Feature Papers in Biomedical Engineering in Human Health
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Prof. Dr. Robert Passier
Prof. Dr. Robert Passier
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Department of Applied Stem Cell Technologies, University of Twente, 7500 AE Enschede, The Netherlands
Interests: cardiac myocytes; pluripotent stem cells; stem cells; in vitro techniques; human embryonic stem cells; genes
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Dear Colleagues,
This Topical Collection, “Feature Papers in Biomedical Engineering in Human Health”, will comprise important contributions by scholars in the field of biomedical engineering and the Editorial Board members of Biomedicines. Their broad expertise will result in a comprehensive array of the latest findings in this field; thus, we encourage submissions of high-quality research papers or review articles. Potential topics might include, but are by no means limited to:
- Tissue engineering;
- Cell engineering;
- Biomaterials;
- Regenerative medicine;
- Stem cells;
- Disease modelling;
- Molecular mechanisms;
- Genetic engineering;
- Protein engineering;
- Antibody engineering;
- Artificial intelligence in healthcare;
- Bioinformatics of diseases;
- 3D bioprinting;
- 3D cell culture systems;
- Organoids;
- Micro-/nano-systems and microfluidic chips;
- Organ-on-chip;
- Biomedical sensors;
- Biomedical signal and image processing.
Prof. Dr. Robert Passier
Collection Editor
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Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
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Published Papers (1 paper)
2022
Open AccessReview
Aptamers Targeting Cardiac Biomarkers as an Analytical Tool for the Diagnostics of Cardiovascular Diseases: A Review
by
Natalia Komarova, Olga Panova, Alexey Titov and Alexander Kuznetsov
Cited by 26 | Viewed by 6819
Abstract
The detection of cardiac biomarkers is used for diagnostics, prognostics, and the risk assessment of cardiovascular diseases. The analysis of cardiac biomarkers is routinely performed with high-sensitivity immunological assays. Aptamers offer an attractive alternative to antibodies for analytical applications but, to date, are
[...] Read more.
The detection of cardiac biomarkers is used for diagnostics, prognostics, and the risk assessment of cardiovascular diseases. The analysis of cardiac biomarkers is routinely performed with high-sensitivity immunological assays. Aptamers offer an attractive alternative to antibodies for analytical applications but, to date, are not widely practically implemented in diagnostics and medicinal research. This review summarizes the information on the most common cardiac biomarkers and the current state of aptamer research regarding these biomarkers. Aptamers as an analytical tool are well established for troponin I, troponin T, myoglobin, and C-reactive protein. For the rest of the considered cardiac biomarkers, the isolation of novel aptamers or more detailed characterization of the known aptamers are required. More attention should be addressed to the development of dual-aptamer sandwich detection assays and to the studies of aptamer sensing in alternative biological fluids. The universalization of aptamer-based biomarker detection platforms and the integration of aptamer-based sensing to clinical studies are demanded for the practical implementation of aptamers to routine diagnostics. Nevertheless, the wide usage of aptamers for the diagnostics of cardiovascular diseases is promising for the future, with respect to both point-of-care and laboratory testing.
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