions.
Collectively, this Special Issue aims to foster interdisciplinary collaborations and drive new discoveries in neuroscience. We invite researchers to contribute their findings, helping to shape the future of electrophysiology and its role in understanding and treating neurological and psychiatric disorders.
Dr. Xiaokuang Ma
Guest Editor
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Keywords
- electrophysiology
- neural circuit
- synaptic plasticity
- neuronal membrane
- patch-clamp
- action potential
- ion channels
- neurodevelopmental disorders
- neurodegenerative disorders
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