Autophagy in Health and Disease
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 214
Special Issue Editor
Interests: innate immunity; molecular and cell biology; stem cell technology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autophagy is a highly evolutionarily conserved cellular process in eukaryotic organisms. In this process, the bilayer membrane structure is formed to encase a fraction of cytoplasm and small organelles, which are transported to lysosomes for digestion. According to the pathway of substrate entry into lysosomes, autophagy can be classified into three types: macroautophagy, microautophagy and chaperone-mediate autophagy. Under normal conditions, cells maintain a low level of autophagy, which can not only remove aggregated proteins, but also eliminate damaged organelles. Small molecules such as amino acids produced by lysosomal degradation can be recycled by cells. Under adverse conditions such as hypoxia or nutrient deprivation, cells will further activate autophagy to degrade non-essential organelles to maintain cell survival. Mitochondrial autophagy, also called mitophagy, is a notable cellular process which selectively removes damaged mitochondria. Recent studies have shown that mitophagy is involved in aging as well as many disease processes, including heart disease, Parkinson’s disease and Leigh syndrome.
This Special Issue on “Autophagy in Health and Disease” aims to provide up-to-date insight into the remarkable complexity of autophagy, and on its dysregulation in the context of many different human diseases, including (but not limited to) heart disease, neurodegenerative diseases, aging, cancer and mitochondrial diseases.
We look forward to receiving your contributions.
Dr. Mingchong Yang
Guest Editor
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Keywords
- autophagy
- mitophagy
- heart disease
- neurodegenerative diseases
- aging
- cancer
- mitochondrial diseases
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