Platelets in Health and Disease: From Molecular Mechanisms to Therapeutic Potential
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 38
Special Issue Editor
2. DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, 23562 Lübeck, Germany
Interests: immunology; cardiology; vascular biology
Special Issue Information
Dear Colleagues,
Platelets are remarkably versatile cells, widely recognized for their central role in primary hemostasis. Their significance as key targets for pharmacological therapy in both primary and secondary prevention, as well as after vascular interventions involving the implantation of exogenous materials into the bloodstream, is well established. Moreover, the involvement of platelets in atherosclerosis is undisputed.
Recently, platelets have also been implicated in various tissue remodeling processes, such as apoptosis, immune patrolling, and adaptive immunity. They play a critical role in the immediate response to vascular injury by promoting vascular inflammation and immunomodulation. These discoveries have led to a broader understanding of platelets as immune cells.
Platelets continue to captivate both clinicians and basic scientists as new interactions between platelets, their precursor cells (megakaryocytes), and novel immune cell populations are uncovered. Emerging roles of platelets in disease mechanisms are being identified, and they are increasingly recognized as valuable targets for therapeutic interventions and as potential biomarkers.
Contributions to this Special Issue, "Platelets in Health and Disease: From Molecular Mechanisms to Therapeutic Potential", should focus on recent advancements that reinforce the concept of platelets as crucial mediators of vascular immunity, integral components of the immune system, promising therapeutic targets, or biomarkers, particularly in relation to their lipidome, transcriptome, or proteome.
Dr. Henry Nording
Guest Editor
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Keywords
- platelet biology
- vascular immunity
- atherosclerosis
- therapeutic targets
- biomarkers
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