Nutrient Sensing, Redox Homeostasis and Metabolic Diseases: Molecular Insight
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 463
Special Issue Editor
Interests: cancer metabolism; miRNA; metabolic disorder; cardiovascular biology; endothelial biology; exosome biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic diseases are one of the most prevalent causes of death worldwide. With the prevalence of sedentary lifestyles and physical inactivity, cases of metabolic disorders such as obesity, diabetes, and other associated disorders such as atherosclerosis, neurodegenerative disorders, cancer, and liver diseases such as NAFLD and NASH are significantly increasing in high numbers. Cardiometabolic disease alone is a leading cause of death, surpassing even cancer-related deaths. Managing metabolic diseases is becoming a daunting task with limited treatment options available.
Excess energy intake results in various complications, including the generation of ROS. Excess ROS generated as a byproduct of enhanced metabolism and inflammation could damage cells or organelles. The dysfunction of the metabolic system generally occurs due to the disturbance in energy balance, nutrient sensing, and altered redox homeostasis, leading to the development of various disorders, including diabetes, obesity, and cancer. An intervention involving diet manipulation or caloric restriction have shown some promising outcomes, including a delay in age-related disease. Pathways that mainly involve energy sensing and homeostasis are mTOR, sirtuins (SIRT1), AMPK, and insulin/insulin growth factor-1 (IGF-1). Alteration in these pathways may lead to altered nutrient sensing and redox homeostasis and thus the development of metabolic disorders. Understanding the mechanism behind how these pathways are altered during the progression or development of metabolic diseases could be beneficial for managing these diseases. For this Special Issue, we invite articles related to the areas of cellular or systemic metabolism, nutrient sensing, redox homeostasis, drugs mimicking dietary intervention, or caloric restrictions such as metformin and resveratrol in metabolic diseases including obesity, diabetes, cardiovascular, liver disorders, and cancers.
Dr. Bal Krishna Chaube
Guest Editor
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Keywords
- metabolic disease
- obesity
- cardiovascular disorders
- liver disorders
- cancer
- metabolism
- mitochondria
- AMPK
- SIRT1
- mTOR
- IGF-1
- insulin resistance
- ROS
- redox homeostasis
- calorie restriction
- metformin
- resveratrol
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