Amyloid-β Dynamics and Neurodegeneration: Mechanistic Insights and Therapeutic Strategies
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 82
Special Issue Editor
2. Postdoctoral Research Fellow, Department of Neurosciences, Institute for Cell Engineering, School of Medicine, Johns Hopkins University, 733 North Broadway, MRB 720, Baltimore, MD 21205, USA
Interests: neurodegenerative diseases; including Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA)
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases, including Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA), are characterized by impaired amyloid-β clearance, leading to amyloid-β accumulation. The goal of this Special Issue is to look at the molecular mechanisms that explain the dynamics of amyloid-β and how they relate to neurodegeneration (AD, CAA). We are currently seeking the submission of papers (original research, review articles, mini review articles, and opinions) that investigate multiple mechanisms in the brain and periphery that are involved in the metabolism and clearance of amyloid-β. Interest areas include the blood–brain barrier dynamics, interstitial fluid flow, glial and neuronal cell involvement, enzymatic and non-enzymatic clearance mechanisms, and the interconnections of peripheral organs. Furthermore, there is tremendous potential for research on new targets for preventing amyloid-β deposition and innovative therapeutic approaches to improve amyloid-β clearance. The goal of this Special Issue is to address research gaps, improve understanding of AD pathophysiology, and provide effective strategies for treatment.
Dr. Rahat Ullah
Guest Editor
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Keywords
- Alzheimer’s disease (AD)
- amyloid-β clearance
- brain and periphery
- cerebral amyloid angiopathy (CAA)
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